Gene/Proteome Database (LMPD)

LMPD ID
LMP002204
Gene ID
16952
Species
Mus musculus (Mouse)
Gene Name
annexin A1
Gene Symbol
Anxa1
Synonyms
Anx-1; Anx-A1; C430014K04Rik; Lpc-1; Lpc1
Alternate Names
annexin A1; p35; annexin I; annexin-1; calpactin-2; calpactin II; lipocortin 1; lipocortin I; chromobindin-9; phospholipase A2 inhibitory protein
Chromosome
19
Map Location
19 B|19 13.83 cM

Proteins

annexin A1
Refseq ID NP_034860
Protein GI 124517663
UniProt ID P10107
mRNA ID NM_010730
Length 346
RefSeq Status PROVISIONAL
MAMVSEFLKQARFLENQEQEYVQAVKSYKGGPGSAVSPYPSFNVSSDVAALHKAIMVKGVDEATIIDILTKRTNAQRQQIKAAYLQENGKPLDEVLRKALTGHLEEVVLAMLKTPAQFDADELRGAMKGLGTDEDTLIEILTTRSNEQIREINRVYREELKRDLAKDITSDTSGDFRKALLALAKGDRCQDLSVNQDLADTDARALYEAGERRKGTDVNVFTTILTSRSFPHLRRVFQNYGKYSQHDMNKALDLELKGDIEKCLTTIVKCATSTPAFFAEKLYEAMKGAGTRHKALIRIMVSRSEIDMNEIKVFYQKKYGISLCQAILDETKGDYEKILVALCGGN

Gene Information

Entrez Gene ID
16952
Gene Name
annexin A1
Gene Symbol
Anxa1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0009986 IEA:Ensembl C cell surface
GO:0005929 IEA:UniProtKB-KW C cilium
GO:0001533 IEA:Ensembl C cornified envelope
GO:0005615 IEA:Ensembl C extracellular space
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0031966 IEA:Ensembl C mitochondrial membrane
GO:0005634 IEA:UniProtKB-KW C nucleus
GO:0043234 IEA:Ensembl C protein complex
GO:0042383 IDA:MGI C sarcolemma
GO:0005509 IEA:InterPro F calcium ion binding
GO:0005544 IEA:UniProtKB-KW F calcium-dependent phospholipid binding
GO:0019834 IEA:UniProtKB-KW F phospholipase A2 inhibitor activity
GO:0005198 IEA:Ensembl F structural molecule activity
GO:0046632 IMP:BHF-UCL P alpha-beta T cell differentiation
GO:0050482 IMP:MGI P arachidonic acid secretion
GO:0007166 IEA:Ensembl P cell surface receptor signaling pathway
GO:0071385 IEA:Ensembl P cellular response to glucocorticoid stimulus
GO:0070301 IEA:Ensembl P cellular response to hydrogen peroxide
GO:0031018 IEA:Ensembl P endocrine pancreas development
GO:0060206 IEA:Ensembl P estrous cycle phase
GO:0042063 IEA:Ensembl P gliogenesis
GO:0070365 IEA:Ensembl P hepatocyte differentiation
GO:0030073 IEA:Ensembl P insulin secretion
GO:0030216 IEA:Ensembl P keratinocyte differentiation
GO:0002674 IEA:Ensembl P negative regulation of acute inflammatory response
GO:0043066 IEA:Ensembl P negative regulation of apoptotic process
GO:2000483 IEA:Ensembl P negative regulation of interleukin-8 secretion
GO:0097350 IEA:Ensembl P neutrophil clearance
GO:0001780 IMP:BHF-UCL P neutrophil homeostasis
GO:0018149 IEA:Ensembl P peptide cross-linking
GO:1900087 IMP:MGI P positive regulation of G1/S transition of mitotic cell cycle
GO:0033031 IMP:BHF-UCL P positive regulation of neutrophil apoptotic process
GO:0031394 IEA:Ensembl P positive regulation of prostaglandin biosynthetic process
GO:0031340 IEA:Ensembl P positive regulation of vesicle fusion
GO:0042127 IMP:MGI P regulation of cell proliferation
GO:0010165 IEA:Ensembl P response to X-ray
GO:0042493 IEA:Ensembl P response to drug
GO:0032355 IEA:Ensembl P response to estradiol
GO:0070555 IEA:Ensembl P response to interleukin-1
GO:0043434 IEA:Ensembl P response to peptide hormone
GO:0007165 IMP:MGI P signal transduction

REACTOME Pathway Links

REACTOME Pathway ID Description
5893711 Formyl peptide receptors bind formyl peptides and many other ligands
5893663 G alpha (i) signalling events

Domain Information

InterPro Annotations

Accession Description
IPR001464 Annexin
IPR018252 Annexin repeat, conserved site
IPR002388 Annexin, type I
IPR018502 Annexin_repeat

UniProt Annotations

Entry Information

Gene Name
annexin A1
Protein Entry
ANXA1_MOUSE
UniProt ID
P10107
Species
Mouse

Comments

Comment Type Description
Domain A pair of annexin repeats may form one binding site for calcium and phospholipid.
Function Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity.
Ptm Phosphorylated by protein kinase C, epidermal growth factor receptor/kinase and TRPM7. Phosphorylation results in loss of the inhibitory activity (By similarity). {ECO:0000250}.
Similarity Belongs to the annexin family. {ECO:0000305}.
Similarity Contains 4 annexin repeats. {ECO:0000305}.
Subcellular Location Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Cell projection, cilium {ECO:0000250}. Basolateral cell membrane {ECO:0000250}. Note=Found in the cilium, nucleus and basolateral cell membrane of ciliated cells in the tracheal endothelium. Found in the cytoplasm of type II pneumocytes and alveolar macrophages. {ECO:0000250}.
Subunit Homodimer in placenta (20%); linked by transglutamylation. Interacts with DYSF. {ECO:0000269|PubMed:14506282}.

Identical and Related Proteins

Unique RefSeq proteins for LMP002204 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
124517663 RefSeq NP_034860 346 annexin A1

Identical Sequences to LMP002204 proteins

Reference Database Accession Length Protein Name
GI:124517663 DBBJ BAE31766.1 346 unnamed protein product [Mus musculus]
GI:124517663 DBBJ BAE29662.1 346 unnamed protein product [Mus musculus]
GI:124517663 DBBJ BAE29796.1 346 unnamed protein product [Mus musculus]
GI:124517663 DBBJ BAE39665.1 346 unnamed protein product [Mus musculus]
GI:124517663 EMBL CAJ18506.1 346 Anxa1 [Mus musculus]
GI:124517663 GenBank AEU43381.1 346 Sequence 130 from patent US 8052970

Related Sequences to LMP002204 proteins

Reference Database Accession Length Protein Name
GI:124517663 DBBJ BAE32038.1 346 unnamed protein product [Mus musculus]
GI:124517663 EMBL CAJ18120.1 346 Anxa1 [Mus musculus]
GI:124517663 GenBank AAA39437.1 346 lipocortin I [Mus musculus domesticus]
GI:124517663 GenBank AAB19866.1 346 lipocortin I [Rattus sp.]
GI:124517663 GenBank AAA39420.1 341 lipocortin I protein, partial [Mus musculus]
GI:124517663 GenBank ACG75704.1 346 annexin A1 [Mus musculus]