Gene/Proteome Database (LMPD)
Proteins
| hormone-sensitive lipase isoform 1 | |
|---|---|
| Refseq ID | NP_034849 |
| Protein GI | 87239970 |
| UniProt ID | P54310 |
| mRNA ID | NM_010719 |
| Length | 802 |
| RefSeq Status | VALIDATED |
| MEPAVESAPVGAQASKQGKEGSKNRSRRRWRKGKIKASAFSHSMDLRTMTQSLVTLAEDNMAFFSSQGPGETARRLSNVFAGVREQALGLEPTLGQLLGVAHHFDLDTETPANGYRSLVHTARCCLAHLLHKSRYVASNRKSIFFRASHNLAELEAYLAALTQLRAMAYYAQRLLTINRPGVLFFEGDEGLTADFLQEYVTLHKGCFYGRCLGFQFTPAIRPFLQTLSIGLVSFGEHYKRNETGLSVTASSLFTGGRFAIDPELRGAEFERIIQNLDVHFWKAFWNITEIEVLSSLANMASTTVRVSRLLSLPPEAFEMPLTSDPRLTVTISPPLAHTGPAPVLARLISYDLREGQDSKVLNSLAKSEGPRLELRPRPHQAPRSRALVVHIHGGGFVAQTSKSHEPYLKNWAQELGVPIFSIDYSLAPEAPFPRALEECFFAYCWAVKHCDLLGSTGERICLAGDSAGGNLCITVSLRAAAYGVRVPDGIMAAYPVTTLQSSASPSRLLSLMDPLLPLSVLSKCVSAYSGTEAEDHFDSDQKALGVMGLVQRDTSLFLRDLRLGASSWLNSFLELSGRKPQKTTSPTAESVRPTESMRRSVSEAALAQPEGLLGTDTLKKLTIKDLSNSEPSDSPEMSQSMETLGPSTPSDVNFFLRPGNSQEEAEAKDEVRPMDGVPRVRAAFPEGFHPRRSSQGVLHMPLYTSPIVKNPFMSPLLAPDSMLKTLPPVHLVACALDPMLDDSVMFARRLRDLGQPVTLKVVEDLPHGFLSLAALCRETRQATEFCVQRIRLILTPPAAPLN | |
| hormone-sensitive lipase isoform 2 | |
|---|---|
| Refseq ID | NP_001034596 |
| Protein GI | 87239972 |
| UniProt ID | P54310 |
| mRNA ID | NM_001039507 |
| Length | 759 |
| RefSeq Status | VALIDATED |
| MDLRTMTQSLVTLAEDNMAFFSSQGPGETARRLSNVFAGVREQALGLEPTLGQLLGVAHHFDLDTETPANGYRSLVHTARCCLAHLLHKSRYVASNRKSIFFRASHNLAELEAYLAALTQLRAMAYYAQRLLTINRPGVLFFEGDEGLTADFLQEYVTLHKGCFYGRCLGFQFTPAIRPFLQTLSIGLVSFGEHYKRNETGLSVTASSLFTGGRFAIDPELRGAEFERIIQNLDVHFWKAFWNITEIEVLSSLANMASTTVRVSRLLSLPPEAFEMPLTSDPRLTVTISPPLAHTGPAPVLARLISYDLREGQDSKVLNSLAKSEGPRLELRPRPHQAPRSRALVVHIHGGGFVAQTSKSHEPYLKNWAQELGVPIFSIDYSLAPEAPFPRALEECFFAYCWAVKHCDLLGSTGERICLAGDSAGGNLCITVSLRAAAYGVRVPDGIMAAYPVTTLQSSASPSRLLSLMDPLLPLSVLSKCVSAYSGTEAEDHFDSDQKALGVMGLVQRDTSLFLRDLRLGASSWLNSFLELSGRKPQKTTSPTAESVRPTESMRRSVSEAALAQPEGLLGTDTLKKLTIKDLSNSEPSDSPEMSQSMETLGPSTPSDVNFFLRPGNSQEEAEAKDEVRPMDGVPRVRAAFPEGFHPRRSSQGVLHMPLYTSPIVKNPFMSPLLAPDSMLKTLPPVHLVACALDPMLDDSVMFARRLRDLGQPVTLKVVEDLPHGFLSLAALCRETRQATEFCVQRIRLILTPPAAPLN | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005901 | ISS:UniProtKB | C | caveola |
| GO:0005737 | ISS:UniProtKB | C | cytoplasm |
| GO:0005829 | IDA:MGI | C | cytosol |
| GO:0005811 | IDA:UniProtKB | C | lipid particle |
| GO:0005739 | ISS:UniProtKB | C | mitochondrion |
| GO:0005634 | ISS:UniProtKB | C | nucleus |
| GO:0033878 | IEA:UniProtKB-EC | F | hormone-sensitive lipase activity |
| GO:0019901 | IPI:UniProtKB | F | protein kinase binding |
| GO:0042134 | ISS:UniProtKB | F | rRNA primary transcript binding |
| GO:0004806 | IMP:MGI | F | triglyceride lipase activity |
| GO:0008203 | IEA:UniProtKB-KW | P | cholesterol metabolic process |
| GO:0046340 | IDA:MGI | P | diacylglycerol catabolic process |
| GO:0016042 | IDA:UniProtKB | P | lipid catabolic process |
| GO:0042758 | IDA:MGI | P | long-chain fatty acid catabolic process |
| GO:0006363 | ISS:UniProtKB | P | termination of RNA polymerase I transcription |
| GO:0006361 | ISS:UniProtKB | P | transcription initiation from RNA polymerase I promoter |
| GO:0019433 | IDA:MGI | P | triglyceride catabolic process |
KEGG Pathway Links
Domain Information
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P54310-1; Sequence=Displayed; Name=2; IsoId=P54310-2; Sequence=VSP_053335; |
| Catalytic Activity | Diacylglycerol + H(2)O = monoacylglycerol + a carboxylate. |
| Catalytic Activity | Monoacylglycerol + H(2)O = glycerol + a carboxylate. |
| Catalytic Activity | Triacylglycerol + H(2)O = diacylglycerol + a carboxylate. |
| Enzyme Regulation | Rapidly activated by cAMP-dependent phosphorylation under the influence of catecholamines. Dephosphorylation and inactivation are controlled by insulin (By similarity). Interacts with PLIN5. {ECO:0000250}. |
| Function | In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production. {ECO:0000269|PubMed:23291629}. |
| Pathway | Glycerolipid metabolism; triacylglycerol degradation. |
| Ptm | Phosphorylation by AMPK may block translocation to lipid droplets. {ECO:0000269|PubMed:15878856, ECO:0000269|PubMed:19921680}. |
| Similarity | Belongs to the 'GDXG' lipolytic enzyme family. {ECO:0000305}. |
| Subcellular Location | Cell membrane {ECO:0000250}. Membrane, caveola {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Note=Found in the high-density caveolae. Translocates to the cytoplasm from the caveolae upon insulin stimulation. {ECO:0000250}. |
| Subunit | Interacts with PTRF in the adipocyte cytoplasm. {ECO:0000250}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP004801 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 87239970 | RefSeq | NP_034849 | 802 | hormone-sensitive lipase isoform 1 |
| 87239972 | RefSeq | NP_001034596 | 759 | hormone-sensitive lipase isoform 2 |
Identical Sequences to LMP004801 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:87239970 | DBBJ | BAC26716.1 | 802 | unnamed protein product [Mus musculus] |
| GI:87239972 | GenBank | AAC53069.1 | 759 | hormone-sensitive lipase [Mus musculus] |
| GI:87239972 | GenBank | AAH21642.1 | 759 | Lipase, hormone sensitive [Mus musculus] |
| GI:87239972 | GenBank | EDL24272.1 | 759 | lipase, hormone sensitive [Mus musculus] |
| GI:87239972 | RefSeq | XP_006539634.1 | 759 | PREDICTED: hormone-sensitive lipase isoform X2 [Mus musculus] |
| GI:87239972 | RefSeq | XP_006539635.1 | 759 | PREDICTED: hormone-sensitive lipase isoform X3 [Mus musculus] |
| GI:87239972 | SwissProt | P54310.2 | 759 | RecName: Full=Hormone-sensitive lipase; Short=HSL [Mus musculus] |
Related Sequences to LMP004801 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:87239972 | DBBJ | BAC26716.1 | 802 | unnamed protein product [Mus musculus] |
| GI:87239972 | DBBJ | BAE41414.1 | 759 | unnamed protein product [Mus musculus] |
| GI:87239972 | GenBank | AAC52163.1 | 759 | hormone-sensitive lipase [Mus musculus domesticus] |
| GI:87239970 | GenBank | AAH21642.1 | 759 | Lipase, hormone sensitive [Mus musculus] |
| GI:87239970 | GenBank | EDL24272.1 | 759 | lipase, hormone sensitive [Mus musculus] |
| GI:87239972 | RefSeq | NP_034849.2 | 802 | hormone-sensitive lipase isoform 1 [Mus musculus] |
| GI:87239970 | RefSeq | XP_006228453.1 | 811 | PREDICTED: hormone-sensitive lipase isoform X1 [Rattus norvegicus] |
| GI:87239972 | RefSeq | XP_006539633.1 | 1072 | PREDICTED: hormone-sensitive lipase isoform X1 [Mus musculus] |
| GI:87239970 | RefSeq | XP_006539633.1 | 1072 | PREDICTED: hormone-sensitive lipase isoform X1 [Mus musculus] |
| GI:87239970 | RefSeq | XP_006539634.1 | 759 | PREDICTED: hormone-sensitive lipase isoform X2 [Mus musculus] |
| GI:87239970 | RefSeq | XP_006539635.1 | 759 | PREDICTED: hormone-sensitive lipase isoform X3 [Mus musculus] |
| GI:87239972 | SwissProt | P15304.3 | 1068 | RecName: Full=Hormone-sensitive lipase; Short=HSL [Rattus norvegicus] |