Gene/Proteome Database (LMPD)

LMPD ID
LMP004744
Gene ID
84243
Species
Homo sapiens (Human)
Gene Name
zinc finger, DHHC-type containing 18
Gene Symbol
ZDHHC18
Synonyms
DHHC-18; DHHC18
Alternate Names
palmitoyltransferase ZDHHC18; zinc finger, DHHC domain containing 18; zinc finger DHHC domain-containing protein 18
Chromosome
1
Map Location
1p36.11
EC Number
2.3.1.225

Proteins

palmitoyltransferase ZDHHC18
Refseq ID NP_115659
Protein GI 45433499
UniProt ID Q9NUE0
mRNA ID NM_032283
Length 388
RefSeq Status VALIDATED
MKDCEYQQISPGAAPLPASPGARRPGPAASPTPGPGPAPPAAPAPPRWSSSGSGSGSGSGSLGRRPRRKWEVFPGRNRFYCGGRLMLAGHGGVFALTLLLILTTTGLFFVFDCPYLARKLTLAIPIIAAILFFFVMSCLLQTSFTDPGILPRATVCEAAALEKQIDNTGSSTYRPPPRTREVLINGQMVKLKYCFTCKMFRPPRTSHCSVCDNCVERFDHHCPWVGNCVGRRNYRFFYAFILSLSFLTAFIFACVVTHLTLRAQGSNFLSTLKETPASVLELVICFFSIWSILGLSGFHTYLVASNLTTNEDIKGSWSSKRGGEASVNPYSHKSIITNCCAVLCGPLPPSLIDRRGFVQSDTVLPSPIRSDEPACRAKPDASMVGGHP

Gene Information

Entrez Gene ID
84243
Gene Name
zinc finger, DHHC-type containing 18
Gene Symbol
ZDHHC18
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 IDA:UniProt C Golgi apparatus
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0016409 IDA:UniProt F palmitoyltransferase activity
GO:0019706 IEA:UniProtKB-EC F protein-cysteine S-palmitoyltransferase activity
GO:0008270 IEA:InterPro F zinc ion binding
GO:0034613 IEA:Ensembl P cellular protein localization
GO:0018345 IDA:UniProt P protein palmitoylation

Domain Information

InterPro Annotations

Accession Description
IPR001594 Zinc finger, DHHC-type, palmitoyltransferase

UniProt Annotations

Entry Information

Gene Name
zinc finger, DHHC-type containing 18
Protein Entry
ZDH18_HUMAN
UniProt ID
Q9NUE0
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NUE0-1; Sequence=Displayed; Name=2; IsoId=Q9NUE0-2; Sequence=VSP_056000; Note=No experimental confirmation available.;
Catalytic Activity Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.
Domain The DHHC domain is required for palmitoyltransferase activity.
Function Has palmitoyltransferase activity towards HRAS and LCK.
Sequence Caution Sequence=CAI21624.1; Type=Erroneous initiation; Evidence= ;
Similarity Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
Similarity Contains 1 DHHC-type zinc finger.
Subcellular Location Membrane ; Multi-pass membrane protein .

Identical and Related Proteins

Unique RefSeq proteins for LMP004744 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
45433499 RefSeq NP_115659 388 palmitoyltransferase ZDHHC18

Identical Sequences to LMP004744 proteins

Reference Database Accession Length Protein Name
GI:45433499 GenBank AAH66776.1 388 Zinc finger, DHHC-type containing 18 [Homo sapiens]
GI:45433499 GenBank EAX07788.1 388 zinc finger, DHHC-type containing 18, isoform CRA_a [Homo sapiens]
GI:45433499 GenBank ACN08154.1 388 Sequence 9 from patent US 7488592
GI:45433499 GenBank AED39506.1 388 Sequence 9 from patent US 7883860
GI:45433499 GenBank AGJ46269.1 388 Sequence 40 from patent US 8404655
GI:45433499 GenBank AHD71199.1 388 Sequence 4667 from patent US 8586006

Related Sequences to LMP004744 proteins

Reference Database Accession Length Protein Name
GI:45433499 GenBank EAX07789.1 398 zinc finger, DHHC-type containing 18, isoform CRA_b [Homo sapiens]
GI:45433499 RefSeq XP_003891447.1 388 PREDICTED: palmitoyltransferase ZDHHC18 [Papio anubis]
GI:45433499 RefSeq XP_007978066.1 415 PREDICTED: palmitoyltransferase ZDHHC18 isoform X1 [Chlorocebus sabaeus]
GI:45433499 RefSeq XP_007978067.1 396 PREDICTED: palmitoyltransferase ZDHHC18 isoform X2 [Chlorocebus sabaeus]
GI:45433499 RefSeq XP_007978068.1 388 PREDICTED: palmitoyltransferase ZDHHC18 isoform X3 [Chlorocebus sabaeus]
GI:45433499 RefSeq XP_007978070.1 388 PREDICTED: palmitoyltransferase ZDHHC18 isoform X4 [Chlorocebus sabaeus]