Gene/Proteome Database (LMPD)

LMPD ID
LMP002106
Gene ID
5331
Species
Homo sapiens (Human)
Gene Name
phospholipase C, beta 3 (phosphatidylinositol-specific)
Gene Symbol
PLCB3
Synonyms
-
Alternate Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3; PLC beta 3; PLC-beta-3; phosphoinositide phospholipase C-beta-3
Chromosome
11
Map Location
11q13
EC Number
3.1.4.11
Summary
This gene encodes a member of the phosphoinositide phospholipase C beta enzyme family that catalyze the production of the secondary messengers diacylglycerol and inositol 1,4,5-triphosphate from phosphatidylinositol in G-protein-linked receptor-mediated signal transduction. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Orthologs
View orthologs and multiple alignments for PLCB3

Proteins

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform 1
Refseq ID NP_000923
Protein GI 11386139
UniProt ID Q01970
mRNA ID NM_000932
Length 1234
RefSeq Status REVIEWED
MAGAQPGVHALQLEPPTVVETLRRGSKFIKWDEETSSRNLVTLRVDPNGFFLYWTGPNMEVDTLDISSIRDTRTGRYARLPKDPKIREVLGFGGPDARLEEKLMTVVSGPDPVNTVFLNFMAVQDDTAKVWSEELFKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNILKMFSADKKRVETALESCGLKFNRSESIRPDEFSLEIFERFLNKLCLRPDIDKILLEIGAKGKPYLTLEQLMDFINQKQRDPRLNEVLYPPLRPSQARLLIEKYEPNQQFLERDQMSMEGFSRYLGGEENGILPLEALDLSTDMTQPLSAYFINSSHNTYLTAGQLAGTSSVEMYRQALLWGCRCVELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVILSFENHVDSAKQQAKMAEYCRSIFGDALLIEPLDKYPLAPGVPLPSPQDLMGRILVKNKKRHRPSAGGPDSAGRKRPLEQSNSALSESSAATEPSSPQLGSPSSDSCPGLSNGEEVGLEKPSLEPQKSLGDEGLNRGPYVLGPADREDEEEDEEEEEQTDPKKPTTDEGTASSEVNATEEMSTLVNYIEPVKFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNYMPQLFWNVGCQLVALNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIVDGIVANALRVKVISGQFLSDRKVGIYVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWDEEPFDFPKVVLPTLASLRIAAFEEGGKFVGHRILPVSAIRSGYHYVCLRNEANQPLCLPALLIYTEASDYIPDDHQDYAEALINPIKHVSLMDQRARQLAALIGESEAQAGQETCQDTQSQQLGSQPSSNPTPSPLDASPRRPPGPTTSPASTSLSSPGQRDDLIASILSEVAPTPLDELRGHKALVKLRSRQERDLRELRKKHQRKAVTLTRRLLDGLAQAQAEGRCRLRPGALGGAADVEDTKEGEDEAKRYQEFQNRQVQSLLELREAQVDAEAQRRLEHLRQALQRLREVVLDANTTQFKRLKEMNEREKKELQKILDRKRHNSISEAKMRDKHKKEAELTEINRRHITESVNSIRRLEEAQKQRHDRLVAGQQQVLQQLAEEEPKLLAQLAQECQEQRARLPQEIRRSLLGEMPEGLGDGPLVACASNGHAPGSSGHLSGADSESQEENTQL
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform 2
Refseq ID NP_001171812
Protein GI 296531339
UniProt ID Q01970
mRNA ID NM_001184883
Length 1167
RefSeq Status REVIEWED
MAGAQPGVHALQLEPPTVVETLRRGSKFIKWDEEKLMTVVSGPDPVNTVFLNFMAVQDDTAKVWSEELFKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNILKMFSADKKRVETALESCGLKFNRSESIRPDEFSLEIFERFLNKLCLRPDIDKILLEIGAKGKPYLTLEQLMDFINQKQRDPRLNEVLYPPLRPSQARLLIEKYEPNQQFLERDQMSMEGFSRYLGGEENGILPLEALDLSTDMTQPLSAYFINSSHNTYLTAGQLAGTSSVEMYRQALLWGCRCVELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVILSFENHVDSAKQQAKMAEYCRSIFGDALLIEPLDKYPLAPGVPLPSPQDLMGRILVKNKKRHRPSAGGPDSAGRKRPLEQSNSALSESSAATEPSSPQLGSPSSDSCPGLSNGEEVGLEKPSLEPQKSLGDEGLNRGPYVLGPADREDEEEDEEEEEQTDPKKPTTDEGTASSEVNATEEMSTLVNYIEPVKFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNYMPQLFWNVGCQLVALNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIVDGIVANALRVKVISGQFLSDRKVGIYVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWDEEPFDFPKVVLPTLASLRIAAFEEGGKFVGHRILPVSAIRSGYHYVCLRNEANQPLCLPALLIYTEASDYIPDDHQDYAEALINPIKHVSLMDQRARQLAALIGESEAQAGQETCQDTQSQQLGSQPSSNPTPSPLDASPRRPPGPTTSPASTSLSSPGQRDDLIASILSEVAPTPLDELRGHKALVKLRSRQERDLRELRKKHQRKAVTLTRRLLDGLAQAQAEGRCRLRPGALGGAADVEDTKEGEDEAKRYQEFQNRQVQSLLELREAQVDAEAQRRLEHLRQALQRLREVVLDANTTQFKRLKEMNEREKKELQKILDRKRHNSISEAKMRDKHKKEAELTEINRRHITESVNSIRRLEEAQKQRHDRLVAGQQQVLQQLAEEEPKLLAQLAQECQEQRARLPQEIRRSLLGEMPEGLGDGPLVACASNGHAPGSSGHLSGADSESQEENTQL

Gene Information

Entrez Gene ID
5331
Gene Name
phospholipase C, beta 3 (phosphatidylinositol-specific)
Gene Symbol
PLCB3
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 TAS:Reactome C cytosol
GO:0016020 IEA:UniProtKB-KW C membrane
GO:0005634 IDA:HPA C nucleus
GO:0043234 IDA:MGI C protein complex
GO:0005509 IEA:InterPro F calcium ion binding
GO:0005516 IPI:BHF-UCL F calmodulin binding
GO:0004435 IEA:UniProtKB-EC F phosphatidylinositol phospholipase C activity
GO:0004629 TAS:ProtInc F phospholipase C activity
GO:0004871 IEA:UniProtKB-KW F signal transducer activity
GO:0043647 TAS:Reactome P inositol phosphate metabolic process
GO:0035556 IEA:InterPro P intracellular signal transduction
GO:0016042 IEA:UniProtKB-KW P lipid catabolic process
GO:0003073 IDA:MGI P regulation of systemic arterial blood pressure
GO:0044281 TAS:Reactome P small molecule metabolic process
GO:0007268 TAS:Reactome P synaptic transmission

KEGG Pathway Links

KEGG Pathway ID Description
hsa04750 Inflammatory mediator regulation of TRP channels
hsa04921 Oxytocin signaling pathway
hsa04611 Platelet activation
hsa04022 cGMP-PKG signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR028390 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
IPR000008 C2 domain
IPR011992 EF-hand domain pair
IPR014815 PLC-beta, C-terminal
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain
IPR016280 Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta
IPR009535 Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta, conserved site
IPR001192 Phosphoinositide phospholipase C family
IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like
IPR011993 Pleckstrin homology-like domain

UniProt Annotations

Entry Information

Gene Name
phospholipase C, beta 3 (phosphatidylinositol-specific)
Protein Entry
PLCB3_HUMAN
UniProt ID
Q01970
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q01970-1; Sequence=Displayed; Name=2; IsoId=Q01970-2; Sequence=VSP_046054; Note=No experimental confirmation available.;
Catalytic Activity 1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
Cofactor Name=Ca(2+); Xref=ChEBI
Function The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
Sequence Caution Sequence=AAH32659.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence= ;
Similarity Contains 1 C2 domain. {ECO
Similarity Contains 1 PI-PLC X-box domain. {ECO
Similarity Contains 1 PI-PLC Y-box domain. {ECO
Subcellular Location Membrane; Peripheral membrane protein.
Subunit Interacts with SHANK2 (By similarity). Interacts with LPAR2.

Identical and Related Proteins

Unique RefSeq proteins for LMP002106 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
11386139 RefSeq NP_000923 1234 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform 1
296531339 RefSeq NP_001171812 1167 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform 2

Identical Sequences to LMP002106 proteins

Reference Database Accession Length Protein Name
GI:11386139 EMBL CBU87762.1 1234 unnamed protein product [Homo sapiens]
GI:11386139 EMBL CBU96709.1 1234 unnamed protein product [Homo sapiens]
GI:296531339 GenBank EAW74231.1 1167 phospholipase C, beta 3 (phosphatidylinositol-specific), isoform CRA_b [Homo sapiens]
GI:11386139 GenBank AED62136.1 1234 Sequence 18 from patent US 7902154
GI:11386139 GenBank AGX54697.1 1234 Sequence 9750 from patent US 8541208
GI:11386139 GenBank AGX64137.1 1234 Sequence 28384 from patent US 8541208
GI:11386139 RefSeq XP_005274109.1 1234 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [Homo sapiens]

Related Sequences to LMP002106 proteins

Reference Database Accession Length Protein Name
GI:296531339 DBBJ BAG10887.1 1234 phospholipase B, delta 3, partial [synthetic construct]
GI:296531339 GenBank AAH32659.1 1191 Similar to phospholipase C, beta 3 (phosphatidylinositol-specific), partial [Homo sapiens]
GI:296531339 GenBank EAW74230.1 1234 phospholipase C, beta 3 (phosphatidylinositol-specific), isoform CRA_a [Homo sapiens]
GI:296531339 GenBank AED62136.1 1234 Sequence 18 from patent US 7902154
GI:11386139 GenBank JAA04641.1 1234 phospholipase C, beta 3 (phosphatidylinositol-specific) [Pan troglodytes]
GI:11386139 GenBank JAA16357.1 1234 phospholipase C, beta 3 (phosphatidylinositol-specific) [Pan troglodytes]
GI:11386139 GenBank JAA28799.1 1234 phospholipase C, beta 3 (phosphatidylinositol-specific) [Pan troglodytes]
GI:11386139 RefSeq XP_003274203.1 1234 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [Nomascus leucogenys]
GI:11386139 RefSeq XP_003313091.1 1234 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [Pan troglodytes]
GI:11386139 RefSeq XP_003828610.1 1234 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [Pan paniscus]
GI:296531339 RefSeq XP_005577489.1 1167 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X3 [Macaca fascicularis]
GI:296531339 SwissProt Q01970.2 1234 RecName: Full=1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3; AltName: Full=Phosphoinositide phospholipase C-beta-3; AltName: Full=Phospholipase C-beta-3; Short=PLC-beta-3 [Homo sapiens]