Gene/Proteome Database (LMPD)

LMPD ID
LMP002980
Gene ID
14073
Species
Mus musculus (Mouse)
Gene Name
fatty acid amide hydrolase
Gene Symbol
Faah
Synonyms
AW412498
Alternate Names
fatty-acid amide hydrolase 1; amide hydrolase; oleamide hydrolase 1; anandamide amidohydrolase 1; fatty acid amide hydrolase protein
Chromosome
4
Map Location
4 D1|4 53.08 cM
EC Number
3.5.1.99

Proteins

fatty-acid amide hydrolase 1
Refseq ID NP_034303
Protein GI 226443015
UniProt ID O08914
mRNA ID NM_010173
Length 579
RefSeq Status VALIDATED
MVLSEVWTALSGLSGVCLACSLLSAAVVLRWTRSQTARGAVTRARQKQRAGLETMDKAVQRFRLQNPDLDSEALLALPLLQLVQKLQSGELSPEAVLFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHASTLGLSLNEGVTSESDCVVVQVLKLQGAVPFVHTNVPQSMLSYDCSNPLFGQTMNPWKPSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKSCVYGQTAVQLSVGPMARDVDSLALCMKALLCEDLFRLDSTIPPLPFREEIYRSSRPLRVGYYETDNYTMPTPAMRRAVMETKQSLEAAGHTLVPFLPNNIPYALEVLSAGGLFSDGGCSFLQNFKGDFVDPCLGDLVLVLKLPRWFKKLLSFLLKPLFPRLAAFLNSMCPRSAEKLWELQHEIEMYRQSVIAQWKAMNLDVVLTPMLGPALDLNTPGRATGAISYTVLYNCLDFPAGVVPVTTVTAEDDAQMEHYKGYFGDMWDNILKKGMKKGIGLPVAVQCVALPWQEELCLRFMREVERLMTPEKRPS

Gene Information

Entrez Gene ID
14073
Gene Name
fatty acid amide hydrolase
Gene Symbol
Faah
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 IEA:UniProtKB-KW C Golgi apparatus
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0031090 ISS:UniProtKB C organelle membrane
GO:0047372 IMP:MGI F acylglycerol lipase activity
GO:0016884 IEA:InterPro F carbon-nitrogen ligase activity, with glutamine as amido-N-donor
GO:0017064 ISS:UniProtKB F fatty acid amide hydrolase activity
GO:0009062 ISS:UniProtKB P fatty acid catabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ko04723 Retrograde endocannabinoid signaling
mmu04723 Retrograde endocannabinoid signaling

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY6666-1 anandamide degradation

Domain Information

InterPro Annotations

Accession Description
IPR000120 Amidase
IPR023631 Amidase signature domain
IPR020556 Amidase, conserved site
IPR015830 Amidase, fungi type

UniProt Annotations

Entry Information

Gene Name
fatty acid amide hydrolase
Protein Entry
FAAH1_MOUSE
UniProt ID
O08914
Species
Mouse

Comments

Comment Type Description
Catalytic Activity Anandamide + H(2)O = arachidonic acid + ethanolamine.
Catalytic Activity Oleamide + H(2)O = oleic acid + NH(3).
Function Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates (By similarity). {ECO:0000250}.
Similarity Belongs to the amidase family. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein. Note=Seems to be associated with the endoplasmic reticulum and/or Golgi apparatus.
Subunit Homodimer. {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP002980 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
226443015 RefSeq NP_034303 579 fatty-acid amide hydrolase 1

Identical Sequences to LMP002980 proteins

Reference Database Accession Length Protein Name
GI:226443015 GenBank AAB58506.1 579 fatty acid amide hydrolase [Mus musculus]
GI:226443015 GenBank AAD11788.1 579 fatty acid amide hydrolase [Mus musculus]
GI:226443015 GenBank AAH52321.1 579 Fatty acid amide hydrolase [Mus musculus]
GI:226443015 GenBank EDL30627.1 579 fatty acid amide hydrolase, isoform CRA_c [Mus musculus]
GI:226443015 SwissProt O08914.1 579 RecName: Full=Fatty-acid amide hydrolase 1; AltName: Full=Anandamide amidohydrolase 1; AltName: Full=Oleamide hydrolase 1 [Mus musculus]

Related Sequences to LMP002980 proteins

Reference Database Accession Length Protein Name
GI:226443015 DBBJ BAC37695.1 579 unnamed protein product [Mus musculus]
GI:226443015 GenBank AAH06863.1 579 Fatty acid amide hydrolase [Mus musculus]
GI:226443015 GenBank AAE78250.1 581 Sequence 40 from patent US 6271015
GI:226443015 GenBank ACC29984.1 581 Sequence 40 from patent US 7348173
GI:226443015 GenBank AED78184.1 579 Sequence 4 from patent US 7915261
GI:226443015 GenBank AED82873.1 579 Sequence 4 from patent US 7919494