Gene/Proteome Database (LMPD)

LMPD ID
LMP002097
Gene ID
15378
Species
Mus musculus (Mouse)
Gene Name
hepatic nuclear factor 4, alpha
Gene Symbol
Hnf4a
Synonyms
HNF-4; Hnf4; Hnf4alpha; MODY1; Nr2a1; Tcf14
Alternate Names
hepatocyte nuclear factor 4-alpha; TCF-14; HNF4 alpha; HNF-4-alpha; HNF4alpha10; HNF4alpha11; HNF4alpha12; Nuclear receptor 2A1; transcription factor 14; transcription factor HNF-4; nuclear receptor subfamily 2 group A member 1
Chromosome
2
Map Location
2 H3|2 84.32 cM

Proteins

hepatocyte nuclear factor 4-alpha
Refseq ID NP_032287
Protein GI 46575916
UniProt ID P49698
mRNA ID NM_008261
Length 474
RefSeq Status PROVISIONAL
MRLSKTLAGMDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGANLNSSNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSQQITSPISGINGDIRAKKIANITDVCESMKEQLLVLVEWAKYIPAFCELLLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYACLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSASDAPHTHHPLHPHLMQEHMGTNVIVANTMPSHLSNGQMCEWPRPRGQAATPETPQPSPPSGSGSESYKLLPGAITTIVKPPSAIPQPTITKQEAI

Gene Information

Entrez Gene ID
15378
Gene Name
hepatic nuclear factor 4, alpha
Gene Symbol
Hnf4a
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 TAS:Reactome C cytosol
GO:0005634 IDA:MGI C nucleus
GO:0003677 IDA:MGI F DNA binding
GO:0001102 IPI:BHF-UCL F RNA polymerase II activating transcription factor binding
GO:0000979 IDA:MGI F RNA polymerase II core promoter sequence-specific DNA binding
GO:0003705 IDA:MGI F RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005504 IEA:Ensembl F fatty acid binding
GO:0004879 IEA:InterPro F ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0043565 IDA:MGI F sequence-specific DNA binding
GO:0003700 IDA:BHF-UCL F sequence-specific DNA binding transcription factor activity
GO:0003707 IEA:InterPro F steroid hormone receptor activity
GO:0044212 IDA:BHF-UCL F transcription regulatory region DNA binding
GO:0008270 IEA:InterPro F zinc ion binding
GO:0060395 IDA:MGI P SMAD protein signal transduction
GO:0007596 IEA:Ensembl P blood coagulation
GO:0031018 TAS:Reactome P endocrine pancreas development
GO:0042593 IMP:BHF-UCL P glucose homeostasis
GO:0006629 IMP:MGI P lipid metabolic process
GO:0030308 IEA:Ensembl P negative regulation of cell growth
GO:0008285 IEA:Ensembl P negative regulation of cell proliferation
GO:0006591 IEA:Ensembl P ornithine metabolic process
GO:0055091 IMP:BHF-UCL P phospholipid homeostasis
GO:2000189 IMP:BHF-UCL P positive regulation of cholesterol homeostasis
GO:0045944 IDA:BHF-UCL P positive regulation of transcription from RNA polymerase II promoter
GO:0045893 IDA:MGI P positive regulation of transcription, DNA-templated
GO:0010470 IMP:MGI P regulation of gastrulation
GO:0050796 IMP:BHF-UCL P regulation of insulin secretion
GO:0019216 IEA:Ensembl P regulation of lipid metabolic process
GO:0006357 IMP:MGI P regulation of transcription from RNA polymerase II promoter
GO:0006355 IMP:MGI P regulation of transcription, DNA-templated
GO:0009749 IMP:BHF-UCL P response to glucose
GO:0007548 IMP:MGI P sex differentiation
GO:0023019 IDA:MGI P signal transduction involved in regulation of gene expression
GO:0006366 IDA:GOC P transcription from RNA polymerase II promoter
GO:0070328 IMP:BHF-UCL P triglyceride homeostasis
GO:0006805 IEA:Ensembl P xenobiotic metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu04152 AMPK signaling pathway
mmu04950 Maturity onset diabetes of the young

REACTOME Pathway Links

REACTOME Pathway ID Description
5893658 Nuclear Receptor transcription pathway

Domain Information

InterPro Annotations

Accession Description
IPR008946 Nuclear hormone receptor, ligand-binding
IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001723 Steroid hormone receptor
IPR003068 Transcription factor COUP
IPR013088 Zinc finger, NHR/GATA-type
IPR001628 Zinc finger, nuclear hormone receptor-type

UniProt Annotations

Entry Information

Gene Name
hepatic nuclear factor 4, alpha
Protein Entry
HNF4A_MOUSE
UniProt ID
P49698
Species
Mouse

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=Long; IsoId=P49698-1; Sequence=Displayed; Name=Short; IsoId=P49698-2; Sequence=VSP_003676;
Function Transcriptionally controlled transcription factor. Binds to DNA sites required for the transcription of alpha 1- antitrypsin, apolipoprotein CIII, transthyretin genes and HNF1- alpha. May be essential for development of the liver, kidney and intestine.
Miscellaneous Binds fatty acids. {ECO:0000250}.
Ptm Acetylation at Lys-458 lowers transcriptional activation by about two-fold. {ECO:0000250}.
Ptm Phosphorylated on tyrosine residue(s); phosphorylation is important for its DNA-binding activity. Phosphorylation may directly or indirectly play a regulatory role in the subnuclear distribution. Phosphorylation at Ser-313 by AMPK reduces the ability to form homodimers and bind DNA (By similarity). {ECO:0000250}.
Sequence Caution Sequence=BAA06101.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Similarity Belongs to the nuclear hormone receptor family. NR2 subfamily. {ECO:0000305}.
Similarity Contains 1 nuclear receptor DNA-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00407}.
Subcellular Location Nucleus.
Subunit Homodimerization is required for HNF4-alpha to bind to its recognition site. Interacts with PER2. {ECO:0000269|PubMed:20159955}.

Identical and Related Proteins

Unique RefSeq proteins for LMP002097 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
46575916 RefSeq NP_032287 474 hepatocyte nuclear factor 4-alpha

Identical Sequences to LMP002097 proteins

Reference Database Accession Length Protein Name
GI:46575916 GenBank AAH39220.1 474 Hepatic nuclear factor 4, alpha [Mus musculus]
GI:46575916 GenBank AAX90602.1 474 hepatic nuclear factor 4 alpha [Mus musculus]
GI:46575916 SwissProt P49698.2 474 RecName: Full=Hepatocyte nuclear factor 4-alpha; Short=HNF-4-alpha; AltName: Full=Nuclear receptor subfamily 2 group A member 1; AltName: Full=Transcription factor 14; Short=TCF-14; AltName: Full=Transcription factor HNF-4 [Mus musculus]

Related Sequences to LMP002097 proteins

Reference Database Accession Length Protein Name
GI:46575916 DBBJ BAE25624.1 470 unnamed protein product, partial [Mus musculus]
GI:46575916 GenBank EDL96572.1 474 hepatocyte nuclear factor 4, alpha, isoform CRA_a [Rattus norvegicus]
GI:46575916 GenBank ERE70975.1 474 hepatocyte nuclear factor 4-alpha-like isoform 1 [Cricetulus griseus]
GI:46575916 RefSeq NP_071516.2 474 hepatocyte nuclear factor 4-alpha isoform 1 [Rattus norvegicus]
GI:46575916 RefSeq XP_006971086.1 474 PREDICTED: hepatocyte nuclear factor 4-alpha isoform X1 [Peromyscus maniculatus bairdii]
GI:46575916 SwissProt P22449.3 474 RecName: Full=Hepatocyte nuclear factor 4-alpha; Short=HNF-4-alpha; AltName: Full=Nuclear receptor subfamily 2 group A member 1; AltName: Full=Transcription factor 14; Short=TCF-14; AltName: Full=Transcription factor HNF-4 [Rattus norvegicus]