Gene/Proteome Database (LMPD)

LMPD ID
LMP002440
Gene ID
13075
Species
Mus musculus (Mouse)
Gene Name
cytochrome P450, family 19, subfamily a, polypeptide 1
Gene Symbol
Cyp19a1
Synonyms
Ar; ArKO; Cyp19; Int-5; Int5; p450arom
Alternate Names
aromatase; CYPXIX; estrogen synthase; cytochrome P-450AROM; cytochrome P450 19A1; cytochrome P450, 19, aromatase
Chromosome
9
Map Location
9 A5.3|9 29.49 cM
EC Number
1.14.14.14

Proteins

aromatase
Refseq ID NP_031836
Protein GI 6681099
UniProt ID P28649
mRNA ID NM_007810
Length 503
RefSeq Status PROVISIONAL
MFLEMLNPMQYNVTIMVPETVTVSAMPLLLIMGLLLLIWNCESSSSIPGPGYCLGIGPLISHGRFLWMGIGSACNYYNKMYGEFMRVWISGEETLIISKSSSMFHVMKHSHYISRFGSKRGLQCIGMHENGIIFNNNPSLWRTIRPFFMKALTGPGLVRMVEVCVESIKQHLDRLGEVTDTSGYVDVLTLMRHIMLDTSNMLFLGIPLDESAIVKKIQGYFNAWQALLIKPNIFFKISWLYRKYERSVKDLKDEIAVLVEKKRHKVSTAEKLEDCMDFATDLIFAERRGDLTKENVNQCILEMLIAAPDTMSVTLYFMLLLVAEYPEVEAAILKEIHTVVGDRDIKIEDIQNLKVVENFINESMRYQPVVDLVMRRALEDDVIDGYPVKKGTNIILNIGRMHRLEYFPKPNEFTLENFEKNVPYRYFQPFGFGPRGCAGKYIAMVMMKVVLVTLLRRFQVKTLQKRCIENIPKKNDLSLHPNEDRHLVEIIFSPRNSDKYLQQ

Gene Information

Entrez Gene ID
13075
Gene Name
cytochrome P450, family 19, subfamily a, polypeptide 1
Gene Symbol
Cyp19a1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:Ensembl C endoplasmic reticulum
GO:0016020 IEA:UniProtKB-KW C membrane
GO:0070330 ISS:UniProtKB F aromatase activity
GO:0020037 ISS:UniProtKB F heme binding
GO:0005506 IEA:InterPro F iron ion binding
GO:0016712 IDA:MGI F oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
GO:0008209 IMP:MGI P androgen metabolic process
GO:0060736 IMP:MGI P prostate gland growth

KEGG Pathway Links

KEGG Pathway ID Description
mmu04913 Ovarian steroidogenesis
mmu00140 Steroid hormone biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR001128 Cytochrome P450
IPR002401 Cytochrome P450, E-class, group I
IPR017972 Cytochrome P450, conserved site

UniProt Annotations

Entry Information

Gene Name
cytochrome P450, family 19, subfamily a, polypeptide 1
Protein Entry
CP19A_MOUSE
UniProt ID
P28649
Species
Mouse

Comments

Comment Type Description
Catalytic Activity Androst-4-ene-3,17-dione + 3 O(2) + 3 reduced flavoproteins = estrone + formate + 4 H(2)O + 3 oxidized flavoproteins.
Catalytic Activity Testosterone + 3 O(2) + 3 reduced flavoproteins = 17-beta-estradiol + formate + 4 H(2)O + 3 oxidized flavoproteins.
Cofactor Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
Function Catalyzes the formation of aromatic C18 estrogens from C19 androgens.
Similarity Belongs to the cytochrome P450 family. {ECO:0000305}.
Subcellular Location Membrane; Peripheral membrane protein.

Identical and Related Proteins

Unique RefSeq proteins for LMP002440 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6681099 RefSeq NP_031836 503 aromatase

Identical Sequences to LMP002440 proteins

Reference Database Accession Length Protein Name
GI:6681099 DBBJ BAE25342.1 503 unnamed protein product [Mus musculus]
GI:6681099 GenBank AAI04490.1 503 Cytochrome P450, family 19, subfamily a, polypeptide 1 [Mus musculus]
GI:6681099 GenBank EDL25809.1 503 cytochrome P450, family 19, subfamily a, polypeptide 1 [Mus musculus]
GI:6681099 RefSeq XP_006510868.1 503 PREDICTED: cytochrome P450 19A1 isoform X1 [Mus musculus]
GI:6681099 RefSeq XP_006510869.1 503 PREDICTED: cytochrome P450 19A1 isoform X2 [Mus musculus]
GI:6681099 RefSeq XP_006510870.1 503 PREDICTED: cytochrome P450 19A1 isoform X3 [Mus musculus]

Related Sequences to LMP002440 proteins

Reference Database Accession Length Protein Name
GI:6681099 GenBank EDL95528.1 503 cytochrome P450, family 19, subfamily a, polypeptide 1, isoform CRA_a [Rattus norvegicus]
GI:6681099 GenBank ERE76914.1 503 cytochrome P450 19A1-like protein [Cricetulus griseus]
GI:6681099 RefSeq NP_058781.2 503 aromatase [Rattus norvegicus]
GI:6681099 RefSeq XP_003508831.1 503 PREDICTED: aromatase [Cricetulus griseus]
GI:6681099 RefSeq XP_006971648.1 504 PREDICTED: aromatase-like [Peromyscus maniculatus bairdii]
GI:6681099 RefSeq XP_007616047.1 503 PREDICTED: aromatase [Cricetulus griseus]