Gene/Proteome Database (LMPD)

LMPD ID
LMP004521
Gene ID
57605
Species
Homo sapiens (Human)
Gene Name
phosphatidylinositol transfer protein, membrane-associated 2
Gene Symbol
PITPNM2
Synonyms
NIR-3; NIR3; RDGB2; RDGBA2
Chromosome
12
Map Location
12q24.31
Summary
PITPNM2 belongs to a family of membrane-associated phosphatidylinositol transfer domain-containing proteins that share homology with the Drosophila retinal degeneration B (rdgB) protein (Ocaka et al., 2005 [PubMed 15627748]).[supplied by OMIM, Mar 2008]
Orthologs
View orthologs and multiple alignments for PITPNM2

Proteins

membrane-associated phosphatidylinositol transfer protein 2 isoform 1
Refseq ID NP_065896
Protein GI 24308237
UniProt ID Q9BZ72
mRNA ID NM_020845
Length 1349
RefSeq Status VALIDATED
MIIKEYRIPLPMTVEEYRIAQLYMIQKKSRNETYGEGSGVEILENRPYTDGPGGSGQYTHKVYHVGMHIPSWFRSILPKAALRVVEESWNAYPYTRTRFTCPFVEKFSIDIETFYKTDAGENPDVFNLSPVEKNQLTIDFIDIVKDPVPHNEYKTEEDPKLFQSTKTQRGPLSENWIEEYKKQVFPIMCAYKLCKVEFRYWGMQSKIERFIHDTGLRRVMVRAHRQAWCWQDEWYGLSMENIRELEKEAQLMLSRKMAQFNEDGEEATELVKHEAVSDQTSGEPPEPSSSNGEPLVGRGLKKQWSTSSKSSRSSKRGASPSRHSISEWRMQSIARDSDESSDDEFFDAHEDLSDTEEMFPKDITKWSSNDLMDKIESPEPEDTQDGLYRQGAPEFRVASSVEQLNIIEDEVSQPLAAPPSKIHVLLLVLHGGTILDTGAGDPSSKKGDANTIANVFDTVMRVHYPSALGRLAIRLVPCPPVCSDAFALVSNLSPYSHDEGCLSSSQDHIPLAALPLLATSSPQYQEAVATVIQRANLAYGDFIKSQEGMTFNGQVCLIGDCVGGILAFDALCYSNQPVSESQSSSRRGSVVSMQDNDLLSPGILMNAAHCCGGGGGGGGGGGSSGGGGSSGGSSLESSRHLSRSNVDIPRSNGTEDPKRQLPRKRSDSSTYELDTIQQHQAFLSSLHASVLRTEPCSRHSSSSTMLDGTGALGRFDFEITDLFLFGCPLGLVLALRKTVIPALDVFQLRPACQQVYNLFHPADPSASRLEPLLERRFHALPPFSVPRYQRYPLGDGCSTLLADVLQTHNAAFQEHGAPSSPGTAPASRGFRRASEISIASQVSGMAESYTASSIAQKAPDALSHTPSVRRLSLLALPAPSPTTPGPHPPARKASPGLERAPGLPELDIGEVAAKWWGQKRIDYALYCPDALTAFPTVALPHLFHASYWESTDVVSFLLRQVMRHDNSSILELDGKEVSVFTPSKPREKWQRKRTHVKLRNVTANHRINDALANEDGPQVLTGRFMYGPLDMVTLTGEKVDVHIMTQPPSGEWLYLDTLVTNNSGRVSYTIPESHRLGVGVYPIKMVVRGDHTFADSYITVLPKGTEFVVFSIDGSFAASVSIMGSDPKVRAGAVDVVRHWQDLGYLIIYVTGRPDMQKQRVVAWLAQHNFPHGVVSFCDGLVHDPLRHKANFLKLLISELHLRVHAAYGSTKDVAVYSAISLSPMQIYIVGRPTKKLQQQCQFITDGYAAHLAQLKYSHRARPARNTATRMALRKGSFGLPGQGDFLRSRNHLLRTISAQPSGPSHRHERTQSQADGEQRGQRSMSVAAGCWGRAMTGRLEPGAAAGPK
membrane-associated phosphatidylinositol transfer protein 2 isoform 2
Refseq ID NP_001287730
Protein GI 663856157
UniProt ID Q9BZ72
mRNA ID NM_001300801
Length 1343
RefSeq Status VALIDATED
MIIKEYRIPLPMTVEEYRIAQLYMIQKKSRNETYGEGSGVEILENRPYTDGPGGSGQYTHKVYHVGMHIPSWFRSILPKAALRVVEESWNAYPYTRTRFTCPFVEKFSIDIETFYKTDAGENPDVFNLSPVEKNQLTIDFIDIVKDPVPHNEYKTEEDPKLFQSTKTQRGPLSENWIEEYKKQVFPIMCAYKLCKVEFRYWGMQSKIERFIHDTGLRRVMVRAHRQAWCWQDEWYGLSMENIRELEKEAQLMLSRKMAQFNEDGEEATELVKHEAVSDQTSGEPPEPSSSNGEPLVGRGLKKQWSTSSKSSRSSKRGASPSRHSISEWRMQSIARDSDESSDDEFFDAHEDLSDTEEMFPKDITKWSSNDLMDKIESPEPEDTQDGLYRQGAPEFRVASSVEQLNIIEDEVSQPLAAPPSKIHVLLLVLHGGTILDTGAGDPSSKKGDANTIANVFDTVMRVHYPSALGRLAIRLVPCPPVCSDAFALVSNLSPYSHDEGCLSSSQDHIPLAALPLLATSSPQYQEAVATVIQRANLAYGDFIKSQEGMTFNGQVCLIGDCVGGILAFDALCYSNQPVSESQSSSRRGSVVSMQDNDLLSPGILMNAAHCCGGGGGGGGGGGSSGGGGSSGGSSLESSRHLSRSNVDIPRSNGTEDPKRQLPRKRSDSSTYELDTIQQHQAFLSSLHASVLRTEPCSRHSSSSTMLDGTGALGRFDFEITDLFLFGCPLGLVLALRKTVIPALDVFQLRPACQQVYNLFHPADPSASRLEPLLERRFHALPPFSVPRYQRYPLGDGCSTLLVETVQRNPELVLEGGPLAPLPHGDGFLETSMPVPAPTWQDGPRPGCAESDVLQTHNAAFQEHGAPSSPGTAPASRGFRRASEISIASQVSGMAESYTASSIAQIAAKWWGQKRIDYALYCPDALTAFPTVALPHLFHASYWESTDVVSFLLRQVMRHDNSSILELDGKEVSVFTPSKPREKWQRKRTHVKLRNVTANHRINDALANEDGPQVLTGRFMYGPLDMVTLTGEKVDVHIMTQPPSGEWLYLDTLVTNNSGRVSYTIPESHRLGVGVYPIKMVVRGDHTFADSYITVLPKGTEFVVFSIDGSFAASVSIMGSDPKVRAGAVDVVRHWQDLGYLIIYVTGRPDMQKQRVVAWLAQHNFPHGVVSFCDGLVHDPLRHKANFLKLLISELHLRVHAAYGSTKDVAVYSAISLSPMQIYIVGRPTKKLQQQCQFITDGYAAHLAQLKYSHRARPARNTATRMALRKGSFGLPGQGDFLRSRNHLLRTISAQPSGPSHRHERTQSQADGEQRGQRSMSVAAGCWGRAMTGRLEPGAAAGPK

Gene Information

Entrez Gene ID
57605
Gene Name
phosphatidylinositol transfer protein, membrane-associated 2
Gene Symbol
PITPNM2
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 NAS:UniProtKB C integral component of membrane
GO:0043231 IDA:HPA C intracellular membrane-bounded organelle
GO:0005509 NAS:UniProtKB F calcium ion binding
GO:0008289 IEA:UniProtKB-KW F lipid binding
GO:0008152 NAS:UniProtKB P metabolic process
GO:0006810 IEA:InterPro P transport

Domain Information

InterPro Annotations

Accession Description
IPR004177 DDHD
IPR023214 HAD-like domain
IPR013209 LNS2, Lipin/Ned1/Smp2
IPR001666 Phosphatidylinositol transfer protein
IPR023393 START-like domain

UniProt Annotations

Entry Information

Gene Name
phosphatidylinositol transfer protein, membrane-associated 2
Protein Entry
Q9BZ72_HUMAN
UniProt ID
Q9BZ72
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9BZ72-1; Sequence=Displayed; Name=2; IsoId=Q9BZ72-2; Sequence=VSP_017962, VSP_017963; Note=No experimental confirmation available.; Name=3; IsoId=Q9BZ72-3; Sequence=VSP_017961;
Function Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro). Binds calcium ions.
Sequence Caution Sequence=BAA95981.2; Type=Erroneous initiation; Evidence= ;
Similarity Belongs to the PtdIns transfer protein family. PI transfer class IIA subfamily.
Similarity Contains 1 DDHD domain. {ECO
Subcellular Location Endomembrane system ; Peripheral membrane protein .
Subunit Interacts with PTK2B via its C-terminus.
Tissue Specificity Highly expressed in brain, heart, ovary, testis and thymus. Detected in small intestine, prostate, pancreas, skeletal muscle, liver, colon and placenta.

Identical and Related Proteins

Unique RefSeq proteins for LMP004521 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
24308237 RefSeq NP_065896 1349 membrane-associated phosphatidylinositol transfer protein 2 isoform 1
663856157 RefSeq NP_001287730 1343 membrane-associated phosphatidylinositol transfer protein 2 isoform 2

Identical Sequences to LMP004521 proteins

Reference Database Accession Length Protein Name
GI:663856157 DBBJ BAG11328.1 1343 phosphatidylinositol transfer protein, membrane-associated 2, partial [synthetic construct]
GI:24308237 GenBank AAK01445.1 1349 NIR3 [Homo sapiens]
GI:24308237 GenBank AAQ41229.1 1349 Sequence 6 from patent US 6576442
GI:663856157 GenBank EAW98384.1 1343 phosphatidylinositol transfer protein, membrane-associated 2, isoform CRA_b [Homo sapiens]
GI:24308237 GenBank EAW98386.1 1349 phosphatidylinositol transfer protein, membrane-associated 2, isoform CRA_d [Homo sapiens]
GI:24308237 SwissProt Q9BZ72.1 1349 RecName: Full=Membrane-associated phosphatidylinositol transfer protein 2; AltName: Full=Phosphatidylinositol transfer protein, membrane-associated 2; Short=PITPnm 2; AltName: Full=Pyk2 N-terminal domain-interacting receptor 3; Short=NIR-3 [Homo sapiens]

Related Sequences to LMP004521 proteins

Reference Database Accession Length Protein Name
GI:663856157 DBBJ BAA95981.2 1359 KIAA1457 protein, partial [Homo sapiens]
GI:24308237 RefSeq XP_003314044.1 1349 PREDICTED: membrane-associated phosphatidylinositol transfer protein 2 isoform X2 [Pan troglodytes]
GI:24308237 RefSeq XP_004054141.1 1340 PREDICTED: membrane-associated phosphatidylinositol transfer protein 2 [Gorilla gorilla gorilla]
GI:24308237 RefSeq XP_005253639.1 1397 PREDICTED: membrane-associated phosphatidylinositol transfer protein 2 isoform X1 [Homo sapiens]
GI:24308237 RefSeq XP_005253640.1 1397 PREDICTED: membrane-associated phosphatidylinositol transfer protein 2 isoform X2 [Homo sapiens]
GI:24308237 RefSeq XP_006719579.1 1397 PREDICTED: membrane-associated phosphatidylinositol transfer protein 2 isoform X6 [Homo sapiens]
GI:663856157 RefSeq XP_008962754.1 1356 PREDICTED: membrane-associated phosphatidylinositol transfer protein 2 isoform X1 [Pan paniscus]
GI:663856157 RefSeq XP_008962755.1 1356 PREDICTED: membrane-associated phosphatidylinositol transfer protein 2 isoform X1 [Pan paniscus]
GI:663856157 RefSeq XP_009180202.1 1340 PREDICTED: membrane-associated phosphatidylinositol transfer protein 2 isoform X5 [Papio anubis]
GI:24308237 RefSeq XP_009246649.1 1346 PREDICTED: membrane-associated phosphatidylinositol transfer protein 2 [Pongo abelii]
GI:663856157 RefSeq XP_009424784.1 1356 PREDICTED: membrane-associated phosphatidylinositol transfer protein 2 isoform X1 [Pan troglodytes]
GI:663856157 RefSeq XP_009424785.1 1343 PREDICTED: membrane-associated phosphatidylinositol transfer protein 2 isoform X3 [Pan troglodytes]