Gene/Proteome Database (LMPD)

LMPD ID
LMP002121
Gene ID
52858
Species
Mus musculus (Mouse)
Gene Name
CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)
Gene Symbol
Cdipt
Synonyms
9530042F15Rik; D7Bwg0575e; Pis; Pis1
Alternate Names
CDP-diacylglycerol--inositol 3-phosphatidyltransferase; PI synthase; ptdIns synthase; phosphatidylinositol synthase
Chromosome
7
Map Location
7 F4|7 69.26 cM
EC Number
2.7.8.11

Proteins

CDP-diacylglycerol--inositol 3-phosphatidyltransferase
Refseq ID NP_080914
Protein GI 28076897
UniProt ID Q8VDP6
mRNA ID NM_026638
Length 213
RefSeq Status VALIDATED
MPEENIFLFVPNLIGYARIVFAIISFYFMPCCPFTASSFYLLSGLLDAFDGHAARALNQGTRFGAMLDMLTDRCATMCLLVNLALLYPRATLLFQLSMSLDVASHWLHLHSSVVRGSESHKMIDLSGNPVLRIYYTSRPALFTLCAGNELFYCLLYLFNFSEGPLVGSVGLFRMGLWVTAPIALLKSVISVIHLITAARNMAALDAADRAKKK

Gene Information

Entrez Gene ID
52858
Gene Name
CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)
Gene Symbol
Cdipt
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 IEA:UniProtKB-KW C Golgi apparatus
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0016021 ISS:UniProtKB C integral component of membrane
GO:0005886 IEA:UniProtKB-KW C plasma membrane
GO:0003881 ISS:UniProtKB F CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity
GO:0043178 IEA:Ensembl F alcohol binding
GO:0030246 IEA:Ensembl F carbohydrate binding
GO:0019992 IEA:Ensembl F diacylglycerol binding
GO:0030145 IEA:Ensembl F manganese ion binding
GO:0046341 IEA:Ensembl P CDP-diacylglycerol metabolic process
GO:0006661 ISS:UniProtKB P phosphatidylinositol biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu00564 Glycerophospholipid metabolism
mmu00562 Inositol phosphate metabolism

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-6351 D-myo-inositol (1,4,5)-trisphosphate biosynthesis
PWY3DJ-219 PIP metabolism

Domain Information

InterPro Annotations

Accession Description
IPR000462 CDP-alcohol phosphatidyltransferase
IPR014387 CDP-diacylglycerol-inositol 3-phosphatidyltransferase, eukaryote

UniProt Annotations

Entry Information

Gene Name
CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)
Protein Entry
CDIPT_MOUSE
UniProt ID
Q8VDP6
Species
Mouse

Comments

Comment Type Description
Catalytic Activity CDP-diacylglycerol + myo-inositol = CMP + phosphatidyl-1D-myo-inositol.
Cofactor Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250}; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Note=Divalent metal cations; Mn(2+) or Mg(2+), but Mg(2+) may be much less effective. {ECO:0000250};
Function Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns:inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content. The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme (By similarity). {ECO:0000250}.
Similarity Belongs to the CDP-alcohol phosphatidyltransferase class-I family. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Membrane {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP002121 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
28076897 RefSeq NP_080914 213 CDP-diacylglycerol--inositol 3-phosphatidyltransferase

Identical Sequences to LMP002121 proteins

Reference Database Accession Length Protein Name
GI:28076897 DBBJ BAC36542.1 213 unnamed protein product [Mus musculus]
GI:28076897 DBBJ BAC37580.1 213 unnamed protein product [Mus musculus]
GI:28076897 DBBJ BAC40756.1 213 unnamed protein product [Mus musculus]
GI:28076897 GenBank AAH21473.1 213 CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase) [Mus musculus]
GI:28076897 GenBank AAH24413.1 213 CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase) [Mus musculus]
GI:28076897 SwissProt Q8VDP6.1 213 RecName: Full=CDP-diacylglycerol--inositol 3-phosphatidyltransferase; AltName: Full=Phosphatidylinositol synthase; Short=PI synthase; Short=PtdIns synthase [Mus musculus]

Related Sequences to LMP002121 proteins

Reference Database Accession Length Protein Name
GI:28076897 DBBJ BAA11634.1 213 phosphatidylinositol synthase [Rattus norvegicus]
GI:28076897 DBBJ BAA82112.1 213 phosphatidylinositol synthase [Rattus norvegicus]
GI:28076897 GenBank AAQ80838.1 213 Sequence 3 from patent US 6395468
GI:28076897 RefSeq NP_620254.1 213 CDP-diacylglycerol--inositol 3-phosphatidyltransferase [Rattus norvegicus]
GI:28076897 RefSeq XP_006230270.1 213 PREDICTED: CDP-diacylglycerol--inositol 3-phosphatidyltransferase isoform X1 [Rattus norvegicus]
GI:28076897 SwissProt P70500.1 213 RecName: Full=CDP-diacylglycerol--inositol 3-phosphatidyltransferase; AltName: Full=Phosphatidylinositol synthase; Short=PI synthase; Short=PtdIns synthase [Rattus norvegicus]