Gene/Proteome Database (LMPD)

LMPD ID
LMP002453
Gene ID
104418
Species
Mus musculus (Mouse)
Gene Name
diacylglycerol kinase zeta
Gene Symbol
Dgkz
Synonyms
E130307B02Rik; ENSMUSG00000075035; F730209L11Rik; mDGK[z]
Chromosome
2
Map Location
2 E1|2

Proteins

diacylglycerol kinase zeta isoform 1
Refseq ID NP_001160069
Protein GI 262205333
UniProt ID A2AHK0
mRNA ID NM_001166597
Length 1123
RefSeq Status VALIDATED
METFFRKHFQRKARGPGERQRRSSGVGLPTGKARRRSPAGQASSSLAQRRRSSAQLQGCFPSCGVGTRGASRRRSSTAPPTCNPRFMVDVVPTLQPVTVGAQLLGAPLLLAGLTSMKEEEEEEGVQEGNETAEATSDARPGTRTTPFSHQGTWPLLPMPRCLRRASSHLLPADVECGHTLWGLHGHYRRLSQRWPSGQHPGLGGRSPRASGAAACPMIPARVRPLSRRRQVALRRKSAGPQPWSTLLMKAITKSGLQHLAPPPPTPGAPCGESEEQIQSTVDWSESAVYGEHIWFETNVSGDFCYVGEQHCVAKMLPKSAPRKKCAACKIVVHTQCIKQLEKINFRCKPSFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWCKQAYHSKVSCFMMQQIEEPCSLGVHAAVVIPPTWILRARRPQNTLKASKKKKRASFKRRSSKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQGGPREALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLARTLNWGGGYTDEPVSKILSHVEEGNVVQLDRWDLRAEPNPEAGPEERDDGATDRLPLDVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIRVVCDGMDLTPKIQDLKPQCIVFLNIPRYCAGTMPWGHPGEHHDFEPQRHDDGYLEVIGFTMTSLAALQVGGHGERLTQCREVLLTTAKAIPVQVDGEPCKLSASRIRIALRNQATMVQKAKRRSTAPLHSDQQPVPEQLRIQVSRVSMHDYEALHYDKEQLKEASVPLGTVVVPGDSDLELCRAHIERLQREPDGAGAKSPMCHQLSSKWCFLDATTASRFYRIDRAQEHLNYVTEIAQDEIYILDPELLGASARPDLPTPTSPLPASPCSPTPGSMQGDTALPQGEELIEAAKRNDCCKLQELHRAGGDLMHRDQKSRTLLHHAVSTGSKEVVRYLLDHAPPEILDAVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDLQGDTPRQRAEKAQDTELAAYLENRQHYQMIQREDQETAV
diacylglycerol kinase zeta isoform 2
Refseq ID NP_612179
Protein GI 262205328
UniProt ID Q80UP3
mRNA ID NM_138306
Length 929
RefSeq Status VALIDATED
MEPRDPSPEGRSSDSESASASSSGSERDAGPEPDKAPRRLTKRRFPGLRLFGHRKAITKSGLQHLAPPPPTPGAPCGESEEQIQSTVDWSESAVYGEHIWFETNVSGDFCYVGEQHCVAKMLPKSAPRKKCAACKIVVHTQCIKQLEKINFRCKPSFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWCKQAYHSKVSCFMMQQIEEPCSLGVHAAVVIPPTWILRARRPQNTLKASKKKKRASFKRRSSKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQGGPREALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLARTLNWGGGYTDEPVSKILSHVEEGNVVQLDRWDLRAEPNPEAGPEERDDGATDRLPLDVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIRVVCDGMDLTPKIQDLKPQCIVFLNIPRYCAGTMPWGHPGEHHDFEPQRHDDGYLEVIGFTMTSLAALQVGGHGERLTQCREVLLTTAKAIPVQVDGEPCKLSASRIRIALRNQATMVQKAKRRSTAPLHSDQQPVPEQLRIQVSRVSMHDYEALHYDKEQLKEASVPLGTVVVPGDSDLELCRAHIERLQREPDGAGAKSPMCHQLSSKWCFLDATTASRFYRIDRAQEHLNYVTEIAQDEIYILDPELLGASARPDLPTPTSPLPASPCSPTPGSMQGDTALPQGEELIEAAKRNDCCKLQELHRAGGDLMHRDQKSRTLLHHAVSTGSKEVVRYLLDHAPPEILDAVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDLQGDTPRQRAEKAQDTELAAYLENRQHYQMIQREDQETAV

Gene Information

Entrez Gene ID
104418
Gene Name
diacylglycerol kinase zeta
Gene Symbol
Dgkz
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0030027 IEA:Ensembl C lamellipodium
GO:0005634 IEA:Ensembl C nucleus
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0003951 IEA:InterPro F NAD+ kinase activity
GO:0004143 IEA:UniProtKB-EC F diacylglycerol kinase activity
GO:0004857 IDA:MGI F enzyme inhibitor activity
GO:0001727 IEA:Ensembl F lipid kinase activity
GO:0035556 IEA:InterPro P intracellular signal transduction
GO:0031571 IEA:Ensembl P mitotic G1 DNA damage checkpoint
GO:0046580 IMP:MGI P negative regulation of Ras protein signal transduction
GO:0043086 IDA:GOC P negative regulation of catalytic activity
GO:0045930 IEA:Ensembl P negative regulation of mitotic cell cycle
GO:0007205 IEA:InterPro P protein kinase C-activating G-protein coupled receptor signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR016064 ATP-NAD kinase-like domain
IPR002110 Ankyrin repeat
IPR020683 Ankyrin repeat-containing domain
IPR000756 Diacylglycerol kinase, accessory domain
IPR001206 Diacylglycerol kinase, catalytic domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain

UniProt Annotations

Entry Information

Gene Name
diacylglycerol kinase zeta
Protein Entry
DGKZ_MOUSE
UniProt ID
Q80UP3
Species
Mouse

Comments

Comment Type Description
Catalytic Activity ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2- diacyl-sn-glycerol 3-phosphate.
Similarity Belongs to the eukaryotic diacylglycerol kinase family.
Similarity Contains 1 DAGKc domain.
Similarity Contains 2 ANK repeats.

Identical and Related Proteins

Unique RefSeq proteins for LMP002453 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
262205333 RefSeq NP_001160069 1123 diacylglycerol kinase zeta isoform 1
262205328 RefSeq NP_612179 929 diacylglycerol kinase zeta isoform 2

Identical Sequences to LMP002453 proteins

Reference Database Accession Length Protein Name
GI:262205333 GenBank EDL27585.1 1123 diacylglycerol kinase zeta, isoform CRA_b [Mus musculus]
GI:262205328 SwissProt Q80UP3.2 929 RecName: Full=Diacylglycerol kinase zeta; Short=DAG kinase zeta; AltName: Full=Diglyceride kinase zeta; Short=DGK-zeta [Mus musculus]

Related Sequences to LMP002453 proteins

Reference Database Accession Length Protein Name
GI:262205328 DBBJ BAA18942.1 929 diacylglycerol kinase [Rattus norvegicus]
GI:262205328 GenBank AAH49228.1 929 Diacylglycerol kinase zeta [Mus musculus]
GI:262205328 GenBank EDL27583.1 931 diacylglycerol kinase zeta, isoform CRA_a, partial [Mus musculus]
GI:262205328 GenBank EDL27584.1 931 diacylglycerol kinase zeta, isoform CRA_a, partial [Mus musculus]
GI:262205333 GenBank EDL79553.1 1121 diacylglycerol kinase zeta, isoform CRA_b [Rattus norvegicus]
GI:262205333 RefSeq XP_006234656.1 1121 PREDICTED: diacylglycerol kinase zeta isoform X1 [Rattus norvegicus]
GI:262205333 RefSeq XP_006498600.1 1137 PREDICTED: diacylglycerol kinase zeta isoform X1 [Mus musculus]
GI:262205333 RefSeq XP_006498601.1 1136 PREDICTED: diacylglycerol kinase zeta isoform X2 [Mus musculus]
GI:262205328 RefSeq XP_006498605.1 943 PREDICTED: diacylglycerol kinase zeta isoform X6 [Mus musculus]
GI:262205333 RefSeq XP_006984399.1 1126 PREDICTED: diacylglycerol kinase zeta isoform X2 [Peromyscus maniculatus bairdii]
GI:262205333 RefSeq XP_008760259.1 1121 PREDICTED: diacylglycerol kinase zeta isoform X1 [Rattus norvegicus]
GI:262205328 SwissProt O08560.1 929 RecName: Full=Diacylglycerol kinase zeta; Short=DAG kinase zeta; AltName: Full=104 kDa diacylglycerol kinase; AltName: Full=DGK-IV; AltName: Full=Diglyceride kinase zeta; Short=DGK-zeta [Rattus norvegicus]