Gene/Proteome Database (LMPD)
Proteins
| BRCA1-A complex subunit RAP80 isoform 1 | |
|---|---|
| Refseq ID | NP_035437 |
| Protein GI | 45597445 |
| UniProt ID | Q5U5Q9 |
| mRNA ID | NM_011307 |
| Length | 727 |
| RefSeq Status | VALIDATED |
| MPRRKKKIKEASESQNLEKKDLETSSCVSIKKKRRLEDLLIVISDSDGEETKEENGLQKTKTKQSNRSKCLAKRKVAHMSEEEQFALALKMSEQEAREVNNQEEKEEELLRKAIAESLNSCWSSAASATRSRPLAAELSSHSHQENTKDSGTTEGVWQLVPPSLCKGSHVSQGNEAEQRKEPWDHNENTEEEPVSGSSGSWDQSSQPVFENENVKCFDRCTGHLAEHTQCGKPQESTGSGYAFSKAVQGRGDTSRQCLPIPADTKGLQDTGGTVHYYWGIPFCPAGVDPNQYTNVILCQLEVYQKSLKMAQRQLVKKRGFGEPVLPRPPFLIQNECGQEDQTSDKNEGISEDMGDEAKEERQESRASVWHSETKDFQKSPIKSLKQKLLLEEEPTTSRGQSSQGLFVEETSEEGLKSSEGDNSVPTTQSIAALTSKRSLVLMPESSAEETTVCPETQLSFLEPLDLNREDSPDSRELPIEVRMAVGDKQVANREDCMKENPPPAVSSSTRVSCPLCNQDFPPTKIEQHAMYCNGLMEQETVLTRRRREAKNKSDGRTAAQPALDANRKEKCYLCKSLVPLGEYQCHVEACLQLAKVDREDGIEGTRRPRVCAPVEGKQQQRLKKSKDKGHSQGRLLSLLEQSEHRTTGVEKKPKYSEVRTFRMPSPEVEEASCSREMQSTLSQLNLNESPIKSFVPVSEATNCLVDFKEQFAFRSRTKSGRGRRRKS | |
| BRCA1-A complex subunit RAP80 isoform 2 | |
|---|---|
| Refseq ID | NP_001280589 |
| Protein GI | 652698318 |
| UniProt ID | Q5U5Q9 |
| mRNA ID | NM_001293660 |
| Length | 446 |
| RefSeq Status | VALIDATED |
| MPRRKKKIKEASESQNLEKKDLETSSCVSIKKKRRLEDLLIVISDSDGEETKEENGLQKTKTKQSNRSKCLAKRKVAHMSEEEQFALALKMSEQEAREVNNQEEKEEELLRKAIAESLNSSQGLFVEETSEEGLKSSEGDNSVPTTQSIAALTSKRSLVLMPESSAEETTVCPETQLSFLEPLDLNREDSPDSRELPIEVRMAVGDKQVANREDCMKENPPPAVSSSTRVSCPLCNQDFPPTKIEQHAMYCNGLMEQETVLTRRRREAKNKSDGRTAAQPALDANRKEKCYLCKSLVPLGEYQCHVEACLQLAKVDREDGIEGTRRPRVCAPVEGKQQQRLKKSKDKGHSQGRLLSLLEQSEHRTTGVEKKPKYSEVRTFRMPSPEVEEASCSREMQSTLSQLNLNESPIKSFVPVSEATNCLVDFKEQFAFRSRTKSGRGRRRKS | |
Gene Information
Entrez Gene ID
Gene Name
ubiquitin interaction motif containing 1
Gene Symbol
Species
Mus musculus
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0070531 | ISS:UniProtKB | C | BRCA1-A complex |
| GO:0005634 | ISS:UniProtKB | C | nucleus |
| GO:0070530 | ISS:UniProtKB | F | K63-linked polyubiquitin binding |
| GO:0042393 | ISS:UniProtKB | F | histone binding |
| GO:0046965 | IDA:MGI | F | retinoid X receptor binding |
| GO:0031572 | ISS:UniProtKB | P | G2 DNA damage checkpoint |
| GO:0006302 | ISS:UniProtKB | P | double-strand break repair |
| GO:0070537 | ISS:UniProtKB | P | histone H2A K63-linked deubiquitination |
| GO:0045892 | ISS:HGNC | P | negative regulation of transcription, DNA-templated |
| GO:0045739 | ISS:UniProtKB | P | positive regulation of DNA repair |
| GO:0010212 | ISS:UniProtKB | P | response to ionizing radiation |
| GO:0006351 | IEA:UniProtKB-KW | P | transcription, DNA-templated |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR003903 | Ubiquitin interacting motif |
UniProt Annotations
Entry Information
Gene Name
ubiquitin interaction motif containing 1
Protein Entry
Q5U5Q9_MOUSE
UniProt ID
Species
Mouse
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q5U5Q9-1; Sequence=Displayed; Name=2; IsoId=Q5U5Q9-2; Sequence=VSP_037267, VSP_037268; Note=No experimental confirmation available.; Name=3; IsoId=Q5U5Q9-3; Sequence=VSP_037266; Note=No experimental confirmation available.; |
| Domain | The Abraxas-interacting region (AIR) mediates the interaction with FAM175A/Abraxas. {ECO:0000250}. |
| Domain | The UIM-linker region between the 2 UIM repeats determines the selectivity for 'Lys-63'-linked ubiquitin. The length of the linker is important. The linker reduces the flexibility between the UIM repeats and promotes high-affinity and linkage-selective interactions (By similarity). {ECO:0000250}. |
| Function | Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1 (By similarity). {ECO:0000250}. |
| Interaction | P62991:Ubc; NbExp=2; IntAct=EBI-7068640, EBI-413074; |
| Ptm | Phosphorylated upon DNA damage by ATM or ATR. {ECO:0000250}. |
| Ptm | Sumoylated. {ECO:0000250}. |
| Sequence Caution | Sequence=AAH37092.1; Type=Erroneous initiation; Evidence={ECO:0000305}; |
| Similarity | Belongs to the RAP80 family. {ECO:0000305}. |
| Similarity | Contains 2 UIM (ubiquitin-interacting motif) repeats. {ECO:0000255|PROSITE-ProRule:PRU00213}. |
| Subcellular Location | Nucleus {ECO:0000250}. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs). {ECO:0000250}. |
| Subunit | Component of the BRCA1-A complex, at least composed of the BRCA1, BARD1, UIMC1/RAP80, FAM175A/Abraxas, BRCC3/BRCC36, BRE/BRCC45 and BABAM1/NBA1. In the BRCA1-A complex, interacts directly with FAM175A/Abraxas. Interacts with ESR1 and UBE2I (By similarity). Interacts with NR6A1 and TSP57. {ECO:0000250, ECO:0000269|PubMed:12954732, ECO:0000269|PubMed:7760852}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP004374 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 45597445 | RefSeq | NP_035437 | 727 | BRCA1-A complex subunit RAP80 isoform 1 |
| 652698318 | RefSeq | NP_001280589 | 446 | BRCA1-A complex subunit RAP80 isoform 2 |
Identical Sequences to LMP004374 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:45597445 | DBBJ | BAC35106.1 | 727 | unnamed protein product [Mus musculus] |
| GI:652698318 | DBBJ | BAE36094.1 | 446 | unnamed protein product [Mus musculus] |
| GI:45597445 | RefSeq | XP_006517229.1 | 727 | PREDICTED: BRCA1-A complex subunit RAP80 isoform X1 [Mus musculus] |
Related Sequences to LMP004374 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:652698318 | DBBJ | BAC35106.1 | 727 | unnamed protein product [Mus musculus] |
| GI:652698318 | DBBJ | BAC38875.1 | 727 | unnamed protein product [Mus musculus] |
| GI:45597445 | DBBJ | BAC38875.1 | 727 | unnamed protein product [Mus musculus] |
| GI:45597445 | GenBank | AAH40808.1 | 727 | Ubiquitin interaction motif containing 1 [Mus musculus] |
| GI:45597445 | GenBank | ABJ48466.1 | 716 | Sequence 4 from patent US 7115711 |
| GI:45597445 | GenBank | EDL41167.1 | 727 | retinoid X receptor interacting protein 110, isoform CRA_a [Mus musculus] |
| GI:652698318 | RefSeq | NP_035437.1 | 727 | BRCA1-A complex subunit RAP80 isoform 1 [Mus musculus] |
| GI:45597445 | RefSeq | XP_005355275.1 | 727 | PREDICTED: BRCA1-A complex subunit RAP80 isoform X2 [Microtus ochrogaster] |
| GI:652698318 | RefSeq | XP_005355276.1 | 446 | PREDICTED: BRCA1-A complex subunit RAP80 isoform X3 [Microtus ochrogaster] |
| GI:652698318 | RefSeq | XP_006517229.1 | 727 | PREDICTED: BRCA1-A complex subunit RAP80 isoform X1 [Mus musculus] |
| GI:652698318 | RefSeq | XP_006976872.1 | 451 | PREDICTED: BRCA1-A complex subunit RAP80 [Peromyscus maniculatus bairdii] |
| GI:45597445 | SwissProt | Q5U5Q9.2 | 727 | RecName: Full=BRCA1-A complex subunit RAP80; AltName: Full=Receptor-associated protein 80; AltName: Full=Ubiquitin interaction motif-containing protein 1 [Mus musculus] |