Gene/Proteome Database (LMPD)

LMPD ID
LMP004919
Gene ID
338596
Species
Homo sapiens (Human)
Gene Name
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6
Gene Symbol
ST8SIA6
Synonyms
SIA8F; SIAT8F; ST8SIA-VI
Alternate Names
alpha-2,8-sialyltransferase 8F; SIAT8-F; ST8SiaVI; sialytransferase St8Sia VI; sialyltransferase St8Sia VI; alpha-2,8-sialyltransferase 8F variant 2; alpha-2,8-sialyltransferase 8F variant 3; sialyltransferase 8F (alpha-2, 8-sialyltransferase)
Chromosome
10
Map Location
10p12.33
EC Number
2.4.99.-
Summary
Sialic acid is a key determinate of oligosaccharide structures involved in cell-cell communication, cell-substrate interaction, adhesion, and protein targeting. ST8SIA6 belongs to a family of sialyltransferases (EC 2.4.99.8) that synthesize sialylglycoconjugates (Takashima et al., 2002 [PubMed 11980897]).[supplied by OMIM, Mar 2008]
Orthologs
View orthologs and multiple alignments for ST8SIA6

Proteins

alpha-2,8-sialyltransferase 8F precursor
Refseq ID NP_001004470
Protein GI 54234057
UniProt ID P61647
mRNA ID NM_001004470
Length 398
RefSeq Status VALIDATED
MRPGGALLALLASLLLLLLLRLLWCPADAPGRARILVEESREATHGTPAALRTLRSPATAVPRATNSTYLNEKSLQLTEKCKNLQYGIESFSNKTKGYSENDYLQIITDIQSCPWKRQAEEYANFRAKLASCCDAVQNFVVSQNNTPVGTNMSYEVESKKEIPIKKNIFHMFPVSQPFVDYPYNQCAVVGNGGILNKSLCGTEIDKSDFVFRCNLPPTTGDVSKDVGSKTNLVTINPSIITLKYGNLKEKKALFLEDIATYGDAFFLLPAFSFRANTGTSFKVYYTLEESKARQKVLFFHPKYLKDLALFWRTKGVTAYRLSTGLMITSVAVELCKNVKLYGFWPFSKTVEDIPVSHHYYDNKLPKHGFHQMPKEYSQILQLHMKGILKLQFSKCEVA
sig_peptide: 1..29 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 3088 peptide sequence: MRPGGALLALLASLLLLLLLRLLWCPADA

Gene Information

Entrez Gene ID
338596
Gene Name
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6
Gene Symbol
ST8SIA6
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0000139 TAS:Reactome C Golgi membrane
GO:0030173 IEA:InterPro C integral component of Golgi membrane
GO:0008373 ISS:BHF-UCL F sialyltransferase activity
GO:0016051 ISS:BHF-UCL P carbohydrate biosynthetic process
GO:0044267 TAS:Reactome P cellular protein metabolic process
GO:0001574 ISS:BHF-UCL P ganglioside biosynthetic process
GO:0009247 ISS:BHF-UCL P glycolipid biosynthetic process
GO:0009100 ISS:BHF-UCL P glycoprotein metabolic process
GO:0009311 ISS:BHF-UCL P oligosaccharide metabolic process
GO:0043687 TAS:Reactome P post-translational protein modification
GO:0018279 TAS:Reactome P protein N-linked glycosylation via asparagine
GO:0006493 ISS:BHF-UCL P protein O-linked glycosylation
GO:0097503 ISS:GOC P sialylation

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_25085 N-Glycan antennae elongation
REACT_25208 N-glycan antennae elongation in the medial/trans-Golgi
REACT_200874 Sialic acid metabolism
REACT_22387 Synthesis of substrates in N-glycan biosythesis

Domain Information

InterPro Annotations

Accession Description
IPR001675 Glycosyl transferase, family 29
IPR012163 Sialyltransferase

UniProt Annotations

Entry Information

Gene Name
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6
Protein Entry
SIA8F_HUMAN
UniProt ID
P61647
Species
Human

Comments

Comment Type Description
Function Prefers O-glycans to N-glycans or glycolipids as acceptor substrates. The minimal acceptor substrate is the NeuAc- alpha-2,3(6)-Gal sequence at the non-reducing end of their carbohydrate groups (By similarity).
Pathway Protein modification; protein glycosylation.
Similarity Belongs to the glycosyltransferase 29 family.
Subcellular Location Golgi apparatus membrane ; Single-pass type II membrane protein .
Web Resource Name=Functional Glycomics Gateway - GTase; Note=ST8Sia VI; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_641";
Web Resource Name=GGDB; Note=GlycoGene database; URL="http://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=ST8SIA6";

Identical and Related Proteins

Unique RefSeq proteins for LMP004919 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
54234057 RefSeq NP_001004470 398 alpha-2,8-sialyltransferase 8F precursor

Identical Sequences to LMP004919 proteins

Reference Database Accession Length Protein Name
GI:54234057 EMBL CAS91700.1 398 unnamed protein product [Homo sapiens]
GI:54234057 EMBL CCF76970.1 398 unnamed protein product [Homo sapiens]
GI:54234057 GenBank ACA06074.1 398 alpha-2,8-sialyltransferase 8F variant 2 [Homo sapiens]
GI:54234057 GenBank ACA06075.1 398 alpha-2,8-sialyltransferase 8F variant 3 [Homo sapiens]
GI:54234057 GenBank AAI37104.1 398 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 [Homo sapiens]
GI:54234057 GenBank AAI37103.1 398 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 [Homo sapiens]

Related Sequences to LMP004919 proteins

Reference Database Accession Length Protein Name
GI:54234057 DBBJ BAE94653.1 398 alpha-2,8-sialyltransferase [Homo sapiens]
GI:54234057 EMBL CAG26901.1 398 alpha-2,8-sialyltransferase 8F [Pan troglodytes]
GI:54234057 RefSeq NP_001032373.1 398 alpha-2,8-sialyltransferase 8F precursor [Pan troglodytes]
GI:54234057 RefSeq XP_002820610.1 398 PREDICTED: alpha-2,8-sialyltransferase 8F [Pongo abelii]
GI:54234057 RefSeq XP_008000590.1 398 PREDICTED: alpha-2,8-sialyltransferase 8F [Chlorocebus sabaeus]
GI:54234057 SwissProt P61648.1 398 RecName: Full=Alpha-2,8-sialyltransferase 8F; AltName: Full=Sialyltransferase 8F; Short=SIAT8-F; AltName: Full=Sialyltransferase St8Sia VI; Short=ST8SiaVI [Pan troglodytes]