Gene/Proteome Database (LMPD)

LMPD ID
LMP005338
Gene ID
6296
Species
Homo sapiens (Human)
Gene Name
acyl-CoA synthetase medium-chain family member 3
Gene Symbol
ACSM3
Synonyms
SA; SAH
Alternate Names
acyl-coenzyme A synthetase ACSM3, mitochondrial; protein SA homolog; butyrate--CoA ligase 3; butyryl-coenzyme A synthetase 3; SA hypertension-associated homolog; middle-chain acyl-CoA synthetase 3; SA (rat hypertension-associated) homolog
Chromosome
16
Map Location
16p13.11
EC Number
6.2.1.2

Proteins

acyl-coenzyme A synthetase ACSM3, mitochondrial isoform 1
Refseq ID NP_005613
Protein GI 42544132
UniProt ID Q53FZ2
mRNA ID NM_005622
Length 586
RefSeq Status VALIDATED
MLARVTRKMLRHAKCFQRLAIFGSVRALHKDNRTATPQNFSNYESMKQDFKLGIPEYFNFAKDVLDQWTDKEKAGKKPSNPAFWWINRNGEEMRWSFEELGSLSRKFANILSEACSLQRGDRVILILPRVPEWWLANVACLRTGTVLIPGTTQLTQKDILYRLQSSKANCIITNDVLAPAVDAVASKCENLHSKLIVSENSREGWGNLKELMKHASDSHTCVKTKHNEIMAIFFTSGTSGYPKMTAHTHSSFGLGLSVNGRFWLDLTPSDVMWNTSDTGWAKSAWSSVFSPWIQGACVFTHHLPRFEPTSILQTLSKYPITVFCSAPTVYRMLVQNDITSYKFKSLKHCVSAGEPITPDVTEKWRNKTGLDIYEGYGQTETVLICGNFKGMKIKPGSMGKPSPAFDVKIVDVNGNVLPPGQEGDIGIQVLPNRPFGLFTHYVDNPSKTASTLRGNFYITGDRGYMDKDGYFWFVARADDVILSSGYRIGPFEVENALNEHPSVAESAVVSSPDPIRGEVVKAFVVLNPDYKSHDQEQLIKEIQEHVKKTTAPYKYPRKVEFIQELPKTISGKTKRNELRKKEWKTI
acyl-coenzyme A synthetase ACSM3, mitochondrial isoform 2
Refseq ID NP_973729
Protein GI 42544134
UniProt ID Q53FZ2
mRNA ID NM_202000
Length 438
RefSeq Status VALIDATED
MLARVTRKMLRHAKCFQRLAIFGSVRALHKDNRTATPQNFSNYESMKQDFKLGIPEYFNFAKDVLDQWTDKEKAGKKPSNPAFWWINRNGEEMRWSFEELGSLSRKFANILSEACSLQRGDRVILILPRVPEWWLANVACLRTGTVLIPGTTQLTQKDILYRLQSSKANCIITNDVLAPAVDAVASKCENLHSKLIVSENSREGWGNLKELMKHASDSHTCVKTKHNEIMAIFFTSGTSGYPKMTAHTHSSFGLGLSVNGRFWLDLTPSDVMWNTSDTGWAKSAWSSVFSPWIQGACVFTHHLPRFEPTSILQTLSKYPITVFCSAPTVYRMLVQNDITSYKFKSLKHCVSAGEPITPDVTEKWRNKTGLDIYEGYGQTETVLICGNFKGMKIKPGSMGKPSPAFDVKVCTSPSRRMFNNPICTLPTYRLPPYKLSLL
transit_peptide: 1..27 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (Potential); propagated from UniProtKB/Swiss-Prot (Q53FZ2.2) calculated_mol_wt: 3161 peptide sequence: MLARVTRKMLRHAKCFQRLAIFGSVRA mat_peptide: 28..586 product: Acyl-coenzyme A synthetase ACSM3, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q53FZ2.2) calculated_mol_wt: 63010 peptide sequence: LHKDNRTATPQNFSNYESMKQDFKLGIPEYFNFAKDVLDQWTDKEKAGKKPSNPAFWWINRNGEEMRWSFEELGSLSRKFANILSEACSLQRGDRVILILPRVPEWWLANVACLRTGTVLIPGTTQLTQKDILYRLQSSKANCIITNDVLAPAVDAVASKCENLHSKLIVSENSREGWGNLKELMKHASDSHTCVKTKHNEIMAIFFTSGTSGYPKMTAHTHSSFGLGLSVNGRFWLDLTPSDVMWNTSDTGWAKSAWSSVFSPWIQGACVFTHHLPRFEPTSILQTLSKYPITVFCSAPTVYRMLVQNDITSYKFKSLKHCVSAGEPITPDVTEKWRNKTGLDIYEGYGQTETVLICGNFKGMKIKPGSMGKPSPAFDVKIVDVNGNVLPPGQEGDIGIQVLPNRPFGLFTHYVDNPSKTASTLRGNFYITGDRGYMDKDGYFWFVARADDVILSSGYRIGPFEVENALNEHPSVAESAVVSSPDPIRGEVVKAFVVLNPDYKSHDQEQLIKEIQEHVKKTTAPYKYPRKVEFIQELPKTISGKTKRNELRKKEWKTI transit_peptide: 1..27 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (Potential); propagated from UniProtKB/Swiss-Prot (Q53FZ2.2) calculated_mol_wt: 3161 peptide sequence: MLARVTRKMLRHAKCFQRLAIFGSVRA

Gene Information

Entrez Gene ID
6296
Gene Name
acyl-CoA synthetase medium-chain family member 3
Gene Symbol
ACSM3
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005759 IEA:Ensembl C mitochondrial matrix
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0047760 IEA:UniProtKB-EC F butyrate-CoA ligase activity
GO:0015645 IEA:Ensembl F fatty acid ligase activity
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0042632 NAS:BHF-UCL P cholesterol homeostasis
GO:0006633 IEA:Ensembl P fatty acid biosynthetic process
GO:0008217 NAS:UniProtKB P regulation of blood pressure

KEGG Pathway Links

KEGG Pathway ID Description
hsa00650 Butanoate metabolism
hsa01100 Metabolic pathways

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-7049 eicosapentaenoate biosynthesis II (metazoa)
PWY-6000 gamma-linolenate biosynthesis II (animals)

Domain Information

InterPro Annotations

Accession Description
IPR025110 AMP-binding enzyme C-terminal domain
IPR020845 AMP-binding, conserved site
IPR000873 AMP-dependent synthetase/ligase

UniProt Annotations

Entry Information

Gene Name
acyl-CoA synthetase medium-chain family member 3
Protein Entry
ACSM3_HUMAN
UniProt ID
Q53FZ2
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q53FZ2-1; Sequence=Displayed; Name=2; IsoId=Q53FZ2-2; Sequence=VSP_028395, VSP_028396;
Catalytic Activity ATP + a carboxylate + CoA = AMP + diphosphate + an acyl-CoA.
Caution It is uncertain whether Met-1 or Met-9 is the initiator.
Cofactor Name=Mg(2+); Xref=ChEBI
Function Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4- unsaturated acids (in vitro) (By similarity).
Sequence Caution Sequence=AAC31667.1; Type=Erroneous initiation; Evidence= ; Sequence=BAA03853.1; Type=Erroneous initiation; Evidence= ; Sequence=CAA56369.1; Type=Erroneous initiation; Evidence= ;
Similarity Belongs to the ATP-dependent AMP-binding enzyme family.
Subcellular Location Mitochondrion matrix .

Identical and Related Proteins

Unique RefSeq proteins for LMP005338 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
42544132 RefSeq NP_005613 586 acyl-coenzyme A synthetase ACSM3, mitochondrial isoform 1
42544134 RefSeq NP_973729 438 acyl-coenzyme A synthetase ACSM3, mitochondrial isoform 2

Identical Sequences to LMP005338 proteins

Reference Database Accession Length Protein Name
GI:42544134 GenBank AAH02790.3 438 Acyl-CoA synthetase medium-chain family member 3 [Homo sapiens]
GI:42544134 GenBank EAW66834.1 438 acyl-CoA synthetase medium-chain family member 3, isoform CRA_a [Homo sapiens]
GI:42544132 GenBank EAW66835.1 586 acyl-CoA synthetase medium-chain family member 3, isoform CRA_b [Homo sapiens]
GI:42544134 GenBank ABM83905.1 438 acyl-CoA synthetase medium-chain family member 3 [synthetic construct]
GI:42544134 GenBank ABM87226.1 438 acyl-CoA synthetase medium-chain family member 3, partial [synthetic construct]
GI:42544134 GenBank ABW03856.1 438 acyl-CoA synthetase medium-chain family member 3 [synthetic construct]
GI:42544132 GenBank AFO05675.1 586 Sequence 313 from patent US 8216786
GI:42544134 GenBank AFO05676.1 438 Sequence 314 from patent US 8216786
GI:42544132 SwissProt Q53FZ2.2 586 RecName: Full=Acyl-coenzyme A synthetase ACSM3, mitochondrial; AltName: Full=Acyl-CoA synthetase medium-chain family member 3; AltName: Full=Butyrate--CoA ligase 3; AltName: Full=Butyryl-coenzyme A synthetase 3; AltName: Full=Middle-chain acyl-CoA synthetase 3; AltName: Full=Protein SA homolog; Flags: Precursor [Homo sapiens]

Related Sequences to LMP005338 proteins

Reference Database Accession Length Protein Name
GI:42544132 DBBJ BAD96859.1 586 SA hypertension-associated homolog isoform 1 variant, partial [Homo sapiens]
GI:42544132 DBBJ BAF83011.1 586 unnamed protein product [Homo sapiens]
GI:42544134 EMBL CAA56369.1 430 SA [Homo sapiens]
GI:42544132 GenBank AAC31667.1 578 SA gene [Homo sapiens]
GI:42544134 GenBank EAW66835.1 586 acyl-CoA synthetase medium-chain family member 3, isoform CRA_b [Homo sapiens]
GI:42544134 GenBank AFO05675.1 586 Sequence 313 from patent US 8216786
GI:42544134 GenBank AIC59246.1 430 ACSM3, partial [synthetic construct]
GI:42544134 RefSeq NP_005613.2 586 acyl-coenzyme A synthetase ACSM3, mitochondrial isoform 1 [Homo sapiens]
GI:42544132 RefSeq XP_001158747.1 586 PREDICTED: acyl-coenzyme A synthetase ACSM3, mitochondrial isoform X2 [Pan troglodytes]
GI:42544132 RefSeq XP_003812118.1 586 PREDICTED: acyl-coenzyme A synthetase ACSM3, mitochondrial isoform X1 [Pan paniscus]
GI:42544132 RefSeq XP_004057357.1 586 PREDICTED: acyl-coenzyme A synthetase ACSM3, mitochondrial [Gorilla gorilla gorilla]
GI:42544134 SwissProt Q53FZ2.2 586 RecName: Full=Acyl-coenzyme A synthetase ACSM3, mitochondrial; AltName: Full=Acyl-CoA synthetase medium-chain family member 3; AltName: Full=Butyrate--CoA ligase 3; AltName: Full=Butyryl-coenzyme A synthetase 3; AltName: Full=Middle-chain acyl-CoA synthetase 3; AltName: Full=Protein SA homolog; Flags: Precursor [Homo sapiens]