Gene/Proteome Database (LMPD)

LMPD ID
LMP002655
Gene ID
12747
Species
Mus musculus (Mouse)
Gene Name
CDC-like kinase 1
Gene Symbol
Clk1
Synonyms
STY
Alternate Names
dual specificity protein kinase CLK1; protein kinase STY
Chromosome
1
Map Location
1 C1.3|1 29.09 cM
EC Number
2.7.12.1

Proteins

dual specificity protein kinase CLK1
Refseq ID NP_001036099
Protein GI 111038135
UniProt ID P22518
mRNA ID NM_001042634
Length 483
RefSeq Status VALIDATED
MRHSKRTYCPDWDERDWDYGTWRSSSSHKRKKRSHSSAREQKRCRYDHSKTTDSYYLESRSINEKAYHSRRYVDEYRNDYMGYEPGHPYGEPGSRYQMHSSKSSGRSGRSSYKSKHRSRHHTSQHHSHGKSHRRKRSRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKVGGRRVAVKIVKNVDRYCEAAQSEIQVLEHLNTTDPHSTFRCVQMLEWFEHRGHICIVFELLGLSTYDFIKENSFLPFRMDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVKSDYTEAYNPKMKRDERTIVNPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSREHLAMMERILGPLPKHMIQKTRKRRYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDAEHELLFDLIGKMLEYDPAKRITLKEALKHPFFYPLKKHT

Gene Information

Entrez Gene ID
12747
Gene Name
CDC-like kinase 1
Gene Symbol
Clk1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:Ensembl C cytoplasm
GO:0005634 IDA:MGI C nucleus
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0004674 IDA:MGI F protein serine/threonine kinase activity
GO:0004712 IEA:UniProtKB-EC F protein serine/threonine/tyrosine kinase activity
GO:0004713 IDA:MGI F protein tyrosine kinase activity
GO:0018105 IDA:MGI P peptidyl-serine phosphorylation
GO:0018107 IDA:MGI P peptidyl-threonine phosphorylation
GO:0018108 IDA:MGI P peptidyl-tyrosine phosphorylation
GO:0046777 IDA:MGI P protein autophosphorylation
GO:0043484 IEA:Ensembl P regulation of RNA splicing

KEGG Pathway Links

KEGG Pathway ID Description
ko05134 Legionellosis
mmu05134 Legionellosis

Domain Information

InterPro Annotations

Accession Description
IPR000719 Protein kinase domain
IPR017441 Protein kinase, ATP binding site
IPR011009 Protein kinase-like domain
IPR008271 Serine/threonine-protein kinase, active site
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain

UniProt Annotations

Entry Information

Gene Name
CDC-like kinase 1
Protein Entry
CLK1_MOUSE
UniProt ID
P22518
Species
Mouse

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=Long; IsoId=P22518-1; Sequence=Displayed; Name=Short; Synonyms=Clk1T; IsoId=P22518-2; Sequence=VSP_004854, VSP_004855; Note=Lacks the kinase domain.;
Catalytic Activity ATP + a protein = ADP + a phosphoprotein.
Enzyme Regulation Regulates splicing of its own pre-mRNA according to its kinase activity; increased expression of the catalytically active form influences splicing to generate the catalytically inactive splicing variant lacking the kinase domain. Leucettine L41 inhibits its kinase activity and affects the regulation of alternative splicing mediated by phosphorylation of SR proteins. {ECO:0000269|PubMed:21615147, ECO:0000269|PubMed:9315658}.
Function Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells and adenovirus E1A pre-mRNA. {ECO:0000269|PubMed:9307018, ECO:0000269|PubMed:9315658}.
Interaction Q5ZRQ0:lubX (xeno); NbExp=3; IntAct=EBI-6479117, EBI-6402540;
Ptm Autophosphorylates on all three types of residues. {ECO:0000269|PubMed:17242355, ECO:0000269|PubMed:9307018}.
Similarity Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily. {ECO:0000305}.
Similarity Contains 1 protein kinase domain. {ECO:0000255|PROSITE-ProRule:PRU00159}.
Subcellular Location Nucleus {ECO:0000269|PubMed:9307018}.
Subunit Interacts with PPIG and UBL5. {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP002655 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
111038135 RefSeq NP_001036099 483 dual specificity protein kinase CLK1

Identical Sequences to LMP002655 proteins

Reference Database Accession Length Protein Name
GI:111038135 DBBJ BAE22647.1 483 unnamed protein product [Mus musculus]
GI:111038135 GenBank ABK42178.1 483 Clk1 [synthetic construct]
GI:111038135 GenBank EDL00074.1 483 CDC-like kinase 1, isoform CRA_a [Mus musculus]
GI:111038135 GenBank AAI60357.1 483 CDC-like kinase 1 [synthetic construct]
GI:111038135 SwissProt P22518.2 483 RecName: Full=Dual specificity protein kinase CLK1; AltName: Full=CDC-like kinase 1; AltName: Full=Protein kinase STY [Mus musculus]

Related Sequences to LMP002655 proteins

Reference Database Accession Length Protein Name
GI:111038135 EMBL CAA40473.1 483 protein kinase [Mus musculus]
GI:111038135 GenBank AAA40151.1 483 serine threonine tyrosine kinase [Mus musculus]
GI:111038135 GenBank AAW05872.1 483 Sequence 20 from patent US 6797513
GI:111038135 GenBank EDL98996.1 483 CDC-like kinase 1, isoform CRA_b [Rattus norvegicus]
GI:111038135 RefSeq NP_001100383.2 483 dual specificity protein kinase CLK1 [Rattus norvegicus]
GI:111038135 RefSeq XP_006975118.1 483 PREDICTED: dual specificity protein kinase CLK1 [Peromyscus maniculatus bairdii]