Gene/Proteome Database (LMPD)

LMPD ID
LMP002957
Gene ID
20773
Species
Mus musculus (Mouse)
Gene Name
serine palmitoyltransferase, long chain base subunit 2
Gene Symbol
Sptlc2
Synonyms
AI173915; LCB2; mKIAA0526
Alternate Names
serine palmitoyltransferase 2; LCB 2; LCB2a; SPT 2; serine-palmitoyl-CoA transferase 2; long chain base biosynthesis protein 2; long chain base biosynthesis protein 2a
Chromosome
12
Map Location
12|12 E
EC Number
2.3.1.50

Proteins

serine palmitoyltransferase 2
Refseq ID NP_035609
Protein GI 6755656
UniProt ID P97363
mRNA ID NM_011479
Length 560
RefSeq Status PROVISIONAL
MRPEPGGCCCRRPMRANGCVKNGEVRNGYLRSSTATVAAAGQIHHVTENGGLYKRPFNEAFEETPMLVAVLTYVGYGVLTLFGYLRDFLRHWRIEKCHHATEREEQKDFVSLYQDFENFYTRNLYMRIRDNWNRPICSVPGAKVDIMERKSHDYNWSFKYTGNIIKGVINMGSYNYLGFARNTGSCQEAAAEVLKEYGAGVCSTRQEIGNLDKHEELEKLVARFLGVEAAMTYGMGFATNSMNIPALVGKGCLILSDELNHASLVLGARLSGATIRIFKHNNMQSLEKLLKDAIVYGQPRTRRPWKKILILVEGIYSMEGSIVRLPEVIALKKKYKAYLYLDEAHSIGALGPSGRGVVDYFGLDPEDVDVMMGTFTKSFGASGGYIGGKKELIDYLRTHSHSAVYATSMSPPVMEQIITSMKCIMGQDGTSLGKECIQQLAENTRYFRRRLKEMGFIIYGNEDSPVVPLMLYMPAKIGAFGREMLKRNIGVVVVGFPATPIIESRARFCLSAAHTKEILDTALKEIDEVGDLLQLKYSRHRLVPLLDRPFDETTYEETED

Gene Information

Entrez Gene ID
20773
Gene Name
serine palmitoyltransferase, long chain base subunit 2
Gene Symbol
Sptlc2
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005739 IDA:MGI C mitochondrion
GO:0017059 ISA:MGI C serine C-palmitoyltransferase complex
GO:0030170 IEA:InterPro F pyridoxal phosphate binding
GO:0004758 IDA:MGI F serine C-palmitoyltransferase activity
GO:0046513 IMP:MGI P ceramide biosynthetic process
GO:0046511 IDA:MGI P sphinganine biosynthetic process
GO:0006686 IMP:MGI P sphingomyelin biosynthetic process
GO:0046512 IMP:MGI P sphingosine biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu00600 Sphingolipid metabolism

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY3DJ-12 ceramide biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR004839 Aminotransferase, class I/classII
IPR001917 Aminotransferase, class-II, pyridoxal-phosphate binding site
IPR015424 Pyridoxal phosphate-dependent transferase
IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1
IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2

UniProt Annotations

Entry Information

Gene Name
serine palmitoyltransferase, long chain base subunit 2
Protein Entry
SPTC2_MOUSE
UniProt ID
P97363
Species
Mouse

Comments

Comment Type Description
Catalytic Activity Palmitoyl-CoA + L-serine = CoA + 3-dehydro-D- sphinganine + CO(2).
Cofactor Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence={ECO:0000250};
Function Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC2-SPTSSB complex displays a preference for C18-CoA substrate (By similarity). {ECO:0000250}.
Pathway Lipid metabolism; sphingolipid metabolism.
Similarity Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:1317856}; Single-pass membrane protein {ECO:0000269|PubMed:1317856}.
Subunit Heterodimer with SPTLC1. Component of the serine palmitoyltransferase (SPT) complex, composed of LCB1/SPTLC1, LCB2 (SPTLC2 or SPTLC3) and ssPT (SPTSSA or SPTSSB) (By similarity). {ECO:0000250}.
Tissue Specificity Expressed in a variety of tissues.

Identical and Related Proteins

Unique RefSeq proteins for LMP002957 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6755656 RefSeq NP_035609 560 serine palmitoyltransferase 2

Identical Sequences to LMP002957 proteins

Reference Database Accession Length Protein Name
GI:6755656 DBBJ BAC32140.1 560 unnamed protein product [Mus musculus]
GI:6755656 DBBJ BAC40704.1 560 unnamed protein product [Mus musculus]
GI:6755656 DBBJ BAE35008.1 560 unnamed protein product [Mus musculus]
GI:6755656 GenBank AAH03227.1 560 Serine palmitoyltransferase, long chain base subunit 2 [Mus musculus]
GI:6755656 GenBank EDL02945.1 560 serine palmitoyltransferase, long chain base subunit 2, isoform CRA_a [Mus musculus]
GI:6755656 SwissProt P97363.2 560 RecName: Full=Serine palmitoyltransferase 2; AltName: Full=Long chain base biosynthesis protein 2; Short=LCB 2; AltName: Full=Long chain base biosynthesis protein 2a; Short=LCB2a; AltName: Full=Serine-palmitoyl-CoA transferase 2; Short=SPT 2 [Mus musculus]

Related Sequences to LMP002957 proteins

Reference Database Accession Length Protein Name
GI:6755656 GenBank AAC53504.1 560 serine palmitoyltransferase LCB2 subunit [Cricetulus griseus]
GI:6755656 GenBank AAI07663.1 560 Serine palmitoyltransferase, long chain base subunit 2 [Rattus norvegicus]
GI:6755656 GenBank EDL81646.1 562 protein-O-mannosyltransferase 2, isoform CRA_a [Rattus norvegicus]
GI:6755656 RefSeq NP_001032174.1 560 serine palmitoyltransferase 2 [Rattus norvegicus]
GI:6755656 RefSeq NP_001233609.1 560 serine palmitoyltransferase 2 [Cricetulus griseus]
GI:6755656 SwissProt O54694.1 560 RecName: Full=Serine palmitoyltransferase 2; AltName: Full=Long chain base biosynthesis protein 2; Short=LCB 2; AltName: Full=Long chain base biosynthesis protein 2a; Short=LCB2a; AltName: Full=Serine-palmitoyl-CoA transferase 2; Short=SPT 2 [Cricetulus griseus]