Gene/Proteome Database (LMPD)

LMPD ID
LMP004863
Gene ID
71883
Species
Mus musculus (Mouse)
Gene Name
coenzyme Q2 homolog, prenyltransferase (yeast)
Gene Symbol
Coq2
Synonyms
2310002F18Rik
Alternate Names
4-hydroxybenzoate polyprenyltransferase, mitochondrial; PHB:polyprenyltransferase; para-hydroxybenzoate--polyprenyltransferase, mitochondrial
Chromosome
5
Map Location
5|5 E3
EC Number
2.5.1.39

Proteins

4-hydroxybenzoate polyprenyltransferase, mitochondrial precursor
Refseq ID NP_082254
Protein GI 167004227
UniProt ID Q66JT7
mRNA ID NM_027978
Length 374
RefSeq Status VALIDATED
MLRWGGAGLARGLRAVRSAWLRGPRGLPLALVRSAGVPGARDRRAPAPGTQRGRALSLSAAAVVNSAPRPLQPYLRLMRLDKPIGTWLLYLPCTWSIGLAADPGCFPDWYMLSLFGTGAILMRGAGCTINDMWDRDFDKKVTRTANRPIAAGDISTFQSFVFLGGQLTLALGVLLCLNYYSIAMGAASLLLVVTYPLVKRITFWPQLALGLTFNWGALLGWSAVKGSCDPAVCLPLYFSGVMWTLIYDTIYAHQDKKDDALIGLKSTALLFQENTRQWLSGFGVAMVAALSLAGANNGQTVPYYAAVAAVGAHLAHQIYTVDIHRAEDCWDKFTSNRTVGMLLFLGIVLGNLCKEKTEEAKDAEAVRVGSEQTS
transit_peptide: 1..34 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (Potential); propagated from UniProtKB/Swiss-Prot (Q66JT7.2) calculated_mol_wt: 3671 peptide sequence: MLRWGGAGLARGLRAVRSAWLRGPRGLPLALVRS mat_peptide: 35..374 product: 4-hydroxybenzoate polyprenyltransferase, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q66JT7.2) calculated_mol_wt: 36851 peptide sequence: AGVPGARDRRAPAPGTQRGRALSLSAAAVVNSAPRPLQPYLRLMRLDKPIGTWLLYLPCTWSIGLAADPGCFPDWYMLSLFGTGAILMRGAGCTINDMWDRDFDKKVTRTANRPIAAGDISTFQSFVFLGGQLTLALGVLLCLNYYSIAMGAASLLLVVTYPLVKRITFWPQLALGLTFNWGALLGWSAVKGSCDPAVCLPLYFSGVMWTLIYDTIYAHQDKKDDALIGLKSTALLFQENTRQWLSGFGVAMVAALSLAGANNGQTVPYYAAVAAVGAHLAHQIYTVDIHRAEDCWDKFTSNRTVGMLLFLGIVLGNLCKEKTEEAKDAEAVRVGSEQTS

Gene Information

Entrez Gene ID
71883
Gene Name
coenzyme Q2 homolog, prenyltransferase (yeast)
Gene Symbol
Coq2
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005739 IDA:MGI C mitochondrion
GO:0002083 IEA:UniProtKB-EC F 4-hydroxybenzoate decaprenyltransferase activity
GO:0047293 IEA:UniProtKB-EC F 4-hydroxybenzoate nonaprenyltransferase activity
GO:0006071 IEA:Ensembl P glycerol metabolic process
GO:0008299 IEA:UniProtKB-KW P isoprenoid biosynthetic process
GO:0006744 IEA:UniProtKB-UniPathway P ubiquinone biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu00130 Ubiquinone and other terpenoid-quinone biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
5893941 Mitochondrial protein import
5894069 Ubiquinol biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR006370 4-hydroxybenzoate polyprenyl transferase
IPR000537 UbiA prenyltransferase family

UniProt Annotations

Entry Information

Gene Name
coenzyme Q2 homolog, prenyltransferase (yeast)
Protein Entry
COQ2_MOUSE
UniProt ID
Q66JT7
Species
Mouse

Comments

Comment Type Description
Catalytic Activity A polyprenyl diphosphate + 4-hydroxybenzoate = diphosphate + a 4-hydroxy-3-polyprenylbenzoate.
Function Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB (By similarity). {ECO:0000250}.
Pathway Cofactor biosynthesis; ubiquinone biosynthesis.
Sequence Caution Sequence=BAB26064.1; Type=Erroneous termination; Positions=303; Note=Translated as Tyr.; Evidence={ECO:0000305};
Similarity Belongs to the UbiA prenyltransferase family. {ECO:0000305}.
Subcellular Location Mitochondrion membrane {ECO:0000250}; Multi- pass membrane protein {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP004863 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
167004227 RefSeq NP_082254 374 4-hydroxybenzoate polyprenyltransferase, mitochondrial precursor

Identical Sequences to LMP004863 proteins

Reference Database Accession Length Protein Name
GI:167004227 SwissProt Q66JT7.2 374 RecName: Full=4-hydroxybenzoate polyprenyltransferase, mitochondrial; AltName: Full=Para-hydroxybenzoate--polyprenyltransferase; Short=PHB:polyprenyltransferase; Flags: Precursor [Mus musculus]

Related Sequences to LMP004863 proteins

Reference Database Accession Length Protein Name
GI:167004227 GenBank AGO28198.1 371 p-hydroxybenzoate polyprenyl transferase [Bos taurus]
GI:167004227 RefSeq XP_002717029.1 371 PREDICTED: 4-hydroxybenzoate polyprenyltransferase, mitochondrial [Oryctolagus cuniculus]
GI:167004227 RefSeq XP_004430961.1 371 PREDICTED: 4-hydroxybenzoate polyprenyltransferase, mitochondrial [Ceratotherium simum simum]
GI:167004227 RefSeq XP_005359617.1 367 PREDICTED: 4-hydroxybenzoate polyprenyltransferase, mitochondrial [Microtus ochrogaster]
GI:167004227 RefSeq XP_005339369.1 371 PREDICTED: 4-hydroxybenzoate polyprenyltransferase, mitochondrial [Ictidomys tridecemlineatus]
GI:167004227 RefSeq XP_008845072.1 371 PREDICTED: 4-hydroxybenzoate polyprenyltransferase, mitochondrial [Nannospalax galili]