Gene/Proteome Database (LMPD)

LMPD ID
LMP002588
Gene ID
1607
Species
Homo sapiens (Human)
Gene Name
diacylglycerol kinase, beta 90kDa
Gene Symbol
DGKB
Synonyms
DAGK2; DGK; DGK-BETA
Alternate Names
diacylglycerol kinase beta; DAG kinase beta; diglyceride kinase beta; 90 kDa diacylglycerol kinase
Chromosome
7
Map Location
7p21.2
EC Number
2.7.1.107
Summary
Diacylglycerol kinases (DGKs) are regulators of the intracellular concentration of the second messenger diacylglycerol (DAG) and thus play a key role in cellular processes. Nine mammalian isotypes have been identified, which are encoded by separate genes. Mammalian DGK isozymes contain a conserved catalytic (kinase) domain and a cysteine-rich domain (CRD). The protein encoded by this gene is a diacylglycerol kinase, beta isotype. Two alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for DGKB

Proteins

diacylglycerol kinase beta isoform 1
Refseq ID NP_004071
Protein GI 22027632
UniProt ID Q9Y6T7
mRNA ID NM_004080
Length 804
RefSeq Status REVIEWED
MTNQEKWAHLSPSEFSQLQKYAEYSTKKLKDVLEEFHGNGVLAKYNPEGKQDILNQTIDFEGFKLFMKTFLEAELPDDFTAHLFMSFSNKFPHSSPMVKSKPALLSGGLRMNKGAITPPRTTSPANTCSPEVIHLKDIVCYLSLLERGRPEDKLEFMFRLYDTDGNGFLDSSELENIISQMMHVAEYLEWDVTELNPILHEMMEEIDYDHDGTVSLEEWIQGGMTTIPLLVLLGLENNVKDDGQHVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSCIKTYVKSKRNTDVMHHYWVEGNCPTKCDKCHKTVKCYQGLTGLHCVWCQITLHNKCASHLKPECDCGPLKDHILPPTTICPVVLQTLPTSGVSVPEERQSTVKKEKSGSQQPNKVIDKNKMQRANSVTVDGQGLQVTPVPGTHPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSGNGPMPGLNFFRDVPDFRVLACGGDGTVGWVLDCIEKANVGKHPPVAILPLGTGNDLARCLRWGGGYEGENLMKILKDIENSTEIMLDRWKFEVIPNDKDEKGDPVPYSIINNYFSIGVDASIAHRFHIMREKHPEKFNSRMKNKFWYFEFGTSETFSATCKKLHESVEIECDGVQIDLINISLEGIAILNIPSMHGGSNLWGESKKRRSHRRIEKKGSDKRTTVTDAKELKFASQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCSCVVIRTSKSLPMQIDGEPWMQTPCTIKITHKNQAPMLMGPPPKTGLFCSLVKRTRNRSKE
diacylglycerol kinase beta isoform 2
Refseq ID NP_663733
Protein GI 22027634
UniProt ID Q9Y6T7
mRNA ID NM_145695
Length 773
RefSeq Status REVIEWED
MTNQEKWAHLSPSEFSQLQKYAEYSTKKLKDVLEEFHGNGVLAKYNPEGKQDILNQTIDFEGFKLFMKTFLEAELPDDFTAHLFMSFSNKFPHSSPMVKSKPALLSGGLRMNKGAITPPRTTSPANTCSPEVIHLKDIVCYLSLLERGRPEDKLEFMFRLYDTDGNGFLDSSELENIISQMMHVAEYLEWDVTELNPILHEMMEEIDYDHDGTVSLEEWIQGGMTTIPLLVLLGLENNVKDDGQHVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSCIKTYVKSKRNTDVMHHYWVEGNCPTKCDKCHKTVKCYQGLTGLHCVWCQITLHNKCASHLKPECDCGPLKDHILPPTTICPVVLQTLPTSGVSVPEERQSTVKKEKSGSQQPNKVIDKNKMQRANSVTVDGQGLQVTPVPGTHPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSGNGPMPGLNFFRDVPDFRVLACGGDGTVGWVLDCIEKANVGKHPPVAILPLGTGNDLARCLRWGGGYEGENLMKILKDIENSTEIMLDRWKFEVIPNDKDEKGDPVPYSIINNYFSIGVDASIAHRFHIMREKHPEKFNSRMKNKFWYFEFGTSETFSATCKKLHESVEIECDGVQIDLINISLEGIAILNIPSMHGGSNLWGESKKRRSHRRIEKKGSDKRTTVTDAKELKFASQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCSCVVIRTSKSLPMQIDGEPWMQTPCTVSTE

Gene Information

Entrez Gene ID
1607
Gene Name
diacylglycerol kinase, beta 90kDa
Gene Symbol
DGKB
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0005886 TAS:Reactome C plasma membrane
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0003951 IEA:InterPro F NAD+ kinase activity
GO:0005509 IEA:InterPro F calcium ion binding
GO:0004143 IEA:UniProtKB-EC F diacylglycerol kinase activity
GO:0007596 TAS:Reactome P blood coagulation
GO:0035556 IEA:InterPro P intracellular signal transduction
GO:0030168 TAS:Reactome P platelet activation
GO:0007205 IEA:InterPro P protein kinase C-activating G-protein coupled receptor signaling pathway

KEGG Pathway Links

KEGG Pathway ID Description
hsa00561 Glycerolipid metabolism
hsa00564 Glycerophospholipid metabolism
hsa01100 Metabolic pathways

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_19184 GPCR downstream signaling

Domain Information

InterPro Annotations

Accession Description
IPR016064 ATP-NAD kinase-like domain
IPR029477 Diacylglycerol kinase type I, N-terminal
IPR000756 Diacylglycerol kinase, accessory domain
IPR001206 Diacylglycerol kinase, catalytic domain
IPR018247 EF-Hand 1, calcium-binding site
IPR002048 EF-hand domain
IPR011992 EF-hand domain pair
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain

UniProt Annotations

Entry Information

Gene Name
diacylglycerol kinase, beta 90kDa
Protein Entry
DGKB_HUMAN
UniProt ID
Q9Y6T7
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Y6T7-1; Sequence=Displayed; Name=2; IsoId=Q9Y6T7-2; Sequence=VSP_021898, VSP_021899; Note=No experimental confirmation available.;
Catalytic Activity ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2- diacyl-sn-glycerol 3-phosphate.
Enzyme Regulation Stimulated by phosphatidylserine.
Function Exhibits high phosphorylation activity for long-chain diacylglycerols.
Sequence Caution Sequence=AAS07533.1; Type=Erroneous gene model prediction; Evidence= ;
Similarity Belongs to the eukaryotic diacylglycerol kinase family.
Similarity Contains 1 DAGKc domain. {ECO
Similarity Contains 2 EF-hand domains. {ECO
Similarity Contains 2 phorbol-ester/DAG-type zinc fingers.
Subcellular Location Cytoplasm .

Identical and Related Proteins

Unique RefSeq proteins for LMP002588 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
22027632 RefSeq NP_004071 804 diacylglycerol kinase beta isoform 1
22027634 RefSeq NP_663733 773 diacylglycerol kinase beta isoform 2

Identical Sequences to LMP002588 proteins

Reference Database Accession Length Protein Name
GI:22027634 GenBank EAL24293.1 773 diacylglycerol kinase, beta 90kDa [Homo sapiens]
GI:22027634 GenBank AAI05006.1 773 Diacylglycerol kinase, beta 90kDa [Homo sapiens]
GI:22027634 GenBank EAW93663.1 773 diacylglycerol kinase, beta 90kDa, isoform CRA_a [Homo sapiens]
GI:22027632 GenBank EAW93664.1 804 diacylglycerol kinase, beta 90kDa, isoform CRA_b [Homo sapiens]
GI:22027634 GenBank ACN05698.1 773 Sequence 29 from patent US 7485468
GI:22027632 GenBank ACN05699.1 804 Sequence 30 from patent US 7485468
GI:22027634 GenBank AFO01442.1 773 Sequence 29 from patent US 8097408
GI:22027632 GenBank AFO01443.1 804 Sequence 30 from patent US 8097408
GI:22027632 GenBank AHE00563.1 804 Sequence 53520 from patent US 8586006
GI:22027632 GenBank AHE20043.1 804 Sequence 56 from patent US 8574857
GI:22027634 GenBank AHE20044.1 773 Sequence 57 from patent US 8574857
GI:22027632 RefSeq XP_005249685.1 804 PREDICTED: diacylglycerol kinase beta isoform X1 [Homo sapiens]

Related Sequences to LMP002588 proteins

Reference Database Accession Length Protein Name
GI:22027634 GenBank EAL24292.1 804 diacylglycerol kinase, beta 90kDa [Homo sapiens]
GI:22027634 GenBank EAW93664.1 804 diacylglycerol kinase, beta 90kDa, isoform CRA_b [Homo sapiens]
GI:22027634 GenBank AHE00563.1 804 Sequence 53520 from patent US 8586006
GI:22027634 RefSeq NP_004071.1 804 diacylglycerol kinase beta isoform 1 [Homo sapiens]
GI:22027632 RefSeq XP_001148960.1 804 PREDICTED: diacylglycerol kinase beta isoform X1 [Pan troglodytes]
GI:22027632 RefSeq XP_003252639.1 804 PREDICTED: diacylglycerol kinase beta [Nomascus leucogenys]
GI:22027632 RefSeq XP_003825053.1 804 PREDICTED: diacylglycerol kinase beta isoform X1 [Pan paniscus]
GI:22027634 RefSeq XP_005249685.1 804 PREDICTED: diacylglycerol kinase beta isoform X1 [Homo sapiens]
GI:22027632 RefSeq XP_009450952.1 804 PREDICTED: diacylglycerol kinase beta isoform X1 [Pan troglodytes]
GI:22027632 RefSeq XP_009450953.1 804 PREDICTED: diacylglycerol kinase beta isoform X1 [Pan troglodytes]
GI:22027632 RefSeq XP_009450954.1 804 PREDICTED: diacylglycerol kinase beta isoform X1 [Pan troglodytes]
GI:22027634 SwissProt Q9Y6T7.2 804 RecName: Full=Diacylglycerol kinase beta; Short=DAG kinase beta; AltName: Full=90 kDa diacylglycerol kinase; AltName: Full=Diglyceride kinase beta; Short=DGK-beta [Homo sapiens]