Gene/Proteome Database (LMPD)
Proteins
| carboxylesterase 1D precursor | |
|---|---|
| Refseq ID | NP_444430 |
| Protein GI | 117553604 |
| UniProt ID | Q8VCT4 |
| mRNA ID | NM_053200 |
| Length | 565 |
| RefSeq Status | VALIDATED |
| MGLYPLIWLSLAACTAWGYPSSPPVVNTVKGKVLGKYVNLEGFTQPVAVFLGVPFAKPPLGSLRFAPPQPAEPWSFVKNTTSYPPMCSQDAVGGQVLSELFTNRKENIPLQFSEDCLYLNIYTPADLTKNSRLPVMVWIHGGGLVVGGASTYDGLALSAHENVVVVTIQYRLGIWGFFSTGDEHSRGNWGHLDQVAALRWVQDNIANFGGNPGSVTIFGESAGGFSVSVLVLSPLAKNLFHRAISESGVSLTAALITTDVKPIAGLVATLSGCKTTTSAVMVHCLRQKTEDELLETSLKLNLFKLDLLGNPKESYPFLPTVIDGVVLPKAPEEILAEKSFSTVPYIVGINKQEFGWIIPTLMGYPLAEGKLDQKTANSLLWKSYPTLKISENMIPVVAEKYLGGTDDLTKKKDLFQDLMADVVFGVPSVIVSRSHRDAGASTYMYEFEYRPSFVSAMRPKAVIGDHGDEIFSVFGSPFLKDGASEEETNLSKMVMKFWANFARNGNPNGGGLPHWPEYDQKEGYLKIGASTQAAQRLKDKEVSFWAELRAKESAQRPSHREHVEL | |
| sig_peptide: 1..18 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1966 peptide sequence: MGLYPLIWLSLAACTAWG mat_peptide: 19..565 product: Carboxylesterase 1D experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q8VCT4.1) calculated_mol_wt: 59840 peptide sequence: YPSSPPVVNTVKGKVLGKYVNLEGFTQPVAVFLGVPFAKPPLGSLRFAPPQPAEPWSFVKNTTSYPPMCSQDAVGGQVLSELFTNRKENIPLQFSEDCLYLNIYTPADLTKNSRLPVMVWIHGGGLVVGGASTYDGLALSAHENVVVVTIQYRLGIWGFFSTGDEHSRGNWGHLDQVAALRWVQDNIANFGGNPGSVTIFGESAGGFSVSVLVLSPLAKNLFHRAISESGVSLTAALITTDVKPIAGLVATLSGCKTTTSAVMVHCLRQKTEDELLETSLKLNLFKLDLLGNPKESYPFLPTVIDGVVLPKAPEEILAEKSFSTVPYIVGINKQEFGWIIPTLMGYPLAEGKLDQKTANSLLWKSYPTLKISENMIPVVAEKYLGGTDDLTKKKDLFQDLMADVVFGVPSVIVSRSHRDAGASTYMYEFEYRPSFVSAMRPKAVIGDHGDEIFSVFGSPFLKDGASEEETNLSKMVMKFWANFARNGNPNGGGLPHWPEYDQKEGYLKIGASTQAAQRLKDKEVSFWAELRAKESAQRPSHREHVEL | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005829 | IDA:UniProtKB | C | cytosol |
| GO:0005783 | TAS:ProtInc | C | endoplasmic reticulum |
| GO:0005788 | IDA:UniProtKB | C | endoplasmic reticulum lumen |
| GO:0005811 | IDA:UniProtKB | C | lipid particle |
| GO:0052689 | IDA:UniProtKB | F | carboxylic ester hydrolase activity |
| GO:0030339 | IEA:UniProtKB-EC | F | fatty-acyl-ethyl-ester synthase activity |
| GO:0004771 | IDA:UniProtKB | F | sterol esterase activity |
| GO:0004806 | IDA:UniProtKB | F | triglyceride lipase activity |
| GO:0006637 | TAS:ProtInc | P | acyl-CoA metabolic process |
| GO:0046464 | IDA:UniProtKB | P | acylglycerol catabolic process |
| GO:0016042 | NAS:UniProtKB | P | lipid catabolic process |
| GO:0009636 | TAS:ProtInc | P | response to toxic substance |
| GO:0019626 | IDA:MGI | P | short-chain fatty acid catabolic process |
| GO:0034379 | IMP:MGI | P | very-low-density lipoprotein particle assembly |
Domain Information
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | A carboxylic ester + H(2)O = an alcohol + a carboxylate. {ECO:0000255|PROSITE-ProRule:PRU10039, ECO:0000269|PubMed:15269189}. |
| Catalytic Activity | A long-chain-fatty-acyl ethyl ester + H(2)O = a long-chain-fatty acid + ethanol. |
| Caution | Was originally thought to originate from human. |
| Function | Major lipase in white adipose tissue. Involved in the metabolism of xenobiotics and of natural substrates. Hydrolyzes triacylglycerols and monoacylglycerols, with a preference for monoacylglycerols. The susceptibility of the substrate increases with decreasing acyl chain length of the fatty acid moiety. Catalyzes the synthesis of fatty acid ethyl esters. |
| Induction | By di-(2-ethylhexyl) phthalate. |
| Similarity | Belongs to the type-B carboxylesterase/lipase family. |
| Subcellular Location | Endoplasmic reticulum lumen . Cytoplasm, cytosol . Lipid droplet . |
| Subunit | Homotrimer. |
| Tissue Specificity | Highest expression occurs in liver with lower levels in adipose tissue, kidney, heart, intestine, lung, testis and thymus. {ECO:0000269|PubMed:11470237, ECO:0000269|PubMed:15269189}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP004709 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 117553604 | RefSeq | NP_444430 | 565 | carboxylesterase 1D precursor |
Identical Sequences to LMP004709 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:117553604 | DBBJ | BAC37439.1 | 565 | unnamed protein product [Mus musculus] |
| GI:117553604 | GenBank | AAH19198.1 | 565 | Carboxylesterase 3 [Mus musculus] |
| GI:117553604 | SwissProt | Q8VCT4.1 | 565 | RecName: Full=Carboxylesterase 1D; AltName: Full=Carboxylesterase 3; AltName: Full=Fatty acid ethyl ester synthase; Short=FAEE synthase; AltName: Full=Triacylglycerol hydrolase; Short=TGH; Flags: Precursor [Mus musculus] |
Related Sequences to LMP004709 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:117553604 | DBBJ | BAA84996.1 | 567 | brain carboxylesterase hBr3 [Homo sapiens] |
| GI:117553604 | DBBJ | BAB60698.1 | 565 | carboxylesterase MH1 [Mus musculus] |
| GI:117553604 | EMBL | CAA46391.1 | 565 | carboxylesterase [Rattus rattus] |
| GI:117553604 | GenBank | AAD49369.1 | 565 | carboxylesterase, partial [Rattus norvegicus] |
| GI:117553604 | GenBank | AAK58067.1 | 565 | triacylglycerol hydrolase [Mus musculus] |
| GI:117553604 | GenBank | EDL11096.1 | 576 | mCG145172, partial [Mus musculus] |