Gene/Proteome Database (LMPD)
LMPD ID
LMP002943
Gene ID
Species
Homo sapiens (Human)
Gene Name
sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
Gene Symbol
Synonyms
ISC1; NSMASE; NSMASE1
Alternate Names
sphingomyelin phosphodiesterase 2; N-SMase; lyso-PAF-PLC; neutral sphingomyelinase; lyso-platelet-activating factor-phospholipase C
Chromosome
6
Map Location
6q21
EC Number
3.1.4.12
Summary
This gene encodes a protein which was initially identified as a sphingomyelinase based on sequence similarity between bacterial sphingomyelinases and a yeast protein. Subsequent studies showed that its biological function is less likely to be as a sphingomyelinase and instead as a lysophospholipase. [provided by RefSeq, Oct 2009]
Orthologs
Proteins
| sphingomyelin phosphodiesterase 2 | |
|---|---|
| Refseq ID | NP_003071 |
| Protein GI | 92859618 |
| UniProt ID | O60906 |
| mRNA ID | NM_003080 |
| Length | 423 |
| RefSeq Status | VALIDATED |
| MKPNFSLRLRIFNLNCWGIPYLSKHRADRMRRLGDFLNQESFDLALLEEVWSEQDFQYLRQKLSPTYPAAHHFRSGIIGSGLCVFSKHPIQELTQHIYTLNGYPYMIHHGDWFSGKAVGLLVLHLSGMVLNAYVTHLHAEYNRQKDIYLAHRVAQAWELAQFIHHTSKKADVVLLCGDLNMHPEDLGCCLLKEWTGLHDAYLETRDFKGSEEGNTMVPKNCYVSQQELKPFPFGVRIDYVLYKAVSGFYISCKSFETTTGFDPHRGTPLSDHEALMATLFVRHSPPQQNPSSTHGPAERSPLMCVLKEAWTELGLGMAQARWWATFASYVIGLGLLLLALLCVLAAGGGAGEAAILLWTPSVGLVLWAGAFYLFHVQEVNGLYRAQAELQHVLGRAREAQDLGPEPQPALLLGQQEGDRTKEQ | |
Gene Information
Entrez Gene ID
Gene Name
sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005901 | IEA:Ensembl | C | caveola |
| GO:0005887 | TAS:ProtInc | C | integral component of plasma membrane |
| GO:0005886 | TAS:Reactome | C | plasma membrane |
| GO:0046872 | IEA:UniProtKB-KW | F | metal ion binding |
| GO:0004767 | TAS:ProtInc | F | sphingomyelin phosphodiesterase activity |
| GO:0097190 | TAS:Reactome | P | apoptotic signaling pathway |
| GO:0046513 | IEA:Ensembl | P | ceramide biosynthetic process |
| GO:0006687 | TAS:Reactome | P | glycosphingolipid metabolic process |
| GO:0048011 | TAS:Reactome | P | neurotrophin TRK receptor signaling pathway |
| GO:0009612 | IEA:Ensembl | P | response to mechanical stimulus |
| GO:0044281 | TAS:Reactome | P | small molecule metabolic process |
| GO:0006665 | TAS:Reactome | P | sphingolipid metabolic process |
| GO:0006684 | TAS:ProtInc | P | sphingomyelin metabolic process |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| hsa00600 | Sphingolipid metabolism |
BIOCYC Pathway Links
| BIOCYC Pathway ID | Description |
|---|---|
| PWY3DJ-11281 | sphingomyelin metabolism |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_13806 | Ceramide signalling |
| REACT_116105 | Glycosphingolipid metabolism |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR005135 | Endonuclease/exonuclease/phosphatase |
UniProt Annotations
Entry Information
Gene Name
sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
Protein Entry
NSMA_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Biophysicochemical Properties | pH dependence: Optimum pH is 6.5-7.5.; |
| Catalytic Activity | Sphingomyelin + H(2)O = N-acylsphingosine + phosphocholine. |
| Cofactor | Name=Mg(2+); Xref=ChEBI |
| Function | Converts sphingomyelin to ceramide. Hydrolyze 1-acyl-2- lyso-sn-glycero-3-phosphocholine (lyso-PC) and 1-O-alkyl-2-lyso- sn-glycero-3-phosphocholine (lyso-platelet-activating factor). The physiological substrate seems to be Lyso-PAF. |
| Pathway | Lipid metabolism; sphingolipid metabolism. |
| Similarity | Belongs to the neutral sphingomyelinase family. |
| Subcellular Location | Membrane; Multi-pass membrane protein. |
Identical and Related Proteins
Unique RefSeq proteins for LMP002943 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 92859618 | RefSeq | NP_003071 | 423 | sphingomyelin phosphodiesterase 2 |
Identical Sequences to LMP002943 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:92859618 | SwissProt | O60906.2 | 423 | RecName: Full=Sphingomyelin phosphodiesterase 2; AltName: Full=Lyso-platelet-activating factor-phospholipase C; Short=Lyso-PAF-PLC; AltName: Full=Neutral sphingomyelinase; Short=N-SMase; Short=nSMase [Homo sapiens] |
Related Sequences to LMP002943 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:92859618 | EMBL | CAA10995.1 | 423 | neutral sphingomyelinase [Homo sapiens] |
| GI:92859618 | GenBank | AAH00038.1 | 423 | Sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase) [Homo sapiens] |
| GI:92859618 | GenBank | EAW48346.1 | 423 | sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase) [Homo sapiens] |
| GI:92859618 | GenBank | ABM82805.1 | 423 | sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase) [synthetic construct] |
| GI:92859618 | GenBank | ADQ32367.1 | 423 | sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase), partial [synthetic construct] |
| GI:92859618 | GenBank | AIC55151.1 | 423 | SMPD2, partial [synthetic construct] |