Gene/Proteome Database (LMPD)

LMPD ID
LMP004693
Gene ID
23463
Species
Homo sapiens (Human)
Gene Name
isoprenylcysteine carboxyl methyltransferase
Gene Symbol
ICMT
Synonyms
HSTE14; MST098; MSTP098; PCCMT; PCMT; PPMT
Alternate Names
protein-S-isoprenylcysteine O-methyltransferase; prenylcysteine carboxyl methyltransferase; prenylated protein carboxyl methyltransferase; protein-S isoprenylcysteine O-methyltransferase
Chromosome
1
Map Location
1p36.21
EC Number
2.1.1.100
Summary
This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic reticulum. Alternative splicing may result in other transcript variants, but the biological validity of those transcripts has not been determined. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for ICMT

Proteins

protein-S-isoprenylcysteine O-methyltransferase
Refseq ID NP_036537
Protein GI 6912430
UniProt ID O60725
mRNA ID NM_012405
Length 284
RefSeq Status REVIEWED
MAGCAARAPPGSEARLSLATFLLGASVLALPLLTRAGLQGRTGLALYVAGLNALLLLLYRPPRYQIAIRACFLGFVFGCGTLLSFSQSSWSHFGWYMCSLSLFHYSEYLVTAVNNPKSLSLDSFLLNHSLEYTVAALSSWLEFTLENIFWPELKQITWLSVTGLLMVVFGECLRKAAMFTAGSNFNHVVQNEKSDTHTLVTSGVYAWFRHPSYVGWFYWSIGTQVMLCNPICGVSYALTVWRFFRDRTEEEEISLIHFFGEEYLEYKKRVPTGLPFIKGVKVDL

Gene Information

Entrez Gene ID
23463
Gene Name
isoprenylcysteine carboxyl methyltransferase
Gene Symbol
ICMT
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IDA:MGI C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0016020 TAS:ProtInc C membrane
GO:0008140 IEA:Ensembl F cAMP response element binding protein binding
GO:0004671 IEA:UniProtKB-EC F protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
GO:0003880 TAS:ProtInc F protein C-terminal carboxyl O-methyltransferase activity
GO:0006481 TAS:ProtInc P C-terminal protein methylation
GO:0006464 TAS:ProtInc P cellular protein modification process
GO:0001701 IEA:Ensembl P in utero embryonic development
GO:0001889 IEA:Ensembl P liver development
GO:0035264 IEA:Ensembl P multicellular organism growth
GO:0008284 IEA:Ensembl P positive regulation of cell proliferation
GO:0006612 TAS:ProtInc P protein targeting to membrane
GO:0046578 IEA:Ensembl P regulation of Ras protein signal transduction

KEGG Pathway Links

KEGG Pathway ID Description
hsa00900 Terpenoid backbone biosynthesis
ko00900 Terpenoid backbone biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR007269 Isoprenylcysteine carboxyl methyltransferase
IPR025770 Protein-S-isoprenylcysteine O-methyltransferase

UniProt Annotations

Entry Information

Gene Name
isoprenylcysteine carboxyl methyltransferase
Protein Entry
ICMT_HUMAN
UniProt ID
O60725
Species
Human

Comments

Comment Type Description
Catalytic Activity S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C- terminal S-farnesyl-L-cysteine methyl ester. {ECO
Cofactor Name=Zn(2+); Xref=ChEBI
Function Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.
Similarity Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.
Subcellular Location Endoplasmic reticulum membrane ; Multi-pass membrane protein .
Tissue Specificity Ubiquitously expressed. Expressed at higher levels in the cerebellum and putamen than in other brain regions. Abundant expression seen in the Purkinje cells and pontine neurons.

Identical and Related Proteins

Unique RefSeq proteins for LMP004693 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6912430 RefSeq NP_036537 284 protein-S-isoprenylcysteine O-methyltransferase

Identical Sequences to LMP004693 proteins

Reference Database Accession Length Protein Name
GI:6912430 DBBJ BAJ20741.1 284 isoprenylcysteine carboxyl methyltransferase, partial [synthetic construct]
GI:6912430 GenBank EAW71523.1 284 isoprenylcysteine carboxyl methyltransferase, isoform CRA_a [Homo sapiens]
GI:6912430 GenBank AHD77596.1 284 Sequence 23725 from patent US 8586006
GI:6912430 GenBank AIC50963.1 284 ICMT, partial [synthetic construct]
GI:6912430 GenBank AIC62711.1 284 ICMT, partial [synthetic construct]
GI:6912430 RefSeq XP_005263494.1 284 PREDICTED: protein-S-isoprenylcysteine O-methyltransferase isoform X1 [Homo sapiens]

Related Sequences to LMP004693 proteins

Reference Database Accession Length Protein Name
GI:6912430 GenBank AAX36998.1 285 isoprenylcysteine carboxyl methyltransferase, partial [synthetic construct]
GI:6912430 GenBank ACM82155.1 298 Sequence 7653 from patent US 6812339
GI:6912430 GenBank JAA04560.1 284 isoprenylcysteine carboxyl methyltransferase [Pan troglodytes]
GI:6912430 GenBank JAA19294.1 284 isoprenylcysteine carboxyl methyltransferase [Pan troglodytes]
GI:6912430 GenBank JAA24828.1 284 isoprenylcysteine carboxyl methyltransferase [Pan troglodytes]
GI:6912430 GenBank JAA40836.1 284 isoprenylcysteine carboxyl methyltransferase [Pan troglodytes]