Gene/Proteome Database (LMPD)

LMPD ID
LMP002220
Gene ID
70059
Species
Mus musculus (Mouse)
Gene Name
degenerative spermatocyte homolog 2 (Drosophila), lipid desaturase
Gene Symbol
Degs2
Synonyms
2210008A03Rik; AI852933; DES2
Chromosome
12
Map Location
12 F1|12

Proteins

sphingolipid delta(4)-desaturase/C4-hydroxylase DES2 isoform 1
Refseq ID NP_081575
Protein GI 27754029
UniProt ID Q8R2F2
mRNA ID NM_027299
Length 323
RefSeq Status VALIDATED
MGNSAARSDFEWVYSDQPHTQRRKEMLAKYPAIKALMRPDPHIKWTVSGMVLVQVLACWLVRGLSWRWLLFWAYAFGGCINHSLTLAIHDISHNTAFGTSCVSRNRWFAIFANLPIGLPYATSFKKYHVDHHRYLGGDGLDVDIPTNFEGWFFCTPARKLLWLVLQPFFYSLRPLCVNPKVVTRMEILNALVQLAFDVTIFALWGIKPIVYLLGSSLLGLGLHPISGHFVAEHYMFLKGHETYSYYGPLNWITFNVGYHMEHHDFPSIPGYYLPLVRKIAPEYYDHLPQHHSWVKVLWDFVFEDSMGPYSRVKRKCKLAKDHL
sphingolipid delta(4)-desaturase/C4-hydroxylase DES2 isoform 2
Refseq ID NP_001164473
Protein GI 283483988
UniProt ID Q8R2F2
mRNA ID NM_001171002
Length 286
RefSeq Status VALIDATED
MGNSAARSDFEWVYSDQPHTQRRKEMLAKYPAIKALMRPDPHIKWTVSGMVLVQVLACWLVRGLSWRWLLFWAYAFGGCINHSLTLAIHDISHNTAFGTSCVSRNRWFAIFANLPIGLPYATSFKKYHVDHHRYLGGDGLDVDIPTNFEGWFFCTPARKLLWLVLQPFFYSLRPLCVNPKVVTRMEILNALVQLAFDVTIFALWGIKPIVYLLGSSLLGLGLHPISGHFVAEHYMFLKGHETYSYYGPLNWITFNVGYHMEHHDFPSIPGYYLPLDDWNPVRRDVL

Gene Information

Entrez Gene ID
70059
Gene Name
degenerative spermatocyte homolog 2 (Drosophila), lipid desaturase
Gene Symbol
Degs2
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0042284 IGI:MGI F sphingolipid delta-4 desaturase activity
GO:0000170 IDA:MGI F sphingosine hydroxylase activity
GO:0046513 IDA:MGI P ceramide biosynthetic process
GO:0006667 IDA:MGI P sphinganine metabolic process
GO:0030148 IGI:MGI P sphingolipid biosynthetic process

Domain Information

InterPro Annotations

Accession Description
IPR005804 Fatty acid desaturase, type 1
IPR011388 Sphingolipid delta4-desaturase
IPR013866 Sphingolipid delta4-desaturase, N-terminal

UniProt Annotations

Entry Information

Gene Name
degenerative spermatocyte homolog 2 (Drosophila), lipid desaturase
Protein Entry
Q8R2F2_MOUSE
UniProt ID
Q8R2F2
Species
Mouse

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=Q8R2F2-1; Sequence=Displayed; Name=2 ; IsoId=Q8R2F2-2; Sequence=VSP_052629; Note=No experimental confirmation available. ;
Biophysicochemical Properties pH dependence: Optimum pH is 7.0-8.0. ;
Function Bifunctional enzyme which acts as both a sphingolipid delta(4)-desaturase and a sphingolipid C4-hydroxylase. {ECO:0000269|PubMed:11937514, ECO:0000269|PubMed:14731113, ECO:0000269|PubMed:16571104}.
Pathway Membrane lipid metabolism; sphingolipid biosynthesis.
Similarity Belongs to the fatty acid desaturase family. DEGS subfamily.
Subcellular Location Endoplasmic reticulum membrane ; Multi-pass membrane protein .
Tissue Specificity Highly expressed in intestinal crypt cells and adjacent epithelial cells (at protein level).

Identical and Related Proteins

Unique RefSeq proteins for LMP002220 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
27754029 RefSeq NP_081575 323 sphingolipid delta(4)-desaturase/C4-hydroxylase DES2 isoform 1
283483988 RefSeq NP_001164473 286 sphingolipid delta(4)-desaturase/C4-hydroxylase DES2 isoform 2

Identical Sequences to LMP002220 proteins

Reference Database Accession Length Protein Name
GI:27754029 GenBank AAM12533.1 323 sphingolipid delta 4 desaturase/C-4 hydroxylase protein DES2 [Mus musculus]
GI:27754029 GenBank AAH16427.2 323 Degenerative spermatocyte homolog 2 (Drosophila), lipid desaturase [Mus musculus]
GI:27754029 SwissProt Q8R2F2.1 323 RecName: Full=Sphingolipid delta(4)-desaturase/C4-hydroxylase DES2; AltName: Full=Degenerative spermatocyte homolog 2 [Mus musculus]

Related Sequences to LMP002220 proteins

Reference Database Accession Length Protein Name
GI:283483988 DBBJ BAE37145.1 286 unnamed protein product [Mus musculus]
GI:27754029 EMBL CAI79417.1 323 rat sphingolipid desaturase [Rattus norvegicus]
GI:283483988 GenBank AAM12533.1 323 sphingolipid delta 4 desaturase/C-4 hydroxylase protein DES2 [Mus musculus]
GI:27754029 GenBank AAH98701.1 323 Degenerative spermatocyte homolog 2, lipid desaturase (Drosophila) [Rattus norvegicus]
GI:283483988 GenBank AAH16427.2 323 Degenerative spermatocyte homolog 2 (Drosophila), lipid desaturase [Mus musculus]
GI:27754029 GenBank EDL18708.1 348 degenerative spermatocyte homolog 2 (Drosophila), lipid desaturase [Mus musculus]
GI:283483988 GenBank EDL18708.1 348 degenerative spermatocyte homolog 2 (Drosophila), lipid desaturase [Mus musculus]
GI:27754029 GenBank EDL97561.1 342 degenerative spermatocyte homolog 2 (Drosophila), lipid desaturase [Rattus norvegicus]
GI:283483988 RefSeq NP_081575.2 323 sphingolipid delta(4)-desaturase/C4-hydroxylase DES2 isoform 1 [Mus musculus]
GI:27754029 RefSeq NP_001017457.1 323 sphingolipid delta(4)-desaturase/C4-hydroxylase DES2 [Rattus norvegicus]
GI:27754029 SwissProt Q564G3.1 323 RecName: Full=Sphingolipid delta(4)-desaturase/C4-hydroxylase DES2; AltName: Full=Degenerative spermatocyte homolog 2 [Rattus norvegicus]
GI:283483988 SwissProt Q8R2F2.1 323 RecName: Full=Sphingolipid delta(4)-desaturase/C4-hydroxylase DES2; AltName: Full=Degenerative spermatocyte homolog 2 [Mus musculus]