Gene/Proteome Database (LMPD)

LMPD ID
LMP002304
Gene ID
15356
Species
Mus musculus (Mouse)
Gene Name
3-hydroxy-3-methylglutaryl-Coenzyme A lyase
Gene Symbol
Hmgcl
Synonyms
AW476067; HL
Alternate Names
hydroxymethylglutaryl-CoA lyase, mitochondrial; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase
Chromosome
4
Map Location
4 D3|4 68.14 cM
EC Number
4.1.3.4

Proteins

hydroxymethylglutaryl-CoA lyase, mitochondrial precursor
Refseq ID NP_032280
Protein GI 171543858
UniProt ID P38060
mRNA ID NM_008254
Length 325
RefSeq Status VALIDATED
MASVRKAFPRRLVGLTSLRAVSTSSMGTLPKQVKIVEVGPRDGLQNEKSIVPTPVKIRLIDMLSEAGLPVIEATSFVSPKWVPQMADHSDVLKGIQKFPGINYPVLTPNMKGFEEAVAAGAKEVSVFGAVSELFTRKNANCSIEESFQRFAGVMQAAQAASISVRGYVSCALGCPYEGKVSPAKVAEVAKKLYSMGCYEISLGDTIGVGTPGLMKDMLTAVMHEVPVTALAVHCHDTYGQALANTLVALQMGVSVVDSSVAGLGGCPYAKGASGNLATEDLVYMLNGLGIHTGVNLQKLLEAGDFICQALNRKTSSKVAQATCKL
transit_peptide: 1..27 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (By similarity); propagated from UniProtKB/Swiss-Prot (P38060.2) calculated_mol_wt: 2879 peptide sequence: MASVRKAFPRRLVGLTSLRAVSTSSMG mat_peptide: 28..325 product: Hydroxymethylglutaryl-CoA lyase, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P38060.2) calculated_mol_wt: 31378 peptide sequence: TLPKQVKIVEVGPRDGLQNEKSIVPTPVKIRLIDMLSEAGLPVIEATSFVSPKWVPQMADHSDVLKGIQKFPGINYPVLTPNMKGFEEAVAAGAKEVSVFGAVSELFTRKNANCSIEESFQRFAGVMQAAQAASISVRGYVSCALGCPYEGKVSPAKVAEVAKKLYSMGCYEISLGDTIGVGTPGLMKDMLTAVMHEVPVTALAVHCHDTYGQALANTLVALQMGVSVVDSSVAGLGGCPYAKGASGNLATEDLVYMLNGLGIHTGVNLQKLLEAGDFICQALNRKTSSKVAQATCKL

Gene Information

Entrez Gene ID
15356
Gene Name
3-hydroxy-3-methylglutaryl-Coenzyme A lyase
Gene Symbol
Hmgcl
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005743 IDA:MGI C mitochondrial inner membrane
GO:0005739 IDA:MGI C mitochondrion
GO:0005777 IEA:UniProtKB-KW C peroxisome
GO:0031406 IEA:Ensembl F carboxylic acid binding
GO:0000062 IEA:Ensembl F fatty-acyl-CoA binding
GO:0004419 ISS:UniProtKB F hydroxymethylglutaryl-CoA lyase activity
GO:0000287 IEA:Ensembl F magnesium ion binding
GO:0030145 IEA:Ensembl F manganese ion binding
GO:0046872 ISS:UniProtKB F metal ion binding
GO:0006637 IEA:Ensembl P acyl-CoA metabolic process
GO:0046951 ISS:UniProtKB P ketone body biosynthetic process
GO:0001889 IEA:Ensembl P liver development
GO:0007005 IMP:MGI P mitochondrion organization
GO:0051262 IEA:Ensembl P protein tetramerization
GO:0070542 IEA:Ensembl P response to fatty acid
GO:0007584 IEA:Ensembl P response to nutrient
GO:0042594 IEA:Ensembl P response to starvation

KEGG Pathway Links

KEGG Pathway ID Description
mmu04146 Peroxisome

Domain Information

InterPro Annotations

Accession Description
IPR013785 Aldolase-type TIM barrel
IPR000138 Hydroxymethylglutaryl-CoA lyase, active site
IPR000891 Pyruvate carboxyltransferase

UniProt Annotations

Entry Information

Gene Name
3-hydroxy-3-methylglutaryl-Coenzyme A lyase
Protein Entry
HMGCL_MOUSE
UniProt ID
P38060
Species
Mouse

Comments

Comment Type Description
Catalytic Activity (S)-3-hydroxy-3-methylglutaryl-CoA = acetyl- CoA + acetoacetate. {ECO:0000255|PROSITE-ProRule:PRU10115}.
Function Key enzyme in ketogenesis (ketone body formation). Terminal step in leucine catabolism. Ketone bodies (beta- hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism (By similarity). {ECO:0000250}.
Pathway Metabolic intermediate metabolism; (S)-3-hydroxy-3- methylglutaryl-CoA degradation; acetoacetate from (S)-3-hydroxy-3- methylglutaryl-CoA: step 1/1.
Similarity Belongs to the HMG-CoA lyase family. {ECO:0000305}.
Subcellular Location Mitochondrion matrix {ECO:0000269|PubMed:7527399}. Peroxisome {ECO:0000269|PubMed:7527399}. Note=Unprocessed form is peroxisomal.
Subunit Homodimer; disulfide-linked. Can also form homotetramers. {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP002304 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
171543858 RefSeq NP_032280 325 hydroxymethylglutaryl-CoA lyase, mitochondrial precursor

Identical Sequences to LMP002304 proteins

Reference Database Accession Length Protein Name
GI:171543858 DBBJ BAE32329.1 325 unnamed protein product [Mus musculus]
GI:171543858 DBBJ BAE20956.1 325 unnamed protein product [Mus musculus]
GI:171543858 DBBJ BAE26328.1 325 unnamed protein product [Mus musculus]
GI:171543858 GenBank AAH25440.1 325 Hmgcl protein [Mus musculus]
GI:171543858 GenBank EDL29963.1 325 3-hydroxy-3-methylglutaryl-Coenzyme A lyase [Mus musculus]
GI:171543858 SwissProt P38060.2 325 RecName: Full=Hydroxymethylglutaryl-CoA lyase, mitochondrial; Short=HL; Short=HMG-CoA lyase; AltName: Full=3-hydroxy-3-methylglutarate-CoA lyase; Flags: Precursor [Mus musculus]

Related Sequences to LMP002304 proteins

Reference Database Accession Length Protein Name
GI:171543858 GenBank AAB03107.1 325 3-hydroxy-3-methylglutaryl-CoA lyase [Mus musculus]
GI:171543858 GenBank AEQ84587.1 325 Sequence 81 from patent US 8039587
GI:171543858 GenBank AEU53450.1 325 Sequence 81 from patent US 8062891
GI:171543858 GenBank AGU32394.1 325 Sequence 81 from patent US 8507277
GI:171543858 GenBank AGX48298.1 325 Sequence 81 from patent US 8541550
GI:171543858 PIR - 325 3-Hydroxy-3-methylglutaryl coenzyme A lyase - mouse [Mus sp.]