Gene/Proteome Database (LMPD)

LMPD ID
LMP002187
Gene ID
3632
Species
Homo sapiens (Human)
Gene Name
inositol polyphosphate-5-phosphatase, 40kDa
Gene Symbol
INPP5A
Synonyms
5PTASE
Alternate Names
type I inositol 1,4,5-trisphosphate 5-phosphatase; InsP3 5-phosphatase; CTCL tumor antigen HD-CL-02; 43 kDa inositol polyphosphate 5-phophatase; inositol polyphosphate-5-phosphatase, 40kD; inositol trisphosphate-5-phosphatase, 40kD; type I inositol-1,4,5-trisphosphate 5-phophatase; type I inositol-1,4,5-trisphosphate 5-phosphatase
Chromosome
10
Map Location
10q26.3
EC Number
3.1.3.56
Summary
The protein encoded by this gene is a membrane-associated type I inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for INPP5A

Proteins

type I inositol 1,4,5-trisphosphate 5-phosphatase
Refseq ID NP_005530
Protein GI 109702906
UniProt ID Q14642
mRNA ID NM_005539
Length 412
RefSeq Status REVIEWED
MAGKAAAPGTAVLLVTANVGSLFDDPENLQKNWLREFYQVVHTHKPHFMALHCQEFGGKNYEASMSHVDKFVKELLSSDAMKEYNRARVYLDENYKSQEHFTALGSFYFLHESLKNIYQFDFKAKKYRKVAGKEIYSDTLESTPMLEKEKFPQDYFPECKWSRKGFIRTRWCIADCAFDLVNIHLFHDASNLVAWETSPSVYSGIRHKALGYVLDRIIDQRFEKVSYFVFGDFNFRLDSKSVVETLCTKATMQTVRAADTNEVVKLIFRESDNDRKVMLQLEKKLFDYFNQEVFRDNNGTALLEFDKELSVFKDRLYELDISFPPSYPYSEDARQGEQYMNTRCPAWCDRILMSPSAKELVLRSESEEKVVTYDHIGPNVCMGDHKPVFLAFRIMPGAGKPHAHVHKCCVVQ

Gene Information

Entrez Gene ID
3632
Gene Name
inositol polyphosphate-5-phosphatase, 40kDa
Gene Symbol
INPP5A
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0070062 IDA:UniProt C extracellular vesicular exosome
GO:0016020 NAS:UniProtKB C membrane
GO:0005886 TAS:Reactome C plasma membrane
GO:0042731 IPI:BHF-UCL F PH domain binding
GO:0052659 IEA:UniProtKB-EC F inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity
GO:0052658 IEA:UniProtKB-EC F inositol-1,4,5-trisphosphate 5-phosphatase activity
GO:0004445 NAS:UniProtKB F inositol-polyphosphate 5-phosphatase activity
GO:0043647 TAS:Reactome P inositol phosphate metabolic process
GO:0046856 IEA:InterPro P phosphatidylinositol dephosphorylation
GO:0044281 TAS:Reactome P small molecule metabolic process

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-6362 1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)
PWY-6364 D-myo-inositol (1,3,4)-trisphosphate biosynthesis
PWY-6363 D-myo-inositol (1,4,5)-trisphosphate degradation

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_150352 Synthesis of IP2, IP, and Ins in the cytosol

Domain Information

InterPro Annotations

Accession Description
IPR005135 Endonuclease/exonuclease/phosphatase
IPR000300 Inositol polyphosphate-related phosphatase

UniProt Annotations

Entry Information

Gene Name
inositol polyphosphate-5-phosphatase, 40kDa
Protein Entry
I5P1_HUMAN
UniProt ID
Q14642
Species
Human

Comments

Comment Type Description
Catalytic Activity 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H(2)O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate.
Catalytic Activity D-myo-inositol 1,4,5-trisphosphate + H(2)O = myo-inositol 1,4-bisphosphate + phosphate.
Function Major isoenzyme hydrolyzing the calcium-mobilizing second messenger Ins(1,4,5)P3, this is a signal-terminating reaction.
Interaction P08567:PLEK; NbExp=4; IntAct=EBI-8670520, EBI-2565501;
Similarity Belongs to the inositol 1,4,5-trisphosphate 5- phosphatase type I family.
Subcellular Location Membrane; Lipid-anchor.
Tissue Specificity Brain; high level in Purkinje cells.

Identical and Related Proteins

Unique RefSeq proteins for LMP002187 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
109702906 RefSeq NP_005530 412 type I inositol 1,4,5-trisphosphate 5-phosphatase

Identical Sequences to LMP002187 proteins

Reference Database Accession Length Protein Name
GI:109702906 GenBank JAA04190.1 412 inositol polyphosphate-5-phosphatase, 40kDa [Pan troglodytes]
GI:109702906 GenBank JAA14785.1 412 inositol polyphosphate-5-phosphatase, 40kDa [Pan troglodytes]
GI:109702906 GenBank JAA32426.1 412 inositol polyphosphate-5-phosphatase, 40kDa [Pan troglodytes]
GI:109702906 GenBank JAA33673.1 412 inositol polyphosphate-5-phosphatase, 40kDa [Pan troglodytes]
GI:109702906 GenBank AIC49068.1 412 INPP5A, partial [synthetic construct]
GI:109702906 RefSeq XP_001155993.2 412 PREDICTED: type I inositol 1,4,5-trisphosphate 5-phosphatase [Pan troglodytes]

Related Sequences to LMP002187 proteins

Reference Database Accession Length Protein Name
GI:109702906 GenBank AFE78130.1 412 type I inositol-1,4,5-trisphosphate 5-phosphatase [Macaca mulatta]
GI:109702906 RefSeq XP_004625616.1 412 PREDICTED: type I inositol 1,4,5-trisphosphate 5-phosphatase [Octodon degus]
GI:109702906 RefSeq XP_005402104.1 412 PREDICTED: type I inositol 1,4,5-trisphosphate 5-phosphatase isoform X1 [Chinchilla lanigera]
GI:109702906 RefSeq XP_005566831.1 412 PREDICTED: type I inositol 1,4,5-trisphosphate 5-phosphatase isoform X1 [Macaca fascicularis]
GI:109702906 RefSeq XP_007962675.1 412 PREDICTED: type I inositol 1,4,5-trisphosphate 5-phosphatase isoform X6 [Chlorocebus sabaeus]
GI:109702906 RefSeq XP_010381043.1 412 PREDICTED: type I inositol 1,4,5-trisphosphate 5-phosphatase isoform X1 [Rhinopithecus roxellana]