Gene/Proteome Database (LMPD)

LMPD ID
LMP004491
Gene ID
63874
Species
Homo sapiens (Human)
Gene Name
abhydrolase domain containing 4
Gene Symbol
ABHD4
Synonyms
ABH4
Alternate Names
abhydrolase domain-containing protein 4; alpha/beta-hydrolase 4; lyso-N-acylphosphatidylethanolamine lipase
Chromosome
14
Map Location
14q11.2
EC Number
3.1.1.-

Proteins

abhydrolase domain-containing protein 4
Refseq ID NP_071343
Protein GI 50658087
UniProt ID Q8TB40
mRNA ID NM_022060
Length 342
RefSeq Status VALIDATED
MADDLEQQSQGWLSSWLPTWRPTSMSQLKNVEARILQCLQNKFLARYVSLPNQNKIWTVTVSPEQNDRTPLVMVHGFGGGVGLWILNMDSLSARRTLHTFDLLGFGRSSRPAFPRDPEGAEDEFVTSIETWRETMGIPSMILLGHSLGGFLATSYSIKYPDRVKHLILVDPWGFPLRPTNPSEIRAPPAWVKAVASVLGRSNPLAVLRVAGPWGPGLVQRFRPDFKRKFADFFEDDTISEYIYHCNAQNPSGETAFKAMMESFGWARRPMLERIHLIRKDVPITMIYGSDTWIDTSTGKKVKMQRPDSYVRDMEIKGASHHVYADQPHIFNAVVEEICDSVD

Gene Information

Entrez Gene ID
63874
Gene Name
abhydrolase domain containing 4
Gene Symbol
ABHD4
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016787 IEA:UniProtKB-KW F hydrolase activity
GO:0016042 IEA:UniProtKB-KW P lipid catabolic process

Domain Information

InterPro Annotations

Accession Description
IPR029058 Alpha/Beta hydrolase fold
IPR000073 Alpha/beta hydrolase fold-1

UniProt Annotations

Entry Information

Gene Name
abhydrolase domain containing 4
Protein Entry
ABHD4_HUMAN
UniProt ID
Q8TB40
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8TB40-1; Sequence=Displayed; Name=2; IsoId=Q8TB40-2; Sequence=VSP_056924, VSP_056925; Note=No experimental confirmation available;
Caution Thr-291 is present instead of the conserved His which is expected to be an active site residue.
Function Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lysophosphatidylethanolamine and lysophosphatidylserine (By similarity).
Similarity Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily.

Identical and Related Proteins

Unique RefSeq proteins for LMP004491 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
50658087 RefSeq NP_071343 342 abhydrolase domain-containing protein 4

Identical Sequences to LMP004491 proteins

Reference Database Accession Length Protein Name
GI:50658087 GenBank JAA11687.1 342 abhydrolase domain containing 4 [Pan troglodytes]
GI:50658087 GenBank JAA22559.1 342 abhydrolase domain containing 4 [Pan troglodytes]
GI:50658087 GenBank AIC52089.1 342 ABHD4, partial [synthetic construct]
GI:50658087 GenBank AIC52090.1 342 ABHD4, partial [synthetic construct]
GI:50658087 RefSeq XP_004054950.1 342 PREDICTED: abhydrolase domain-containing protein 4 [Gorilla gorilla gorilla]
GI:50658087 RefSeq XP_009425734.1 342 PREDICTED: abhydrolase domain-containing protein 4 [Pan troglodytes]

Related Sequences to LMP004491 proteins

Reference Database Accession Length Protein Name
GI:50658087 DBBJ BAB14289.1 342 unnamed protein product [Homo sapiens]
GI:50658087 EMBL CAE90713.1 342 unnamed protein product [Homo sapiens]
GI:50658087 EMBL CBN68794.1 342 unnamed protein product [Homo sapiens]
GI:50658087 EMBL CBN69750.1 342 unnamed protein product [Homo sapiens]
GI:50658087 RefSeq XP_003260617.1 342 PREDICTED: abhydrolase domain-containing protein 4 [Nomascus leucogenys]
GI:50658087 RefSeq XP_005560854.1 342 PREDICTED: abhydrolase domain-containing protein 4-like isoform X1 [Macaca fascicularis]