LIPID MAPS

LMPD ID

LMP003430

Gene ID

242864

Species

Mus musculus (Mouse)

Gene Name

N-acyl phosphatidylethanolamine phospholipase D

Gene Symbol

Napepld

Synonyms

A530089G06; Mbldc1; NAPE-PLD

Alternate Names

N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D; NAPE-hydrolyzing phospholipase D; Metallo-beta-lactamase domain containing 1

Chromosome

5

Map Location

5 A3|5

EC Number

3.1.4.54

N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D
Refseq ID	NP_848843
Protein GI	30520157
UniProt ID	Q8BH82
mRNA ID	NM_178728
Length	396
RefSeq Status	PROVISIONAL
MDEYEDSQSPAPSYQYPKETLRKRQNSVQNSGGSVSSRFSRKSFKLDYRLEEDVTKSKKGKDGRFVNPWPTWKNISIPNVLRWLIMEKNHSGVPGSKEELDKELPVLKPYFVSDPEDAGVREAGLRVTWLGHATLMVEMDELIFLTDPMFSSRASPSQYMGPKRFRRPPCTISELPTIDAVLISHNHYDHLDYGSVLALNERFGSELRWFVPLGLLDWMQKCGCENVIELDWWEENCVPGHDKVTFVFTPSQHWCKRTLLDDNKVLWGSWSVLGPWSRFFFAGDTGYCPAFEEIGKRFGPFDLAAIPIGAYEPRWFMKYQHADPEDAVRIHIDLQTKRSVAIHWGTFALANEHYLEPPVKLNEALERYGLSCEDFFILKHGESRYLNTDDRAFEET

Entrez Gene ID

242864

Gene Name

N-acyl phosphatidylethanolamine phospholipase D

Gene Symbol

Napepld

Species

Mus musculus

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0070062	IEA:Ensembl	C	extracellular vesicular exosome
GO:0016020	IEA:UniProtKB-KW	C	membrane
GO:0070290	IEA:InterPro	F	N-acylphosphatidylethanolamine-specific phospholipase D activity
GO:0008270	IEA:InterPro	F	zinc ion binding
GO:0009395	IEA:UniProtKB-KW	P	phospholipid catabolic process

KEGG Pathway Links

KEGG Pathway ID	Description
ko04723	Retrograde endocannabinoid signaling
mmu04723	Retrograde endocannabinoid signaling

REACTOME Pathway Links

REACTOME Pathway ID	Description
5894090	Retinoid cycle disease events
5892894	The canonical retinoid cycle in rods (twilight vision)

InterPro Annotations

Accession	Description
IPR001279	Beta-lactamase-like
IPR024884	N-acyl-phosphatidylethanolamine-hydrolysing phospholipase D

Entry Information

Gene Name

N-acyl phosphatidylethanolamine phospholipase D

Protein Entry

NAPEP_MOUSE

UniProt ID

Q8BH82

Species

Mouse

Comments

Comment Type	Description
Catalytic Activity	An N-acylphosphatidylethanolamine + H(2)O = an N-acylethanolamine + a 1,2-diacylglycerol 3-phosphate.
Cofactor	Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250}; Note=Binds 1 or 2 zinc ions per subunit. {ECO:0000250};
Enzyme Regulation	Activity is stimulated by divalent cations. {ECO:0000250}.
Function	Hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce N-acylethanolamines (NAEs) and phosphatidic acid. Responsible for the generation of anandamide (N- arachidonoylethanolamine), the ligand of cannabinoid and vanilloid receptors. {ECO:0000269\|PubMed:14634025}.
Similarity	Belongs to the NAPE-PLD family. {ECO:0000305}.
Subcellular Location	Membrane {ECO:0000250}.
Subunit	Monomer. {ECO:0000250}.
Tissue Specificity	Widely expressed. Highest expression in brain, kidney and testis (at protein level). {ECO:0000269\|PubMed:14634025}.

Unique RefSeq proteins for LMP003430 (as displayed in Record Overview)

Protein GI	Database	Accession	Length	Protein Name
30520157	RefSeq	NP_848843	396	N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D

Identical Sequences to LMP003430 proteins

Reference	Database	Accession	Length	Protein Name
GI:30520157	DBBJ	BAE24749.1	396	unnamed protein product [Mus musculus]
GI:30520157	EMBL	CBX86076.1	396	unnamed protein product [Mus musculus]
GI:30520157	GenBank	EDL03200.1	396	cDNA sequence AB112350 [Mus musculus]
GI:30520157	RefSeq	XP_006535774.1	396	PREDICTED: N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform X3 [Mus musculus]
GI:30520157	RefSeq	XP_006535775.1	396	PREDICTED: N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform X4 [Mus musculus]
GI:30520157	SwissProt	Q8BH82.1	396	RecName: Full=N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D; Short=N-acyl phosphatidylethanolamine phospholipase D; Short=NAPE-PLD; Short=NAPE-hydrolyzing phospholipase D [Mus musculus]

Related Sequences to LMP003430 proteins

Reference	Database	Accession	Length	Protein Name
GI:30520157	DBBJ	BAC30857.1	395	unnamed protein product [Mus musculus]
GI:30520157	EMBL	CBX86082.1	396	unnamed protein product [Rattus norvegicus]
GI:30520157	GenBank	EDL99421.1	396	N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D [Rattus norvegicus]
GI:30520157	RefSeq	XP_006535772.1	462	PREDICTED: N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform X1 [Mus musculus]
GI:30520157	RefSeq	XP_006535773.1	404	PREDICTED: N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform X2 [Mus musculus]
GI:30520157	RefSeq	XP_008760861.1	396	PREDICTED: N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform X1 [Rattus norvegicus]