Gene/Proteome Database (LMPD)

LMPD ID
LMP004803
Gene ID
105501
Species
Mus musculus (Mouse)
Gene Name
abhydrolase domain containing 4
Gene Symbol
Abhd4
Synonyms
1110035H23Rik; AI429574; Abh4
Chromosome
14
Map Location
14 C2|14

Proteins

abhydrolase domain-containing protein 4 isoform 1
Refseq ID NP_598837
Protein GI 326937491
UniProt ID Q3U7M5
mRNA ID NM_134076
Length 355
RefSeq Status VALIDATED
MGWLSSTRQGLFTMADDLEQQPQGWLSSWLPTWRPTSMSQLKNVEARILQCLQNKFLARYVSLPNQNKIWTVTVSPEQKDRTPLVMVHGFGGGVGLWILNMDSLSARRTLHTFDLLGFGRSSRPTFPRDPEGAEDEFVASIETWRETMGIPTMILLGHSLGGFLATSYSIKYPERVKHLILVDPWGFPLRPTDPSEIRAPPTWVKAVASVLGRSNPLAVLRVAGPWGPGLVQRFRPDFKRKFADFFEDDTISEYIYHCNAQNPSGETAFKAMMESFGWARRPMLERIHLIRKDVPITMIYGANTWIDTSTGKKVKMQRPDSYVRDMEIEGASHHVYADQPHIFNAVVEEICNSVD
abhydrolase domain-containing protein 4 isoform 2
Refseq ID NP_001192110
Protein GI 326937494
UniProt ID Q8C0M2
mRNA ID NM_001205181
Length 318
RefSeq Status VALIDATED
MSQLKNVEARILQCLQNKFLARYVSLPNQNKIWTVTVSPEQKDRTPLVMVHGFGGGVGLWILNMDSLSARRTLHTFDLLGFGRSSRPTFPRDPEGAEDEFVASIETWRETMGIPTMILLGHSLGGFLATSYSIKYPERVKHLILVDPWGFPLRPTDPSEIRAPPTWVKAVASVLGRSNPLAVLRVAGPWGPGLVQRFRPDFKRKFADFFEDDTISEYIYHCNAQNPSGETAFKAMMESFGWARRPMLERIHLIRKDVPITMIYGANTWIDTSTGKKVKMQRPDSYVRDMEIEGASHHVYADQPHIFNAVVEEICNSVD

Gene Information

Entrez Gene ID
105501
Gene Name
abhydrolase domain containing 4
Gene Symbol
Abhd4
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016787 IEA:UniProtKB-KW F hydrolase activity
GO:0016042 IEA:UniProtKB-KW P lipid catabolic process

Domain Information

InterPro Annotations

Accession Description
IPR029058 Alpha/Beta hydrolase fold
IPR000073 Alpha/beta hydrolase fold-1

UniProt Annotations

Entry Information

Gene Name
abhydrolase domain containing 4
Protein Entry
ABHD4_MOUSE
UniProt ID
Q8C0M2
Species
Mouse

Comments

Comment Type Description
Caution Thr-291 is present instead of the conserved His which is expected to be an active site residue. {ECO:0000305}.
Function Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lysophosphatidylethanolamine and lysophosphatidylserine. {ECO:0000269|PubMed:16818490}.
Similarity Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily. {ECO:0000305}.
Tissue Specificity Highest levels in the CNS and in testis, intermediate levels in liver and kidney. Hardly detectable in heart. {ECO:0000269|PubMed:16818490}.

Identical and Related Proteins

Unique RefSeq proteins for LMP004803 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
326937491 RefSeq NP_598837 355 abhydrolase domain-containing protein 4 isoform 1
326937494 RefSeq NP_001192110 318 abhydrolase domain-containing protein 4 isoform 2

Identical Sequences to LMP004803 proteins

Reference Database Accession Length Protein Name
GI:326937494 DBBJ BAC26863.1 318 unnamed protein product [Mus musculus]
GI:326937494 DBBJ BAE36606.1 318 unnamed protein product [Mus musculus]
GI:326937491 DBBJ BAE31344.1 355 unnamed protein product [Mus musculus]
GI:326937494 RefSeq XP_006518430.1 318 PREDICTED: abhydrolase domain-containing protein 4 isoform X1 [Mus musculus]

Related Sequences to LMP004803 proteins

Reference Database Accession Length Protein Name
GI:326937494 DBBJ BAC33711.1 342 unnamed protein product [Mus musculus]
GI:326937494 DBBJ BAE31344.1 355 unnamed protein product [Mus musculus]
GI:326937494 EMBL CBN68793.1 342 unnamed protein product [Mus musculus]
GI:326937494 EMBL CBN69749.1 342 unnamed protein product [Mus musculus]
GI:326937494 GenBank AAH17532.1 342 Abhydrolase domain containing 4 [Mus musculus]
GI:326937491 GenBank EDM14149.1 355 abhydrolase domain containing 4 (predicted) [Rattus norvegicus]
GI:326937491 GenBank ERE89349.1 355 abhydrolase domain-containing protein 4 [Cricetulus griseus]
GI:326937491 RefSeq NP_001102336.1 355 abhydrolase domain-containing protein 4 [Rattus norvegicus]
GI:326937491 RefSeq XP_003506166.1 355 PREDICTED: abhydrolase domain-containing protein 4 isoform X1 [Cricetulus griseus]
GI:326937491 RefSeq XP_005370553.1 355 PREDICTED: abhydrolase domain-containing protein 4 [Microtus ochrogaster]
GI:326937491 RefSeq XP_007624697.1 355 PREDICTED: abhydrolase domain-containing protein 4 isoform X1 [Cricetulus griseus]
GI:326937494 SwissProt Q8VD66.1 342 RecName: Full=Abhydrolase domain-containing protein 4; AltName: Full=Alpha/beta-hydrolase 4; AltName: Full=Lyso-N-acylphosphatidylethanolamine lipase [Mus musculus]