Gene/Proteome Database (LMPD)

LMPD ID
LMP002155
Gene ID
39
Species
Homo sapiens (Human)
Gene Name
acetyl-CoA acetyltransferase 2
Gene Symbol
ACAT2
Synonyms
-
Alternate Names
acetyl-CoA acetyltransferase, cytosolic; acetoacetyl Coenzyme A thiolase; cytosolic acetoacetyl-CoA thiolase; acetyl-CoA transferase-like protein
Chromosome
6
Map Location
6q25.3
EC Number
2.3.1.9
Summary
The product of this gene is an enzyme involved in lipid metabolism, and it encodes cytosolic acetoacetyl-CoA thiolase. This gene shows complementary overlapping with the 3-prime region of the TCP1 gene in both mouse and human. These genes are encoded on opposite strands of DNA, as well as in opposite transcriptional orientation. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for ACAT2

Proteins

acetyl-CoA acetyltransferase, cytosolic
Refseq ID NP_005882
Protein GI 148539872
UniProt ID Q9BWD1
mRNA ID NM_005891
Length 397
RefSeq Status REVIEWED
MNAGSDPVVIVSAARTIIGSFNGALAAVPVQDLGSTVIKEVLKRATVAPEDVSEVIFGHVLAAGCGQNPVRQASVGAGIPYSVPAWSCQMICGSGLKAVCLAVQSIGIGDSSIVVAGGMENMSKAPHLAYLRTGVKIGEMPLTDSILCDGLTDAFHNCHMGITAENVAKKWQVSREDQDKVAVLSQNRTENAQKAGHFDKEIVPVLVSTRKGLIEVKTDEFPRHGSNIEAMSKLKPYFLTDGTGTVTPANASGINDGAAAVVLMKKSEADKRGLTPLARIVSWSQVGVEPSIMGIGPIPAIKQAVTKAGWSLEDVDIFEINEAFAAVSAAIVKELGLNPEKVNIEGGAIALGHPLGASGCRILVTLLHTLERMGRSRGVAALCIGGGMGIAMCVQRE

Gene Information

Entrez Gene ID
39
Gene Name
acetyl-CoA acetyltransferase 2
Gene Symbol
ACAT2
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IDA:BHF-UCL C cytoplasm
GO:0070062 IDA:UniProtKB C extracellular vesicular exosome
GO:0005730 IDA:HPA C nucleolus
GO:0005634 IDA:HPA C nucleus
GO:0003985 IDA:BHF-UCL F acetyl-CoA C-acetyltransferase activity
GO:0006629 IC:BHF-UCL P lipid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa01200 Carbon metabolism
hsa04975 Fat digestion and absorption
hsa00900 Terpenoid backbone biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR002155 Thiolase
IPR020617 Thiolase, C-terminal
IPR020616 Thiolase, N-terminal
IPR020610 Thiolase, active site
IPR020613 Thiolase, conserved site
IPR016039 Thiolase-like
IPR016038 Thiolase-like, subgroup

UniProt Annotations

Entry Information

Gene Name
acetyl-CoA acetyltransferase 2
Protein Entry
THIC_HUMAN
UniProt ID
Q9BWD1
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9BWD1-1; Sequence=Displayed; Name=2; IsoId=Q9BWD1-2; Sequence=VSP_056217; Note=No experimental confirmation available.;
Catalytic Activity 2 acetyl-CoA = CoA + acetoacetyl-CoA.
Similarity Belongs to the thiolase family.
Subcellular Location Cytoplasm.
Subunit Homotetramer.

Identical and Related Proteins

Unique RefSeq proteins for LMP002155 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
148539872 RefSeq NP_005882 397 acetyl-CoA acetyltransferase, cytosolic

Identical Sequences to LMP002155 proteins

Reference Database Accession Length Protein Name
GI:148539872 GenBank ADS87547.1 397 Sequence 423 from patent US 7820380
GI:148539872 GenBank ADS87548.1 397 Sequence 424 from patent US 7820380
GI:148539872 GenBank ADS87549.1 397 Sequence 425 from patent US 7820380
GI:148539872 GenBank AEW40542.1 397 Sequence 423 from patent US 8071302
GI:148539872 GenBank AEW40543.1 397 Sequence 424 from patent US 8071302
GI:148539872 GenBank AEW40544.1 397 Sequence 425 from patent US 8071302

Related Sequences to LMP002155 proteins

Reference Database Accession Length Protein Name
GI:148539872 DBBJ BAG10670.1 397 acetyl-CoA acetyltransferase, partial [synthetic construct]
GI:148539872 GenBank AAH00408.1 397 ACAT2 protein [Homo sapiens]
GI:148539872 GenBank ACM84545.1 409 Sequence 10043 from patent US 6812339
GI:148539872 GenBank ACM84546.1 409 Sequence 10044 from patent US 6812339
GI:148539872 GenBank ADQ32668.1 397 acetyl-Coenzyme A acetyltransferase 2 (acetoacetyl Coenzyme A thiolase), partial [synthetic construct]
GI:148539872 GenBank AIC53943.1 397 ACAT2, partial [synthetic construct]