Gene/Proteome Database (LMPD)

LMPD ID
LMP004551
Gene ID
18201
Species
Mus musculus (Mouse)
Gene Name
neutral sphingomyelinase (N-SMase) activation associated factor
Gene Symbol
Nsmaf
Synonyms
AA959567; C630007J05; Fan
Alternate Names
protein FAN; factor associated with N-SMase activation; factor associated with neutral sphingomyelinase activation
Chromosome
4
Map Location
4 A1|4

Proteins

protein FAN
Refseq ID NP_035075
Protein GI 171906555
UniProt ID O35242
mRNA ID NM_010945
Length 920
RefSeq Status VALIDATED
MAFTRKRQREQQLQLYSKERFSLLLLNLEEYYFEQHTAFHVQHQGSQEERKIRGSLKICSKSVIFEPDAISQPILKIPLRDCLKIGKHGENGANKHFAKAKSWGISLIFSQIYFIKEHNIVAPYKIERGKMEYVFELEVSGKVEDVVETLLQLHRASCLDKLGDQMAMITAILQSRLARTSFDKNRFQSVSEKLHMECKAEMVTPLVTNPGHVCITDTSLYFQPLNGYPKPVVQITLQDVRRIYKRRHGLMPLGLEVFCTDDDLCSDIYLKFYEPQDRDDLYFYIATYLEHHAAEHTAESYMLQWQRGHLSNYQYLLHLNNLADRSCNDLSQYPVFPWIISDYSSPELDLSNPATFRDLSKPVGALNAERLERLLTRYQEMPEPRFMYGSHYSSPGYVLFYLVRIAPEYMLCLQNGRFDNADRMFNSIAETWKNCLDGATDFKELIPEFYDEDVSFLVNSLKLDLGKRQGGQMVDDVDLPAWASSPQDFLQKNKDALESGYVSEHLHEWIDLIFGYKQKGSEAIGAHNVFHPLTYEGGVDLNSIEDPDEKVAMLTQILEFGQTPKQLFVTPHPRRITPKFKSLSQASSYNASLTDSPVSPGEESFEDLTEESRTLAWSNIAKLQLHEQYKIHKEAVTGIAVSCNGSSVFTTSQDSTLKMFSKESKMLQRSISFSNMALSSCLLLPGDTTVISSSWDNNVYFYSIAFGRRQDTLMGHDDAVSKICWHNDRLYSGSWDSTVKVWSGVPAEMPGTKRHQFDLLAELEHDVSVNTINLNAVSTLLVSGTKEGMVNIWDLTTATLLHQTSCHSGTVCDAAFSPDSRHILSTGVDGCLNVIDVQTGMLISSMASEEPQRCFVWDGNSVLSGSRSGELLVWDLLGAKVSERIQGHTGAVTCMWMNEQCSSIITGGEDRQIMFWKLQY

Gene Information

Entrez Gene ID
18201
Gene Name
neutral sphingomyelinase (N-SMase) activation associated factor
Gene Symbol
Nsmaf
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005123 TAS:MGI F death receptor binding
GO:0016230 IEA:Ensembl F sphingomyelin phosphodiesterase activator activity
GO:0043065 IEA:Ensembl P positive regulation of apoptotic process

Domain Information

InterPro Annotations

Accession Description
IPR000409 BEACH domain
IPR004182 GRAM domain
IPR023362 PH-BEACH domain
IPR017986 WD40-repeat-containing domain
IPR015943 WD40/YVTN repeat-like-containing domain
IPR001680 WD40_repeat

UniProt Annotations

Entry Information

Gene Name
neutral sphingomyelinase (N-SMase) activation associated factor
Protein Entry
FAN_MOUSE
UniProt ID
O35242
Species
Mouse

Comments

Comment Type Description
Function Couples the p55 TNF-receptor (TNF-R55 / TNFR1) to neutral sphingomyelinase (N-SMASE). Specifically binds to the N- smase activation domain of TNF-R55. May regulate ceramide production by N-SMASE.
Similarity Contains 1 BEACH domain. {ECO:0000255|PROSITE- ProRule:PRU00026}.
Similarity Contains 1 GRAM domain. {ECO:0000305}.
Similarity Contains 6 WD repeats. {ECO:0000255|PROSITE- ProRule:PRU00221}.

Identical and Related Proteins

Unique RefSeq proteins for LMP004551 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
171906555 RefSeq NP_035075 920 protein FAN

Identical Sequences to LMP004551 proteins

Reference Database Accession Length Protein Name
GI:171906555 GenBank EDL05686.1 920 neutral sphingomyelinase (N-SMase) activation associated factor, isoform CRA_b [Mus musculus]
GI:171906555 GenBank AAI45962.1 920 Neutral sphingomyelinase (N-SMase) activation associated factor [Mus musculus]
GI:171906555 GenBank AAI45964.1 920 Neutral sphingomyelinase (N-SMase) activation associated factor [Mus musculus]
GI:171906555 SwissProt O35242.2 920 RecName: Full=Protein FAN; AltName: Full=Factor associated with neutral sphingomyelinase activation; Short=Factor associated with N-SMase activation [Mus musculus]

Related Sequences to LMP004551 proteins

Reference Database Accession Length Protein Name
GI:171906555 GenBank AAB65394.1 920 FAN protein [Mus musculus]
GI:171906555 RefSeq NP_852054.1 920 protein FAN [Rattus norvegicus]
GI:171906555 RefSeq XP_006537725.1 956 PREDICTED: protein FAN isoform X1 [Mus musculus]
GI:171906555 RefSeq XP_006537726.1 949 PREDICTED: protein FAN isoform X2 [Mus musculus]
GI:171906555 RefSeq XP_006537727.1 927 PREDICTED: protein FAN isoform X3 [Mus musculus]
GI:171906555 RefSeq XP_008761766.1 920 PREDICTED: protein FAN isoform X1 [Rattus norvegicus]