Gene/Proteome Database (LMPD)

LMPD ID
LMP002699
Gene ID
7356
Species
Homo sapiens (Human)
Gene Name
secretoglobin, family 1A, member 1 (uteroglobin)
Gene Symbol
SCGB1A1
Synonyms
CC10; CC16; CCPBP; CCSP; UGB; UP-1; UP1
Alternate Names
uteroglobin; blastokinin; urine protein 1; urinary protein 1; clara cells 10 kDa secretory protein; clara cell phospholipid-binding protein
Chromosome
11
Map Location
11q12.3
Summary
This gene encodes a member of the secretoglobin family of small secreted proteins. The encoded protein has been implicated in numerous functions including anti-inflammation, inhibition of phospholipase A2 and the sequestering of hydrophobic ligands. Defects in this gene are associated with a susceptibility to asthma. [provided by RefSeq, May 2010]
Orthologs
View orthologs and multiple alignments for SCGB1A1

Proteins

uteroglobin precursor
Refseq ID NP_003348
Protein GI 4507809
UniProt ID P11684
mRNA ID NM_003357
Length 91
RefSeq Status REVIEWED
MKLAVTLTLVTLALCCSSASAEICPSFQRVIETLLMDTPSSYEAAMELFSPDQDMREAGAQLKKLVDTLPQKPRESIIKLMEKIAQSSLCN
sig_peptide: 1..21 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2097 peptide sequence: MKLAVTLTLVTLALCCSSASA mat_peptide: 22..91 product: uteroglobin calculated_mol_wt: 7915 peptide sequence: EICPSFQRVIETLLMDTPSSYEAAMELFSPDQDMREAGAQLKKLVDTLPQKPRESIIKLMEKIAQSSLCN

Gene Information

Entrez Gene ID
7356
Gene Name
secretoglobin, family 1A, member 1 (uteroglobin)
Gene Symbol
SCGB1A1
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005615 IEA:Ensembl C extracellular space
GO:0070062 IDA:UniProtKB C extracellular vesicular exosome
GO:0005635 IEA:Ensembl C nuclear envelope
GO:0005791 IEA:Ensembl C rough endoplasmic reticulum
GO:0030141 IEA:Ensembl C secretory granule
GO:0019834 IEA:UniProtKB-KW F phospholipase A2 inhibitor activity
GO:0007566 TAS:ProtInc P embryo implantation
GO:0007565 NAS:ProtInc P female pregnancy
GO:0042130 IEA:Ensembl P negative regulation of T cell proliferation
GO:0032689 IEA:Ensembl P negative regulation of interferon-gamma production
GO:0032696 IEA:Ensembl P negative regulation of interleukin-13 production
GO:0032713 IEA:Ensembl P negative regulation of interleukin-4 production
GO:0032714 IEA:Ensembl P negative regulation of interleukin-5 production
GO:0000122 IEA:Ensembl P negative regulation of transcription from RNA polymerase II promoter
GO:0050727 IEA:Ensembl P regulation of inflammatory response
GO:0043488 IEA:Ensembl P regulation of mRNA stability
GO:0034097 IEA:Ensembl P response to cytokine
GO:0042493 IEA:Ensembl P response to drug
GO:0071774 IEA:Ensembl P response to fibroblast growth factor
GO:0051384 IEA:Ensembl P response to glucocorticoid
GO:0032496 IEA:Ensembl P response to lipopolysaccharide
GO:0010193 IEA:Ensembl P response to ozone
GO:0034021 IEA:Ensembl P response to silicon dioxide
GO:0009410 IEA:Ensembl P response to xenobiotic stimulus
GO:0007165 NAS:ProtInc P signal transduction

Domain Information

InterPro Annotations

Accession Description
IPR016126 Secretoglobin
IPR000329 Uteroglobin

UniProt Annotations

Entry Information

Gene Name
secretoglobin, family 1A, member 1 (uteroglobin)
Protein Entry
UTER_HUMAN
UniProt ID
P11684
Species
Human

Comments

Comment Type Description
Function Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2.
Interaction P02751:FN1; NbExp=3; IntAct=EBI-7797649, EBI-1220319;
Similarity Belongs to the secretoglobin family.
Subcellular Location Secreted.
Subunit Homodimer; antiparallel disulfide-linked.
Tissue Specificity Clara cells (nonciliated cells of the surface epithelium of the pulmonary airways).

Identical and Related Proteins

Unique RefSeq proteins for LMP002699 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
4507809 RefSeq NP_003348 91 uteroglobin precursor

Identical Sequences to LMP002699 proteins

Reference Database Accession Length Protein Name
GI:4507809 DBBJ BAJ20526.1 91 secretoglobin, family 1A, member 1, partial [synthetic construct]
GI:4507809 GenBank ADA41310.1 91 Sequence 30 from patent US 7622260
GI:4507809 GenBank AGU04128.1 91 Sequence 19 from patent US 8476008
GI:4507809 GenBank AGY20574.1 91 Sequence 30 from patent US 8551700
GI:4507809 GenBank AHE01463.1 91 Sequence 57286 from patent US 8586006
GI:4507809 GenBank AIC49942.1 91 SCGB1A1, partial [synthetic construct]

Related Sequences to LMP002699 proteins

Reference Database Accession Length Protein Name
GI:4507809 GenBank AAP36520.1 92 Homo sapiens secretoglobin, family 1A, member 1 (uteroglobin), partial [synthetic construct]
GI:4507809 GenBank AAX29092.1 92 secretoglobin family 1A member 1, partial [synthetic construct]
GI:4507809 GenBank AAX29789.1 92 secretoglobin family 1A member 1, partial [synthetic construct]
GI:4507809 GenBank AAX36688.1 92 secretoglobin family 1A member 1, partial [synthetic construct]
GI:4507809 GenBank AAX36957.1 92 secretoglobin family 1A member 1, partial [synthetic construct]
GI:4507809 GenBank AAX42639.1 92 secretoglobin family 1A member 1, partial [synthetic construct]