Gene/Proteome Database (LMPD)

LMPD ID
LMP004975
Gene ID
157506
Species
Homo sapiens (Human)
Gene Name
retinol dehydrogenase 10 (all-trans)
Gene Symbol
RDH10
Synonyms
SDR16C4
Alternate Names
retinol dehydrogenase 10; short chain dehydrogenase/reductase family 16C, member 4
Chromosome
8
Map Location
8q21.11
EC Number
1.1.1.300
Summary
This gene encodes a retinol dehydrogenase, which converts all-trans-retinol to all-trans-retinal, with preference for NADP as a cofactor. Studies in mice suggest that this protein is essential for synthesis of embryonic retinoic acid and is required for limb, craniofacial, and organ development. [provided by RefSeq, Dec 2011]
Orthologs
View orthologs and multiple alignments for RDH10

Proteins

retinol dehydrogenase 10
Refseq ID NP_742034
Protein GI 25282469
UniProt ID Q8IZV5
mRNA ID NM_172037
Length 341
RefSeq Status REVIEWED
MNIVVEFFVVTFKVLWAFVLAAARWLVRPKEKSVAGQVCLITGAGSGLGRLFALEFARRRALLVLWDINTQSNEETAGMVRHIYRDLEAADAAALQAGNGEEEILPHCNLQVFTYTCDVGKRENVYLTAERVRKEVGEVSVLVNNAGVVSGHHLLECPDELIERTMMVNCHAHFWTTKAFLPTMLEINHGHIVTVASSLGLFSTAGVEDYCASKFGVVGFHESLSHELKAAEKDGIKTTLVCPYLVDTGMFRGCRIRKEIEPFLPPLKPDYCVKQAMKAILTDQPMICTPRLMYIVTFMKSILPFEAVVCMYRFLGADKCMYPFIAQRKQATNNNEAKNGI

Gene Information

Entrez Gene ID
157506
Gene Name
retinol dehydrogenase 10 (all-trans)
Gene Symbol
RDH10
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0044297 IEA:Ensembl C cell body
GO:0005737 IDA:UniProtKB C cytoplasm
GO:0005789 TAS:Reactome C endoplasmic reticulum membrane
GO:0016021 IDA:UniProtKB C integral component of membrane
GO:0052650 IEA:UniProtKB-EC F NADP-retinol dehydrogenase activity
GO:0004745 IDA:UniProtKB F retinol dehydrogenase activity
GO:0060449 IEA:Ensembl P bud elongation involved in lung branching
GO:0043583 IEA:Ensembl P ear development
GO:0031076 IEA:Ensembl P embryonic camera-type eye development
GO:0035115 IEA:Ensembl P embryonic forelimb morphogenesis
GO:0048703 IEA:Ensembl P embryonic viscerocranium morphogenesis
GO:0008406 IEA:Ensembl P gonad development
GO:0001701 IEA:Ensembl P in utero embryonic development
GO:0001656 IEA:Ensembl P metanephros development
GO:0014032 IEA:Ensembl P neural crest cell development
GO:0043584 IEA:Ensembl P nose development
GO:0007603 TAS:Reactome P phototransduction, visible light
GO:0060431 IEA:Ensembl P primary lung bud formation
GO:0042574 IDA:UniProtKB P retinal metabolic process
GO:0002138 IEA:Ensembl P retinoic acid biosynthetic process
GO:0001523 TAS:Reactome P retinoid metabolic process
GO:0042572 IDA:UniProtKB P retinol metabolic process
GO:0007601 IDA:MGI P visual perception

KEGG Pathway Links

KEGG Pathway ID Description
hsa00830 Retinol metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_160156 The canonical retinoid cycle in rods (twilight vision)

Domain Information

InterPro Annotations

Accession Description
IPR002347 Glucose/ribitol dehydrogenase
IPR016040 NAD(P)-binding domain
IPR002198 Short-chain dehydrogenase/reductase SDR
IPR020904 Short-chain dehydrogenase/reductase, conserved site

UniProt Annotations

Entry Information

Gene Name
retinol dehydrogenase 10 (all-trans)
Protein Entry
RDH10_HUMAN
UniProt ID
Q8IZV5
Species
Human

Comments

Comment Type Description
Catalytic Activity All-trans-retinol + NADP(+) = all-trans- retinal + NADPH.
Function Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinol to all-trans-retinal. Has no detectable activity towards 11-cis-retinol, 9-cis-retinol and 13-cis-retinol.
Pathway Cofactor metabolism; retinol metabolism.
Similarity Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Subcellular Location Microsome membrane ; Single- pass membrane protein . Endoplasmic reticulum membrane ; Single-pass membrane protein .
Tissue Specificity Detected in retina, kidney, liver, small intestine, placenta, lung, heart and skeletal muscle.

Identical and Related Proteins

Unique RefSeq proteins for LMP004975 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
25282469 RefSeq NP_742034 341 retinol dehydrogenase 10

Identical Sequences to LMP004975 proteins

Reference Database Accession Length Protein Name
GI:25282469 RefSeq XP_006054253.1 341 PREDICTED: retinol dehydrogenase 10 [Bubalus bubalis]
GI:25282469 RefSeq XP_007185109.1 341 PREDICTED: retinol dehydrogenase 10 [Balaenoptera acutorostrata scammoni]
GI:25282469 RefSeq XP_007453773.1 341 PREDICTED: retinol dehydrogenase 10 [Lipotes vexillifer]
GI:25282469 RefSeq XP_007538926.1 341 PREDICTED: retinol dehydrogenase 10 [Erinaceus europaeus]
GI:25282469 RefSeq XP_007999064.1 341 PREDICTED: retinol dehydrogenase 10 [Chlorocebus sabaeus]
GI:25282469 RefSeq XP_010361808.1 341 PREDICTED: retinol dehydrogenase 10 [Rhinopithecus roxellana]

Related Sequences to LMP004975 proteins

Reference Database Accession Length Protein Name
GI:25282469 GenBank ELR47777.1 342 Retinol dehydrogenase 10, partial [Bos mutus]
GI:25282469 RefSeq XP_004372587.1 341 PREDICTED: retinol dehydrogenase 10 [Trichechus manatus latirostris]
GI:25282469 RefSeq XP_004653342.1 341 PREDICTED: retinol dehydrogenase 10 [Jaculus jaculus]
GI:25282469 RefSeq XP_006880526.1 341 PREDICTED: retinol dehydrogenase 10 [Elephantulus edwardii]
GI:25282469 RefSeq XP_007954956.1 341 PREDICTED: retinol dehydrogenase 10 [Orycteropus afer afer]
GI:25282469 RefSeq XP_008070842.1 341 PREDICTED: retinol dehydrogenase 10 [Tarsius syrichta]