Gene/Proteome Database (LMPD)

LMPD ID
LMP004575
Gene ID
26301
Species
Homo sapiens (Human)
Gene Name
globoside alpha-1,3-N-acetylgalactosaminyltransferase 1
Gene Symbol
GBGT1
Synonyms
A3GALNT; FS; UNQ2513
Chromosome
9
Map Location
9q34.13-q34.3
EC Number
2.4.1.-
Summary
This gene encodes a glycosyltransferase that plays a role in the synthesis of Forssman glycolipid (FG), a member of the globoseries glycolipid family. Glycolipids such as FG form attachment sites for the binding of pathogens to cells; expression of this protein may determine host tropism to microorganisms. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Orthologs
View orthologs and multiple alignments for GBGT1

Proteins

globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 isoform 1
Refseq ID NP_068836
Protein GI 32484985
UniProt ID Q8N5D6
mRNA ID NM_021996
Length 347
RefSeq Status REVIEWED
MHRRRLALGLGFCLLAGTSLSVLWVYLENWLPVSYVPYYLPCPEIFNMKLHYKREKPLQPVVWSQYPQPKLLEHRPTQLLTLTPWLAPIVSEGTFNPELLQHIYQPLNLTIGVTVFAVGKYTHFIQSFLESAEEFFMRGYRVHYYIFTDNPAAVPGVPLGPHRLLSSIPIQGHSHWEETSMRRMETISQHIAKRAHREVDYLFCLDVDMVFRNPWGPETLGDLVAAIHPSYYAVPRQQFPYERRRVSTAFVADSEGDFYYGGAVFGGQVARVYEFTRGCHMAILADKANGIMAAWREESHLNRHFISNKPSKVLSPEYLWDDRKPQPPSLKLIRFSTLDKDISCLRS
globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 isoform 2
Refseq ID NP_001269558
Protein GI 544063402
UniProt ID Q8N5D6
mRNA ID NM_001282629
Length 294
RefSeq Status REVIEWED
MHRRRLALGLGFCLLAGTSLSVLWVYLENWLPVSYVPYYLPCPEIFNMKLHYKREKPLQPVVWSQYPQPKLLEHRPTQLLTLTPWLAPIVSEGTFNPELLQHIYQPLNLTIGVTVFAVGNPSWSQPRSSSCVGTGCTTTSSLTTLQPFPGSRWVPTGFSAPSPSRVTPTGRRHPCAGWRPSASTLLRGLTGRWTTSSALMWTWCFGTRGALRPWETWWLPFTQATTPFPASSSPMSAGVFPLPLWQTAKGTSIMVGQSSGGRWPGYMSLLGAATWPSWRTRPMASWLPGGRKAT
globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 isoform 3
Refseq ID NP_001269561
Protein GI 544063430
UniProt ID Q8N5D6
mRNA ID NM_001282632
Length 330
RefSeq Status REVIEWED
MHRRRLALGLGFCLLAGTSLSVLWVYLENWLPVSYVPYYLPCPEILSQYPQPKLLEHRPTQLLTLTPWLAPIVSEGTFNPELLQHIYQPLNLTIGVTVFAVGKYTHFIQSFLESAEEFFMRGYRVHYYIFTDNPAAVPGVPLGPHRLLSSIPIQGHSHWEETSMRRMETISQHIAKRAHREVDYLFCLDVDMVFRNPWGPETLGDLVAAIHPSYYAVPRQQFPYERRRVSTAFVADSEGDFYYGGAVFGGQVARVYEFTRGCHMAILADKANGIMAAWREESHLNRHFISNKPSKVLSPEYLWDDRKPQPPSLKLIRFSTLDKDISCLRS
globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 isoform 4
Refseq ID NP_001275501
Protein GI 544063430
UniProt ID Q8N5D6
mRNA ID NM_001288572
Length 330
RefSeq Status REVIEWED
MHRRRLALGLGFCLLAGTSLSVLWVYLENWLPVSYVPYYLPCPEILSQYPQPKLLEHRPTQLLTLTPWLAPIVSEGTFNPELLQHIYQPLNLTIGVTVFAVGKYTHFIQSFLESAEEFFMRGYRVHYYIFTDNPAAVPGVPLGPHRLLSSIPIQGHSHWEETSMRRMETISQHIAKRAHREVDYLFCLDVDMVFRNPWGPETLGDLVAAIHPSYYAVPRQQFPYERRRVSTAFVADSEGDFYYGGAVFGGQVARVYEFTRGCHMAILADKANGIMAAWREESHLNRHFISNKPSKVLSPEYLWDDRKPQPPSLKLIRFSTLDKDISCLRS
globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 isoform 5
Refseq ID NP_001275502
Protein GI 568384828
UniProt ID Q8N5D6
mRNA ID NM_001288573
Length 211
RefSeq Status REVIEWED
MRGYRVHYYIFTDNPAAVPGVPLGPHRLLSSIPIQGHSHWEETSMRRMETISQHIAKRAHREVDYLFCLDVDMVFRNPWGPETLGDLVAAIHPSYYAVPRQQFPYERRRVSTAFVADSEGDFYYGGAVFGGQVARVYEFTRGCHMAILADKANGIMAAWREESHLNRHFISNKPSKVLSPEYLWDDRKPQPPSLKLIRFSTLDKDISCLRS

Gene Information

Entrez Gene ID
26301
Gene Name
globoside alpha-1,3-N-acetylgalactosaminyltransferase 1
Gene Symbol
GBGT1
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 IEA:UniProtKB-KW C Golgi apparatus
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0047277 IEA:Ensembl F globoside alpha-N-acetylgalactosaminyltransferase activity
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0009247 TAS:ProtInc P glycolipid biosynthetic process
GO:0006486 IEA:UniProtKB-UniPathway P protein glycosylation

KEGG Pathway Links

KEGG Pathway ID Description
hsa00603 Glycosphingolipid biosynthesis - globo series
ko00603 Glycosphingolipid biosynthesis - globo series
hsa01100 Metabolic pathways

Domain Information

InterPro Annotations

Accession Description
IPR005076 Glycosyl transferase, family 6
IPR029044 Nucleotide-diphospho-sugar transferases

UniProt Annotations

Entry Information

Gene Name
globoside alpha-1,3-N-acetylgalactosaminyltransferase 1
Protein Entry
GBGT1_HUMAN
UniProt ID
Q8N5D6
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8N5D6-1; Sequence=Displayed; Name=2; IsoId=Q8N5D6-2; Sequence=VSP_013750; Note=No experimental confirmation available.; Name=3; IsoId=Q8N5D6-3; Sequence=VSP_055375; Note=No experimental confirmation available.;
Caution In contrast to its mouse or canine ortholog, it does not mediate the formation of Forssman glycolipid (also called Forssman antigen; FG), which does not exist in human. It is unknown whether it has no enzyme activity at all or has some distinct substrate specificity compared to the canine and mouse protein.
Cofactor Name=Mn(2+); Xref=ChEBI
Domain The conserved DXD motif is involved in cofactor binding. The manganese ion interacts with the beta-phosphate group of UDP and may also have a role in catalysis (By similarity).
Function Catalyzes the formation of some glycolipid via the addition of N-acetylgalactosamine (GalNAc) in alpha-1,3-linkage to some substrate. Glycolipids probably serve for adherence of some pathogens.
Pathway Protein modification; protein glycosylation.
Similarity Belongs to the glycosyltransferase 6 family.
Subcellular Location Golgi apparatus membrane ; Single-pass type II membrane protein .
Tissue Specificity Widely expressed. Expressed at higher level in placenta, ovary and peripheral blood leukocyte, whereas it is weakly expressed in liver, thymus, and testis.
Web Resource Name=Functional Glycomics Gateway - GTase; Note=Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_479";
Web Resource Name=GGDB; Note=GlycoGene database; URL="http://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=GBGT1";
Web Resource Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/gbgt1/";

Identical and Related Proteins

Unique RefSeq proteins for LMP004575 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
32484985 RefSeq NP_068836 347 globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 isoform 1
544063402 RefSeq NP_001269558 294 globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 isoform 2
544063430 RefSeq NP_001269561 330 globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 isoform 3
544063430 RefSeq NP_001275501 330 globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 isoform 4
568384828 RefSeq NP_001275502 211 globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 isoform 5

Identical Sequences to LMP004575 proteins

Reference Database Accession Length Protein Name
GI:32484985 DBBJ BAF84187.1 347 unnamed protein product [Homo sapiens]
GI:544063430 DBBJ BAH14061.1 330 unnamed protein product [Homo sapiens]
GI:544063430 DBBJ BAH14061.1 330 unnamed protein product [Homo sapiens]
GI:568384828 EMBL CAF86142.1 211 unnamed protein product [Homo sapiens]
GI:32484985 EMBL CCD30590.1 347 globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 [Homo sapiens]
GI:32484985 GenBank AAZ38721.1 347 globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 [Homo sapiens]
GI:544063402 GenBank EAW88043.1 294 globoside alpha-1,3-N-acetylgalactosaminyltransferase 1, isoform CRA_a [Homo sapiens]
GI:32484985 GenBank EAW88045.1 347 globoside alpha-1,3-N-acetylgalactosaminyltransferase 1, isoform CRA_c [Homo sapiens]
GI:568384828 GenBank EAW88046.1 211 globoside alpha-1,3-N-acetylgalactosaminyltransferase 1, isoform CRA_d [Homo sapiens]
GI:32484985 GenBank ACM84351.1 347 Sequence 9849 from patent US 6812339
GI:32484985 GenBank AEK15993.1 347 Sequence 113 from patent US 7977052

Related Sequences to LMP004575 proteins

Reference Database Accession Length Protein Name
GI:544063402 DBBJ BAC11106.1 294 unnamed protein product [Homo sapiens]
GI:32484985 DBBJ BAG36792.1 347 unnamed protein product [Homo sapiens]
GI:544063402 EMBL CAF85881.1 294 unnamed protein product [Homo sapiens]
GI:544063430 EMBL CCD30588.1 347 globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 [Homo sapiens]
GI:544063430 EMBL CCD30588.1 347 globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 [Homo sapiens]
GI:544063430 EMBL CCD30589.1 347 globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 [Homo sapiens]
GI:544063430 EMBL CCD30589.1 347 globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 [Homo sapiens]
GI:568384828 EMBL CCD30590.1 347 globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 [Homo sapiens]
GI:32484985 EMBL CCD30591.1 347 globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 [Homo sapiens]
GI:32484985 GenBank AAF06145.1 347 Forssman glycolipid synthetase [Homo sapiens]
GI:32484985 GenBank AAH32499.1 347 Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 [Homo sapiens]
GI:32484985 GenBank AAQ88542.1 347 glycosyltransferase [Homo sapiens]
GI:568384828 GenBank AAZ38721.1 347 globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 [Homo sapiens]
GI:568384828 GenBank EAW88045.1 347 globoside alpha-1,3-N-acetylgalactosaminyltransferase 1, isoform CRA_c [Homo sapiens]
GI:568384828 GenBank ACM84351.1 347 Sequence 9849 from patent US 6812339
GI:544063430 GenBank JAA13905.1 347 globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 [Pan troglodytes]
GI:544063430 GenBank JAA13905.1 347 globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 [Pan troglodytes]
GI:544063430 GenBank JAA27717.1 347 globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 [Pan troglodytes]
GI:544063430 GenBank JAA27717.1 347 globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 [Pan troglodytes]
GI:544063430 GenBank JAA40875.1 347 globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 [Pan troglodytes]
GI:544063430 GenBank JAA40875.1 347 globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 [Pan troglodytes]
GI:32484985 GenBank AIC56181.1 347 GBGT1, partial [synthetic construct]
GI:568384828 RefSeq NP_068836.2 347 globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 isoform 1 [Homo sapiens]
GI:544063402 RefSeq XP_008004005.1 294 PREDICTED: globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 isoform X6 [Chlorocebus sabaeus]
GI:544063402 RefSeq XP_009197013.1 294 PREDICTED: globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 isoform X6 [Papio anubis]
GI:544063430 RefSeq XP_009455867.1 382 PREDICTED: globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 isoform X8 [Pan troglodytes]
GI:544063430 RefSeq XP_009455867.1 382 PREDICTED: globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 isoform X8 [Pan troglodytes]
GI:544063402 RefSeq XP_009455874.1 346 PREDICTED: globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 isoform X15 [Pan troglodytes]
GI:544063402 RefSeq XP_010371108.1 316 PREDICTED: globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 isoform X3 [Rhinopithecus roxellana]
GI:568384828 SwissProt Q8N5D6.2 347 RecName: Full=Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1; AltName: Full=Forssman glycolipid synthase-like protein [Homo sapiens]