Gene/Proteome Database (LMPD)

LMPD ID
LMP002390
Gene ID
20250
Species
Mus musculus (Mouse)
Gene Name
stearoyl-Coenzyme A desaturase 2
Gene Symbol
Scd2
Synonyms
Scd-2; swty
Alternate Names
acyl-CoA desaturase 2; delta-9 desaturase 2; delta(9)-desaturase 2; fatty acid desaturase 2; stearoyl-CoA desaturase 2; Acyl-CoA desaturase 2 (Stearoyl-CoA desaturase 2) (Fatty acid desaturase 2) (Delta(9)-desaturase 2)
Chromosome
19
Map Location
19 C3|19 37.98 cM
EC Number
1.14.19.1

Proteins

acyl-CoA desaturase 2
Refseq ID NP_033154
Protein GI 188219606
UniProt ID P13011
mRNA ID NM_009128
Length 358
RefSeq Status VALIDATED
MPAHILQEISGAYSATTTITAPPSGGQQNGGEKFEKSSHHWGADVRPELKDDLYDPTYQDDEGPPPKLEYVWRNIILMALLHLGALYGITLVPSCKLYTCLFAYLYYVISALGITAGAHRLWSHRTYKARLPLRLFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSHVGWLLVRKHPAVKEKGGKLDMSDLKAEKLVMFQRRYYKPGLLLMCFVLPTLVPWYCWGETFVNSLCVSTFLRYAVVLNATWLVNSAAHLYGYRPYDKNISSRENILVSMGAVGEGFHNYHHAFPYDYSASEYRWHINFTTFFIDCMALLGLAYDRKRVSRAAVLARIKRTGDGSCKSG

Gene Information

Entrez Gene ID
20250
Gene Name
stearoyl-Coenzyme A desaturase 2
Gene Symbol
Scd2
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IDA:MGI C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005506 IEA:InterPro F iron ion binding
GO:0004768 IEA:UniProtKB-EC F stearoyl-CoA 9-desaturase activity
GO:0006633 IEA:UniProtKB-KW P fatty acid biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu04152 AMPK signaling pathway
mmu01040 Biosynthesis of unsaturated fatty acids
mmu03320 PPAR signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR005804 Fatty acid desaturase, type 1
IPR001522 Fatty acid desaturase, type 1, C-terminal
IPR015876 Fatty acid desaturase, type 1, core

UniProt Annotations

Entry Information

Gene Name
stearoyl-Coenzyme A desaturase 2
Protein Entry
ACOD2_MOUSE
UniProt ID
P13011
Species
Mouse

Comments

Comment Type Description
Catalytic Activity Stearoyl-CoA + 2 ferrocytochrome b5 + O(2) + 2 H(+) = oleoyl-CoA + 2 ferricytochrome b5 + 2 H(2)O.
Cofactor Name=Fe cation; Xref=ChEBI:CHEBI:24875;
Domain The histidine box domains may contain the active site and/or be involved in metal ion binding.
Function Terminal component of the liver microsomal stearyl-CoA desaturase system, that utilizes O(2) and electrons from reduced cytochrome b5 to catalyze the insertion of a double bond into a spectrum of fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA.
Similarity Belongs to the fatty acid desaturase family. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Identical and Related Proteins

Unique RefSeq proteins for LMP002390 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
188219606 RefSeq NP_033154 358 acyl-CoA desaturase 2

Identical Sequences to LMP002390 proteins

Reference Database Accession Length Protein Name
GI:188219606 DBBJ BAC39066.1 358 unnamed protein product [Mus musculus]
GI:188219606 DBBJ BAE27893.1 358 unnamed protein product [Mus musculus]
GI:188219606 GenBank AAH40384.1 358 Stearoyl-Coenzyme A desaturase 2 [Mus musculus]
GI:188219606 GenBank EDL41928.1 358 mCG10078, isoform CRA_b [Mus musculus]
GI:188219606 SwissProt P13011.2 358 RecName: Full=Acyl-CoA desaturase 2; AltName: Full=Delta(9)-desaturase 2; Short=Delta-9 desaturase 2; AltName: Full=Fatty acid desaturase 2; AltName: Full=Stearoyl-CoA desaturase 2 [Mus musculus]

Related Sequences to LMP002390 proteins

Reference Database Accession Length Protein Name
GI:188219606 DBBJ BAA92436.1 358 stearoyl-CoA desaturase 2 [Rattus norvegicus]
GI:188219606 GenBank AAA40094.1 358 stearoyl-CoA desaturase 2 [Mus musculus]
GI:188219606 GenBank ABU29330.1 358 Sequence 4 from patent US 7232662
GI:188219606 GenBank ACK08922.1 358 Sequence 4 from patent US 7435559
GI:188219606 GenBank AED45063.1 376 Sequence 9 from patent US 7892730
GI:188219606 RefSeq NP_114029.1 358 acyl-CoA desaturase 2 [Rattus norvegicus]