Gene/Proteome Database (LMPD)

LMPD ID
LMP002907
Gene ID
14421
Species
Mus musculus (Mouse)
Gene Name
beta-1,4-N-acetyl-galactosaminyl transferase 1
Gene Symbol
B4galnt1
Synonyms
4933429D13Rik; Gal-NAc-T; GalNAc-T; GalNAcT; Galgt1; Ggm-2; Ggm2
Alternate Names
beta-1,4 N-acetylgalactosaminyltransferase 1; beta1,4GalNAC-T; GM2/GD2 synthase; (N-acetylneuraminyl)-galactosylglucosylceramide; UDP-N-acetyl-alpha-D-galactosamine:(N-acetylneuraminyl)-galactosylglucosylceramide-beta-1, 4-N-acetylgalactosaminyltransferase
Chromosome
10
Map Location
10 D3|10 74.5 cM
EC Number
2.4.1.92

Proteins

beta-1,4 N-acetylgalactosaminyltransferase 1 isoform 1
Refseq ID NP_032106
Protein GI 6679929
UniProt ID Q09200
mRNA ID NM_008080
Length 533
RefSeq Status VALIDATED
MRLDRRALYALVLLLACASLGLLYSSTRNAPSLPNPLALWSPPQGPPRLDLLDLAPEPRYAHIPVRIKEQVVGLLAQNNCSCESKGGSLPLPFLRQVRAVDLTKAFDAEELRAVSVAREQEYQAFLARSRSLADQLLIAPANSPLQYPLQGVEVQPLRSILVPGLSLQEASVQEIYQVNLSASLGTWDVAGEVTGVTLTGEGQPDLTLASPVLDKLNRQLQLVTYSSRSYQANTADTVRFSTKGHEVAFTILVRHPPNPRLYPPSSLPQGAEYNISALVTIATKTFLRYDRLRTLIASIRRFYPTVTIVIADDSDKPERISDPHVEHYFMPFGKGWFAGRNLAVSQVTTKYVLWVDDDFVFTARTRLEKLVDVLEKTPLDLVGGAVREISGYATTYRQLLSVEPGAPGLGNCFRQKQGFHHELVGFPSCVVTDGVVNFFLARTDKVRQVGFDPRLNRVAHLEFFLDGLGFLRVGSCSDVVVDHASKVKLPWTAKDPGAETYARYRYPGSLDQSQVAKHRLLFFKHRLQCMTAE
beta-1,4 N-acetylgalactosaminyltransferase 1 isoform 2
Refseq ID NP_082015
Protein GI 347543755
UniProt ID Q09200
mRNA ID NM_027739
Length 569
RefSeq Status VALIDATED
MAGLGYLREPRRRRGPESRPSRSLRAWSPLTLPHIRMRLDRRALYALVLLLACASLGLLYSSTRNAPSLPNPLALWSPPQGPPRLDLLDLAPEPRYAHIPVRIKEQVVGLLAQNNCSCESKGGSLPLPFLRQVRAVDLTKAFDAEELRAVSVAREQEYQAFLARSRSLADQLLIAPANSPLQYPLQGVEVQPLRSILVPGLSLQEASVQEIYQVNLSASLGTWDVAGEVTGVTLTGEGQPDLTLASPVLDKLNRQLQLVTYSSRSYQANTADTVRFSTKGHEVAFTILVRHPPNPRLYPPSSLPQGAEYNISALVTIATKTFLRYDRLRTLIASIRRFYPTVTIVIADDSDKPERISDPHVEHYFMPFGKGWFAGRNLAVSQVTTKYVLWVDDDFVFTARTRLEKLVDVLEKTPLDLVGGAVREISGYATTYRQLLSVEPGAPGLGNCFRQKQGFHHELVGFPSCVVTDGVVNFFLARTDKVRQVGFDPRLNRVAHLEFFLDGLGFLRVGSCSDVVVDHASKVKLPWTAKDPGAETYARYRYPGSLDQSQVAKHRLLFFKHRLQCMTAE
beta-1,4 N-acetylgalactosaminyltransferase 1 isoform 3
Refseq ID NP_001231546
Protein GI 347543757
UniProt ID Q3UN35
mRNA ID NM_001244617
Length 244
RefSeq Status VALIDATED
MRLDRRALYALVLLLACASLGLLYSSTRNAPSLPNPLALWSPPQGPPRLDLLDLAPEPRYAHIPVRIKEQVVGLLAQNNCSCESKGGSLPLPFLRQVRAVDLTKAFDAEELRAVSVAREQEYQAFLARSRSLADQLLIAPANSPLQYPLQGVEVQPLRSILVPGLSLQEASVQEIYQVNLSASLGTWDVAGEVTGVTLTGEGQPDLTLASPVLDKLNRQLQLVTYSSRSYQANTADTGGRPEEG

Gene Information

Entrez Gene ID
14421
Gene Name
beta-1,4-N-acetyl-galactosaminyl transferase 1
Gene Symbol
B4galnt1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0030173 IEA:InterPro C integral component of Golgi membrane
GO:0005886 IEA:Ensembl C plasma membrane
GO:0003947 IEA:UniProtKB-EC F (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity
GO:0001574 IMP:MGI P ganglioside biosynthetic process
GO:0006687 IMP:MGI P glycosphingolipid metabolic process
GO:0030259 IEA:InterPro P lipid glycosylation
GO:0019915 IGI:MGI P lipid storage
GO:0006486 IEA:UniProtKB-UniPathway P protein glycosylation
GO:0007283 IMP:MGI P spermatogenesis

KEGG Pathway Links

KEGG Pathway ID Description
ko00604 Glycosphingolipid biosynthesis - ganglio series
mmu00604 Glycosphingolipid biosynthesis - ganglio series
mmu01100 Metabolic pathways

Domain Information

InterPro Annotations

Accession Description
IPR011143 Ganglioside GM2 synthase
IPR001173 Glycosyltransferase 2-like
IPR029044 Nucleotide-diphospho-sugar transferases

UniProt Annotations

Entry Information

Gene Name
beta-1,4-N-acetyl-galactosaminyl transferase 1
Protein Entry
Q3UN35_MOUSE
UniProt ID
Q3UN35
Species
Mouse

Comments

Comment Type Description
Catalytic Activity UDP-N-acetyl-alpha-D-galactosamine + O-(N- acetyl-alpha-neuraminyl)-(2->3)-O-beta-D-galactopyranosyl-(1->4)- beta-D-glucopyranosyl-(1<->1)-ceramide = UDP + O-2-(acetylamino)- 2-deoxy-beta-D-galactopyranosyl-(1->4)-O-(N-acetyl-alpha- neuraminyl-(2->3))-O-beta-D-galactopyranosyl-(1->4)-beta-D- glucopyranosyl-(1<->1)-ceramide.
Developmental Stage Highest at day 7 of embryonic development after which it declines to its lowest levels at day 11 before increasing again.
Function Involved in the biosynthesis of gangliosides GM2, GD2 and GA2.
Pathway Protein modification; protein glycosylation.
Similarity Belongs to the glycosyltransferase 2 family. {ECO:0000305}.
Subcellular Location Golgi apparatus membrane; Single-pass type II membrane protein.
Subunit Homodimer; disulfide-linked. {ECO:0000250}.
Tissue Specificity Most abundant in brain, liver, lung, spleen and testis.
Web Resource Name=Functional Glycomics Gateway - GTase; Note=Beta-1,4 N-acetylgalactosaminyltransferase 1; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_mou_506";

Identical and Related Proteins

Unique RefSeq proteins for LMP002907 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6679929 RefSeq NP_032106 533 beta-1,4 N-acetylgalactosaminyltransferase 1 isoform 1
347543755 RefSeq NP_082015 569 beta-1,4 N-acetylgalactosaminyltransferase 1 isoform 2
347543757 RefSeq NP_001231546 244 beta-1,4 N-acetylgalactosaminyltransferase 1 isoform 3

Identical Sequences to LMP002907 proteins

Reference Database Accession Length Protein Name
GI:6679929 DBBJ BAE25913.1 533 unnamed protein product [Mus musculus]
GI:6679929 GenBank AAA65027.1 533 beta-1,4 N-acetylgalactosaminyltransferase [Mus musculus]
GI:347543757 GenBank AAH22180.1 244 B4galnt1 protein [Mus musculus]
GI:6679929 GenBank AAH36996.1 533 B4galnt1 protein [Mus musculus]
GI:6679929 GenBank AAH57199.1 533 Beta-1,4-N-acetyl-galactosaminyl transferase 1 [Mus musculus]
GI:347543757 GenBank EDL24473.1 244 beta-1,4-N-acetyl-galactosaminyl transferase 1, isoform CRA_a [Mus musculus]
GI:347543755 GenBank EDL24476.1 569 beta-1,4-N-acetyl-galactosaminyl transferase 1, isoform CRA_d [Mus musculus]
GI:6679929 RefSeq XP_006513282.1 533 PREDICTED: beta-1,4 N-acetylgalactosaminyltransferase 1 isoform X3 [Mus musculus]
GI:6679929 SwissProt Q09200.1 533 RecName: Full=Beta-1,4 N-acetylgalactosaminyltransferase 1; AltName: Full=(N-acetylneuraminyl)-galactosylglucosylceramide; AltName: Full=GM2/GD2 synthase; AltName: Full=GalNAc-T [Mus musculus]

Related Sequences to LMP002907 proteins

Reference Database Accession Length Protein Name
GI:6679929 DBBJ BAA04632.1 533 beta-4N-acetylgalactosaminyltransferase [Rattus norvegicus]
GI:347543757 DBBJ BAE25913.1 533 unnamed protein product [Mus musculus]
GI:6679929 GenBank AAA85496.1 533 beta-1,4 N-acetylgalactosaminyltransferase [Mus musculus]
GI:347543757 GenBank AAH36996.1 533 B4galnt1 protein [Mus musculus]
GI:347543755 GenBank AAH36996.1 533 B4galnt1 protein [Mus musculus]
GI:347543757 GenBank AAH57199.1 533 Beta-1,4-N-acetyl-galactosaminyl transferase 1 [Mus musculus]
GI:347543755 GenBank EDL24475.1 631 beta-1,4-N-acetyl-galactosaminyl transferase 1, isoform CRA_c, partial [Mus musculus]
GI:6679929 GenBank EDL24475.1 631 beta-1,4-N-acetyl-galactosaminyl transferase 1, isoform CRA_c, partial [Mus musculus]
GI:6679929 GenBank EDL24476.1 569 beta-1,4-N-acetyl-galactosaminyl transferase 1, isoform CRA_d [Mus musculus]
GI:347543755 GenBank EDM16492.1 569 beta-1,4-N-acetyl-galactosaminyl transferase 1, isoform CRA_a [Rattus norvegicus]
GI:6679929 RefSeq NP_082015.2 569 beta-1,4 N-acetylgalactosaminyltransferase 1 isoform 2 [Mus musculus]
GI:347543755 RefSeq XP_006513280.1 577 PREDICTED: beta-1,4 N-acetylgalactosaminyltransferase 1 isoform X1 [Mus musculus]
GI:6679929 RefSeq XP_006513280.1 577 PREDICTED: beta-1,4 N-acetylgalactosaminyltransferase 1 isoform X1 [Mus musculus]
GI:347543757 RefSeq XP_006513282.1 533 PREDICTED: beta-1,4 N-acetylgalactosaminyltransferase 1 isoform X3 [Mus musculus]
GI:347543757 RefSeq XP_006513283.1 309 PREDICTED: beta-1,4 N-acetylgalactosaminyltransferase 1 isoform X4 [Mus musculus]
GI:347543755 RefSeq XP_008763642.1 569 PREDICTED: beta-1,4 N-acetylgalactosaminyltransferase 1 isoform X2 [Rattus norvegicus]
GI:347543755 SwissProt Q09200.1 533 RecName: Full=Beta-1,4 N-acetylgalactosaminyltransferase 1; AltName: Full=(N-acetylneuraminyl)-galactosylglucosylceramide; AltName: Full=GM2/GD2 synthase; AltName: Full=GalNAc-T [Mus musculus]
GI:347543757 SwissProt Q09200.1 533 RecName: Full=Beta-1,4 N-acetylgalactosaminyltransferase 1; AltName: Full=(N-acetylneuraminyl)-galactosylglucosylceramide; AltName: Full=GM2/GD2 synthase; AltName: Full=GalNAc-T [Mus musculus]