Gene/Proteome Database (LMPD)

LMPD ID
LMP002169
Gene ID
170826
Species
Mus musculus (Mouse)
Gene Name
peroxisome proliferative activated receptor, gamma, coactivator 1 beta
Gene Symbol
Ppargc1b
Synonyms
4631412G21Rik; Perc
Alternate Names
peroxisome proliferator-activated receptor gamma coactivator 1-beta; PGC-1beta; PGC-1-beta; ERR ligand 1; PPARGC-1-beta; PGC-1beta/ERRL1; PPAR-gamma coactivator 1-beta; PPAR gamma coactivator-1beta protein; peroxisome proliferator-activated receptor gamma coactivator 1 beta
Chromosome
18
Map Location
18 E1|18

Proteins

peroxisome proliferator-activated receptor gamma coactivator 1-beta
Refseq ID NP_573512
Protein GI 18875426
UniProt ID Q8VHJ7
mRNA ID NM_133249
Length 1014
RefSeq Status PROVISIONAL
MAGNDCGALLDEELSSFFLNYLSDTQGGDSGEEQLCADLPELDLSQLDASDFDSATCFGELQWCPETSETEPSQYSPDDSELFQIDSENEALLAALTKTLDDIPEDDVGLAAFPELDEGDTPSCTPASPAPLSAPPSPTLERLLSPASDVDELSLLQKLLLATSSPTASSDALKDGATWSQTSLSSRSQRPCVKVDGTQDKKTPTLRAQSRPCTELHKHLTSVLPCPRVKACSPTPHPSPRLLSKEEEEEVGEDCPSPWPTPASPQDSLAQDTASPDSAQPPEEDVRAMVQLIRYMHTYCLPQRKLPQRAPEPIPQACSSLSRQVQPRSRHPPKAFWTEFSILRELLAQDILCDVSKPYRLAIPVYASLTPQSRPRPPKDSQASPAHSAMAEEVRITASPKSTGPRPSLRPLRLEVKRDVNKPTRQKREEDEEEEEEEEEEEEEKEEEEEEWGRKRPGRGLPWTKLGRKMDSSVCPVRRSRRLNPELGPWLTFTDEPLGALPSMCLDTETHNLEEDLGSLTDSSQGRQLPQGSQIPALESPCESGCGDTDEDPSCPQPTSRDSSRCLMLALSQSDSLGKKSFEESLTVELCGTAGLTPPTTPPYKPMEEDPFKPDTKLSPGQDTAPSLPSPEALPLTATPGASHKLPKRHPERSELLSHLQHATTQPVSQAGQKRPFSCSFGDHDYCQVLRPEAALQRKVLRSWEPIGVHLEDLAQQGAPLPTETKAPRREANQNCDPTHKDSMQLRDHEIRASLTKHFGLLETALEGEDLASCKSPEYDTVFEDSSSSSGESSFLLEEEEEEEEGGEEDDEGEDSGVSPPCSDHCPYQSPPSKASRQLCSRSRSSSGSSSCSSWSPATRKNFRRESRGPCSDGTPSVRHARKRREKAIGEGRVVYIRNLSSDMSSRELKKRFEVFGEIVECQVLTRSKRGQKHGFITFRCSEHAALSVRNGATLRKRNEPSFHLSYGGLRHFRWPRYTDYDPTSEESLPSSGKSKYEAMDFDSLLKEAQQSLH

Gene Information

Entrez Gene ID
170826
Gene Name
peroxisome proliferative activated receptor, gamma, coactivator 1 beta
Gene Symbol
Ppargc1b
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016592 IEA:Ensembl C mediator complex
GO:0005739 IMP:GOC C mitochondrion
GO:0005634 ISS:UniProtKB C nucleus
GO:0050682 ISS:UniProtKB F AF-2 domain binding
GO:0003723 IEA:UniProtKB-KW F RNA binding
GO:0001104 IEA:Ensembl F RNA polymerase II transcription cofactor activity
GO:0030374 ISS:UniProtKB F ligand-dependent nuclear receptor transcription coactivator activity
GO:0000166 IEA:InterPro F nucleotide binding
GO:0030546 IEA:Ensembl F receptor activator activity
GO:0007015 IMP:DFLAT P actin filament organization
GO:0060346 IMP:DFLAT P bone trabecula formation
GO:0034614 IDA:DFLAT P cellular response to reactive oxygen species
GO:0030520 ISS:UniProtKB P intracellular estrogen receptor signaling pathway
GO:0045892 IMP:DFLAT P negative regulation of transcription, DNA-templated
GO:0001503 IMP:DFLAT P ossification
GO:0010694 IMP:DFLAT P positive regulation of alkaline phosphatase activity
GO:0045780 IMP:DFLAT P positive regulation of bone resorption
GO:0045672 IMP:DFLAT P positive regulation of osteoclast differentiation
GO:0042327 IMP:DFLAT P positive regulation of phosphorylation
GO:0045944 ISS:UniProtKB P positive regulation of transcription from RNA polymerase II promoter
GO:0045893 IMP:DFLAT P positive regulation of transcription, DNA-templated
GO:0006355 ISS:UniProtKB P regulation of transcription, DNA-templated
GO:0051591 IEA:Ensembl P response to cAMP
GO:0051384 IEA:Ensembl P response to glucocorticoid
GO:0006390 IMP:DFLAT P transcription from mitochondrial promoter

REACTOME Pathway Links

REACTOME Pathway ID Description
5893843 PPARA activates gene expression

Domain Information

InterPro Annotations

Accession Description
IPR012677 Nucleotide-binding alpha-beta plait domain
IPR000504 RNA recognition motif domain

UniProt Annotations

Entry Information

Gene Name
peroxisome proliferative activated receptor, gamma, coactivator 1 beta
Protein Entry
PRGC2_MOUSE
UniProt ID
Q8VHJ7
Species
Mouse

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8VHJ7-1; Sequence=Displayed; Name=2; IsoId=Q8VHJ7-2; Sequence=VSP_019302;
Domain Contains 3 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motif, which are usually required for the association with nuclear receptors. {ECO:0000250}.
Function Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcritional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be part of the pathways regulating the elevation of gluconeogenesis, beta- oxidation of fatty acids and ketogenesis during fasting. Stimulates SREBP-mediated lipogenic gene expression in the liver. Induces energy expenditure and antagonizes obesity when overexpressed. Induces also the expression of mitochondrial genes involved in oxidative metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. {ECO:0000269|PubMed:11733490, ECO:0000269|PubMed:12678921, ECO:0000269|PubMed:14530391, ECO:0000269|PubMed:15680331}.
Induction Induced by fasting in the liver, but not by cold exposure in brown adipose tissue. Induced also by saturated fatty acids in primary hepatocytes. {ECO:0000269|PubMed:11733490, ECO:0000269|PubMed:15680331}.
Miscellaneous Transgenic mice overexpressing PPARGC1B exhibits increased expression of medium-chain acyl CoA dehydrogenase. They are hyperphagic but lean, with increased energy expenditure and resistance to obesity.
Similarity Contains 1 RRM (RNA recognition motif) domain. {ECO:0000255|PROSITE-ProRule:PRU00176}.
Subcellular Location Nucleus {ECO:0000250}.
Subunit Interacts with estrogen receptor alpha/ESR1 (By similarity). Interacts with hepatocyte nuclear factor 4- alpha/HNF4A, Sterol regulatory binding transcription factor 1/SREBF1, PPAR-alpha/PPARA, thyroid hormone receptor beta/THRB and host cell factor/HCFC1. Interacts with estrogen-related receptor gamma/ESRRG and alpha/ESRRA. Interacts with PRDM16. {ECO:0000250, ECO:0000269|PubMed:11733490, ECO:0000269|PubMed:12470660, ECO:0000269|PubMed:14530391, ECO:0000269|PubMed:15680331, ECO:0000269|PubMed:17618855, ECO:0000269|PubMed:18483224}.
Tissue Specificity Ubiquitous with higher expression in heart, brown adipose tissue, brain and skeletal muscle. {ECO:0000269|PubMed:11733490, ECO:0000269|PubMed:12678921}.

Identical and Related Proteins

Unique RefSeq proteins for LMP002169 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
18875426 RefSeq NP_573512 1014 peroxisome proliferator-activated receptor gamma coactivator 1-beta

Identical Sequences to LMP002169 proteins

Reference Database Accession Length Protein Name
GI:18875426 GenBank AAL47054.1 1014 PPAR gamma coactivator-1beta protein [Mus musculus]
GI:18875426 GenBank EDL09777.1 1014 peroxisome proliferative activated receptor, gamma, coactivator 1 beta, isoform CRA_c [Mus musculus]
GI:18875426 SwissProt Q8VHJ7.1 1014 RecName: Full=Peroxisome proliferator-activated receptor gamma coactivator 1-beta; Short=PGC-1-beta; Short=PPAR-gamma coactivator 1-beta; Short=PPARGC-1-beta; AltName: Full=ERR ligand 1 [Mus musculus]

Related Sequences to LMP002169 proteins

Reference Database Accession Length Protein Name
GI:18875426 DBBJ BAC25964.1 1030 unnamed protein product [Mus musculus]
GI:18875426 GenBank EDL09776.1 1052 peroxisome proliferative activated receptor, gamma, coactivator 1 beta, isoform CRA_b, partial [Mus musculus]
GI:18875426 GenBank EDM14599.1 1010 peroxisome proliferative activated receptor, gamma, coactivator 1 beta, isoform CRA_b [Rattus norvegicus]
GI:18875426 GenBank AAI50700.1 1014 Peroxisome proliferative activated receptor, gamma, coactivator 1 beta [Mus musculus]
GI:18875426 RefSeq XP_006525761.1 1046 PREDICTED: peroxisome proliferator-activated receptor gamma coactivator 1-beta isoform X1 [Mus musculus]
GI:18875426 SwissProt Q811R2.2 1010 RecName: Full=Peroxisome proliferator-activated receptor gamma coactivator 1-beta; Short=PGC-1-beta; Short=PPAR-gamma coactivator 1-beta; Short=PPARGC-1-beta [Rattus norvegicus]