Gene/Proteome Database (LMPD)

LMPD ID
LMP002731
Gene ID
19223
Species
Mus musculus (Mouse)
Gene Name
prostaglandin I2 (prostacyclin) synthase
Gene Symbol
Ptgis
Synonyms
Cyp8; Cyp8a1; Pgis
Alternate Names
prostacyclin synthase
Chromosome
2
Map Location
2 H3|2
EC Number
5.3.99.4

Proteins

prostacyclin synthase precursor
Refseq ID NP_032994
Protein GI 6679535
UniProt ID O35074
mRNA ID NM_008968
Length 501
RefSeq Status PROVISIONAL
MSWAALLGLLAVLLLLLLLLSRRRARRPGEPPLDLGSIPWLGHALEFGRDAASFLTRMKEKHGDIFTVLVGGRYVTVLLDPHSYDTVVWELRTRLDFHPYAIFLMERIFDLQLPNFNPSEEKARMKPTLMHRDLQALTEAMYTNLRTVLLGDSTEAGSGWQETGLLEFSYNALLSAGYLTLYGVEASPRTHESQAQDRVHSADVFHTFRQLDLLLPKLARGSLSAGDKDHACSVKNRLWKLLSPARLASRADRSSWLESYLRHLEEMGVSEEMQARALVLQLWATQGNMGPTAFWLLLFLLKNPEALAAVRAELKHTVWQAEQPVSQMTTLPQKILDSMPVLDSVLNETLRLTAAPFITREVMADLALPMADGREFSLRRGDRLLLFPFLSPQKDPEIYTEPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNQCLGKSYAINSIKQFVVLLLTHFDLELGSEDTEVPEFDLSRYGFGLMQPEEDVPIRYRARL
sig_peptide: 1..25 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2777 peptide sequence: MSWAALLGLLAVLLLLLLLLSRRRA

Gene Information

Entrez Gene ID
19223
Gene Name
prostaglandin I2 (prostacyclin) synthase
Gene Symbol
Ptgis
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005901 ISS:UniProtKB C caveola
GO:0005783 ISS:UniProtKB C endoplasmic reticulum
GO:0005615 ISS:UniProtKB C extracellular space
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005634 ISS:UniProtKB C nucleus
GO:0020037 IBA:RefGenome F heme binding
GO:0005506 IEA:InterPro F iron ion binding
GO:0004497 IEA:InterPro F monooxygenase activity
GO:0016705 IEA:InterPro F oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0008116 ISS:UniProtKB F prostaglandin-I synthase activity
GO:0097190 IEA:Ensembl P apoptotic signaling pathway
GO:0071456 ISS:UniProtKB P cellular response to hypoxia
GO:0071347 ISS:UniProtKB P cellular response to interleukin-1
GO:0071354 ISS:UniProtKB P cellular response to interleukin-6
GO:0032088 ISS:UniProtKB P negative regulation of NF-kappaB transcription factor activity
GO:0050728 ISS:UniProtKB P negative regulation of inflammatory response
GO:0045019 ISS:UniProtKB P negative regulation of nitric oxide biosynthetic process
GO:0045766 ISS:UniProtKB P positive regulation of angiogenesis
GO:1900119 ISS:UniProtKB P positive regulation of execution phase of apoptosis
GO:0035360 ISS:UniProtKB P positive regulation of peroxisome proliferator activated receptor signaling pathway
GO:0001516 ISS:UniProtKB P prostaglandin biosynthetic process
GO:0042981 IBA:RefGenome P regulation of apoptotic process

Domain Information

InterPro Annotations

Accession Description
IPR001128 Cytochrome P450
IPR002403 Cytochrome P450, E-class, group IV
IPR024204 Cytochrome P450, cholesterol 7-alpha-monooxygenase-type
IPR027286 Prostacyclin synthase

UniProt Annotations

Entry Information

Gene Name
prostaglandin I2 (prostacyclin) synthase
Protein Entry
PTGIS_MOUSE
UniProt ID
O35074
Species
Mouse

Comments

Comment Type Description
Catalytic Activity (5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15- hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-6,9-alpha-epoxy-11- alpha,15-dihydroxyprosta-5,13-dienoate.
Cofactor Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
Function Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2).
Similarity Belongs to the cytochrome P450 family. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane; Single-pass membrane protein.

Identical and Related Proteins

Unique RefSeq proteins for LMP002731 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6679535 RefSeq NP_032994 501 prostacyclin synthase precursor

Identical Sequences to LMP002731 proteins

Reference Database Accession Length Protein Name
GI:6679535 DBBJ BAA21717.1 501 prostacyclin synthase [Mus musculus]
GI:6679535 DBBJ BAC36403.1 501 unnamed protein product [Mus musculus]
GI:6679535 GenBank AAH62151.1 501 Prostaglandin I2 (prostacyclin) synthase [Mus musculus]
GI:6679535 GenBank EDL06504.1 501 prostaglandin I2 (prostacyclin) synthase, isoform CRA_b [Mus musculus]
GI:6679535 SwissProt O35074.1 501 RecName: Full=Prostacyclin synthase; AltName: Full=Prostaglandin I2 synthase [Mus musculus]

Related Sequences to LMP002731 proteins

Reference Database Accession Length Protein Name
GI:6679535 GenBank AAB02322.1 501 prostacyclin synthase [Rattus norvegicus]
GI:6679535 GenBank AAH61814.1 501 Prostaglandin I2 (prostacyclin) synthase [Rattus norvegicus]
GI:6679535 GenBank EDL96416.1 501 rCG32231 [Rattus norvegicus]
GI:6679535 GenBank ERE71536.1 501 prostacyclin synthase [Cricetulus griseus]
GI:6679535 RefSeq NP_113745.1 501 prostacyclin synthase precursor [Rattus norvegicus]
GI:6679535 SwissProt Q62969.1 501 RecName: Full=Prostacyclin synthase; AltName: Full=Prostaglandin I2 synthase [Rattus norvegicus]