Gene/Proteome Database (LMPD)

LMPD ID
LMP003713
Gene ID
221955
Species
Homo sapiens (Human)
Gene Name
diacylglycerol lipase, beta
Gene Symbol
DAGLB
Synonyms
DAGLBETA; KCCR13L
Alternate Names
sn1-specific diacylglycerol lipase beta; DGL-beta
Chromosome
7
Map Location
7p22.1
EC Number
3.1.1.-

Proteins

sn1-specific diacylglycerol lipase beta isoform 1
Refseq ID NP_631918
Protein GI 218931251
UniProt ID Q8NCG7
mRNA ID NM_139179
Length 672
RefSeq Status VALIDATED
MPGMVLFGRRWAIASDDLVFPGFFELVVRVLWWIGILTLYLMHRGKLDCAGGALLSSYLIVLMILLAVVICTVSAIMCVSMRGTICNPGPRKSMSKLLYIRLALFFPEMVWASLGAAWVADGVQCDRTVVNGIIATVVVSWIIIAATVVSIIIVFDPLGGKMAPYSSAGPSHLDSHDSSQLLNGLKTAATSVWETRIKLLCCCIGKDDHTRVAFSSTAELFSTYFSDTDLVPSDIAAGLALLHQQQDNIRNNQEPAQVVCHAPGSSQEADLDAELENCHHYMQFAAAAYGWPLYIYRNPLTGLCRIGGDCCRSRTTDYDLVGGDQLNCHFGSILHTTGLQYRDFIHVSFHDKVYELPFLVALDHRKESVVVAVRGTMSLQDVLTDLSAESEVLDVECEVQDRLAHKGISQAARYVYQRLINDGILSQAFSIAPEYRLVIVGHSLGGGAAALLATMLRAAYPQVRCYAFSPPRGLWSKALQEYSQSFIVSLVLGKDVIPRLSVTNLEDLKRRILRVVAHCNKPKYKILLHGLWYELFGGNPNNLPTELDGGDQEVLTQPLLGEQSLLTRWSPAYSFSSDSPLDSSPKYPPLYPPGRIIHLQEEGASGRFGCCSAAHYSAKWSHEAEFSKILIGPKMLTDHMPDILMRALDSVVSDRAACVSCPAQGVSSVDVA
sn1-specific diacylglycerol lipase beta isoform 2
Refseq ID NP_001136408
Protein GI 218931253
UniProt ID Q8NCG7
mRNA ID NM_001142936
Length 543
RefSeq Status VALIDATED
MPGMVLFGRRWAIASDDLVFPGFFELVVRVLWWIGILTLYLMHRGKLDCAGGALLSSYLIVLMILLAVVICTVSAIMCVSMRGTICNPGPRKSMSKLLYIRLALFFPEMVWASLGAAWVADGVQCDRTVVNGIIATVVVRTQIWCPATLRRASPCFISNRTISGTTKSLPRWSAMPQGAPSCRSRTTDYDLVGGDQLNCHFGSILHTTGLQYRDFIHVSFHDKVYELPFLVALDHRKESVVVAVRGTMSLQDVLTDLSAESEVLDVECEVQDRLAHKGISQAARYVYQRLINDGILSQAFSIAPEYRLVIVGHSLGGGAAALLATMLRAAYPQVRCYAFSPPRGLWSKALQEYSQSFIVSLVLGKDVIPRLSVTNLEDLKRRILRVVAHCNKPKYKILLHGLWYELFGGNPNNLPTELDGGDQEVLTQPLLGEQSLLTRWSPAYSFSSDSPLDSSPKYPPLYPPGRIIHLQEEGASGRFGCCSAAHYSAKWSHEAEFSKILIGPKMLTDHMPDILMRALDSVVSDRAACVSCPAQGVSSVDVA

Gene Information

Entrez Gene ID
221955
Gene Name
diacylglycerol lipase, beta
Gene Symbol
DAGLB
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005765 IDA:UniProt C lysosomal membrane
GO:0005886 IDA:UniProtKB C plasma membrane
GO:0016787 IEA:UniProtKB-KW F hydrolase activity
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0019369 IDA:UniProtKB P arachidonic acid metabolic process
GO:0007596 TAS:Reactome P blood coagulation
GO:0016042 IEA:UniProtKB-KW P lipid catabolic process
GO:0007405 IEA:Ensembl P neuroblast proliferation
GO:0042136 IEA:Ensembl P neurotransmitter biosynthetic process
GO:0030168 TAS:Reactome P platelet activation

KEGG Pathway Links

KEGG Pathway ID Description
hsa04723 Retrograde endocannabinoid signaling
ko04723 Retrograde endocannabinoid signaling

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_19308 Arachidonate production from DAG

Domain Information

InterPro Annotations

Accession Description
IPR029058 Alpha/Beta hydrolase fold
IPR002921 Fungal lipase-like domain

UniProt Annotations

Entry Information

Gene Name
diacylglycerol lipase, beta
Protein Entry
DGLB_HUMAN
UniProt ID
Q8NCG7
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8NCG7-1; Sequence=Displayed; Name=2; IsoId=Q8NCG7-2; Sequence=VSP_020245; Note=No experimental confirmation available.; Name=3; IsoId=Q8NCG7-3; Sequence=VSP_020246, VSP_020247; Note=No experimental confirmation available.; Name=4; IsoId=Q8NCG7-4; Sequence=VSP_043309; Note=No experimental confirmation available.;
Biophysicochemical Properties Kinetic parameters: KM=74.1 uM for diacylglycerol ; Vmax=3.45 nmol/min/mg enzyme ; pH dependence: Optimum pH is 7.0. ;
Cofactor Name=Ca(2+); Xref=ChEBI
Enzyme Regulation Inhibited by p-hydroxy-mercuri-benzoate and HgCl(2), but not to PMSF. Also inhibited by RHC80267, a drug that blocks 2-AG formation.
Function Catalyzes the hydrolysis of diacylglycerol (DAG) to 2- arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses.
Sequence Caution Sequence=BAB85017.1; Type=Erroneous initiation; Evidence= ;
Similarity Belongs to the AB hydrolase superfamily. Lipase family.
Subcellular Location Cell membrane ; Multi-pass membrane protein .

Identical and Related Proteins

Unique RefSeq proteins for LMP003713 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
218931251 RefSeq NP_631918 672 sn1-specific diacylglycerol lipase beta isoform 1
218931253 RefSeq NP_001136408 543 sn1-specific diacylglycerol lipase beta isoform 2

Identical Sequences to LMP003713 proteins

Reference Database Accession Length Protein Name
GI:218931251 DBBJ BAC11420.1 672 unnamed protein product [Homo sapiens]
GI:218931253 DBBJ BAG61052.1 543 unnamed protein product [Homo sapiens]
GI:218931251 EMBL CAF86385.1 672 unnamed protein product [Homo sapiens]
GI:218931251 EMBL CAH05554.1 672 unnamed protein product [Homo sapiens]
GI:218931251 GenBank EAL23721.1 672 KCCR13L [Homo sapiens]
GI:218931251 GenBank EAW55035.1 672 KCCR13L, isoform CRA_b [Homo sapiens]
GI:218931251 SwissProt Q8NCG7.2 672 RecName: Full=Sn1-specific diacylglycerol lipase beta; Short=DGL-beta; AltName: Full=KCCR13L [Homo sapiens]

Related Sequences to LMP003713 proteins

Reference Database Accession Length Protein Name
GI:218931251 DBBJ BAC11175.1 672 unnamed protein product [Homo sapiens]
GI:218931251 EMBL CAF85911.1 672 unnamed protein product [Homo sapiens]
GI:218931251 GenBank AAH27603.1 672 Diacylglycerol lipase, beta [Homo sapiens]
GI:218931251 GenBank AAY07226.1 717 Sequence 8 from patent US 6872560
GI:218931251 GenBank JAA30691.1 672 diacylglycerol lipase, beta [Pan troglodytes]
GI:218931251 GenBank AIC58017.1 672 DAGLB, partial [synthetic construct]
GI:218931253 RefSeq XP_003895752.1 542 PREDICTED: sn1-specific diacylglycerol lipase beta isoform X2 [Papio anubis]
GI:218931253 RefSeq XP_003934293.1 543 PREDICTED: sn1-specific diacylglycerol lipase beta isoform X2 [Saimiri boliviensis boliviensis]
GI:218931253 RefSeq XP_004268989.1 540 PREDICTED: sn1-specific diacylglycerol lipase beta isoform 2 [Orcinus orca]
GI:218931253 RefSeq XP_008016927.1 542 PREDICTED: sn1-specific diacylglycerol lipase beta isoform X5 [Chlorocebus sabaeus]
GI:218931253 RefSeq XP_008981812.1 543 PREDICTED: sn1-specific diacylglycerol lipase beta isoform X2 [Callithrix jacchus]
GI:218931253 RefSeq XP_010366048.1 542 PREDICTED: sn1-specific diacylglycerol lipase beta isoform X2 [Rhinopithecus roxellana]