Gene/Proteome Database (LMPD)

LMPD ID
LMP004105
Gene ID
13121
Species
Mus musculus (Mouse)
Gene Name
cytochrome P450, family 51
Gene Symbol
Cyp51
Synonyms
AI426508; CYPLI; Cyp51a1; Ldm; P450-14DM; P450LI
Alternate Names
lanosterol 14-alpha demethylase; cytochrome P450LI; cytochrome P450, 51; cytochrome P45014DM; cytochrome P450 51A1; cytochrome P450-14DM; sterol 14-alpha demethylase; lanosterol 14-alpha-demethylase
Chromosome
5
Map Location
5 A2|5 2.3 cM
EC Number
1.14.13.70

Proteins

lanosterol 14-alpha demethylase
Refseq ID NP_064394
Protein GI 71061451
UniProt ID Q8K0C4
mRNA ID NM_020010
Length 503
RefSeq Status VALIDATED
MVLLGLLQSGGWVLGQAMEQVTGGNLLSTLLIACAFTLSLVYLFRLAVGHMVQLPAGAKSPPHIYSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAAALLFNSKNEDLNAEEVYGRLTTPVFGKGVAYDVPNAIFLEQKKIIKSGLNIAHFKQYVPIIEKEAKEYFQSWGESGERNVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGFTHAAWLLPAWLPLPSFRRRDRAHREIKNIFYKAIQKRRLSKEPAEDILQTLLDSTYKDGRPLTDEEISGMLIGLLLAGQHTSSTTSAWMGFFLAKDKPLQEKCYLEQKAVCGEDLPPLTYDQLKDLNLLDRCIKETLRLRPPIMTMMRMAKTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWAERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCVGENFAYVQIKTIWSTMLRLYEFDLINGYFPTVNYTTMIHTPENPVIRYKRRSK

Gene Information

Entrez Gene ID
13121
Gene Name
cytochrome P450, family 51
Gene Symbol
Cyp51
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0020037 ISS:UniProtKB F heme binding
GO:0005506 IEA:InterPro F iron ion binding
GO:0008398 ISS:UniProtKB F sterol 14-demethylase activity
GO:0006695 TAS:MGI P cholesterol biosynthetic process
GO:0033488 IEA:Ensembl P cholesterol biosynthetic process via 24,25-dihydrolanosterol
GO:0070988 ISS:GOC P demethylation
GO:0006694 ISS:UniProtKB P steroid biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu00100 Steroid biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR001128 Cytochrome P450
IPR002403 Cytochrome P450, E-class, group IV
IPR017972 Cytochrome P450, conserved site

UniProt Annotations

Entry Information

Gene Name
cytochrome P450, family 51
Protein Entry
CP51A_MOUSE
UniProt ID
Q8K0C4
Species
Mouse

Comments

Comment Type Description
Catalytic Activity A 14-alpha-methylsteroid + 3 O(2) + 3 NADPH = a Delta(14)-steroid + formate + 3 NADP(+) + 4 H(2)O.
Cofactor Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
Function Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol. {ECO:0000250}.
Pathway Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 1/6.
Sequence Caution Sequence=AAF73986.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Similarity Belongs to the cytochrome P450 family. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000305}. Microsome membrane {ECO:0000305}.

Identical and Related Proteins

Unique RefSeq proteins for LMP004105 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
71061451 RefSeq NP_064394 503 lanosterol 14-alpha demethylase

Identical Sequences to LMP004105 proteins

Reference Database Accession Length Protein Name
GI:71061451 DBBJ BAC26134.1 503 unnamed protein product [Mus musculus]
GI:71061451 DBBJ BAC36548.1 503 unnamed protein product [Mus musculus]
GI:71061451 DBBJ BAC25900.1 503 unnamed protein product [Mus musculus]
GI:71061451 GenBank AAH31813.1 503 Cytochrome P450, family 51 [Mus musculus]
GI:71061451 GenBank EDL14627.1 503 cytochrome P450, family 51 [Mus musculus]
GI:71061451 SwissProt Q8K0C4.1 503 RecName: Full=Lanosterol 14-alpha demethylase; Short=LDM; AltName: Full=CYPLI; AltName: Full=Cytochrome P450 51A1; AltName: Full=Cytochrome P450-14DM; Short=Cytochrome P45014DM; AltName: Full=Cytochrome P450LI; AltName: Full=Sterol 14-alpha demethylase [Mus musculus]

Related Sequences to LMP004105 proteins

Reference Database Accession Length Protein Name
GI:71061451 DBBJ BAA20354.1 503 lanosterol 14-demethylase [Rattus norvegicus]
GI:71061451 DBBJ BAC27231.1 503 unnamed protein product [Mus musculus]
GI:71061451 GenBank AAF74562.1 503 lanosterol 14-alpha-demethylase [Mus musculus]
GI:71061451 GenBank AAH87033.1 503 Cytochrome P450, subfamily 51 [Rattus norvegicus]
GI:71061451 GenBank EDL84353.1 503 cytochrome P450, subfamily 51 [Rattus norvegicus]
GI:71061451 SwissProt Q64654.1 503 RecName: Full=Lanosterol 14-alpha demethylase; Short=LDM; AltName: Full=CYPLI; AltName: Full=Cytochrome P450 51A1; AltName: Full=Cytochrome P450-14DM; Short=Cytochrome P45014DM; AltName: Full=Cytochrome P450LI; AltName: Full=Sterol 14-alpha demethylase [Rattus norvegicus]