Gene/Proteome Database (LMPD)
LMPD ID
LMP002075
Gene ID
Species
Mus musculus (Mouse)
Gene Name
phospholipase C, delta 4
Gene Symbol
Synonyms
4921507K24Rik
Alternate Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4; PLC-delta-4; phospholipase C-delta-4; phosphoinositide phospholipase C-delta-4; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-4
Chromosome
1
Map Location
1 C3|1 38.54 cM
EC Number
3.1.4.11
Proteins
| 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform 1 | |
|---|---|
| Refseq ID | NP_001074925 |
| Protein GI | 125347158 |
| UniProt ID | Q8K3R3 |
| mRNA ID | NM_001081456 |
| Length | 775 |
| RefSeq Status | VALIDATED |
| MTSQIQDLLATDQDLLLMQEGTMMRKVRTKSWKKLRYFRLQNDGMTVWHGSQPESMPKPTFSISDVERIRKGQDSELLRYLVEEFPLEQGFTVVFHGRRPNLDLVANSVEEAQIWMRGLQLLVDLVASMDHQEQMDQMLNEWFQQADRNQDGRMSFREAQRLLLLMNVEMDEEYAFSLFQEADVTQSDDLGSEEFVQFYKALTKRTEIEEIFEDFSSDKQKLTLLEFVDFLRKEQKEKDHAPDLALELIDRYEPSENGRLLHVLSKDGFLKYLCSKDGNIFNSDCLPIYQDMTQPLSHYYINSSHNTYLVGDQLCGQSSVEGYIRALKRGCRCVEVDTWDGPDGEPVVYHGHTLTSRILFKDVLATLAQYAFQSSDYPLILSLENHCTWEQQRTMAHHLTEILGEQLLRNTLEGLLVDSMPSPEQLRGKILVKGKKLRTIEVDKEEEEEEEEEELEKDEGPDLDPASPELDTQPQPETQGQAAGNKKERKKKFLLLSSTTIMCPDLSALVVYLRTVPFCSFTHSKENYHIYDISSFSESKAKNLIKEAGNEFVQHNARQLCRVYPSGLRTDSSNFNPQEHWNVGCQMVAMNMQTAGSAMDICDGLFRQNGGSGYVLKPEFLRDTQSSFNPERPISLYKAQILVVQVISGQQLPKVDKTKETTVVDPLVKVELYGVPEDTKEQETSHVENNGINPYWGETFYFRLQVPELAMLRFVVKDYSRKSRNNFIGQYTLPWTCMKQGYRHVSLLSRDGTSLNPASIFVYTCMQEDLDMDEP | |
| 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform 2 | |
|---|---|
| Refseq ID | NP_683739 |
| Protein GI | 125347171 |
| UniProt ID | Q8K3R3 |
| mRNA ID | NM_148937 |
| Length | 807 |
| RefSeq Status | VALIDATED |
| MTSQIQDLLATDQDLLLMQEGTMMRKVRTKSWKKLRYFRLQNDGMTVWHGSQPESMPKPTFSISDVERIRKGQDSELLRYLVEEFPLEQGFTVVFHGRRPNLDLVANSVEEAQIWMRGLQLLVDLVASMDHQEQMDQMLNEWFQQADRNQDGRMSFREAQRLLLLMNVEMDEEYAFSLFQEADVTQSDDLGSEEFVQFYKALTKRTEIEEIFEDFSSDKQKLTLLEFVDFLRKEQKEKDHAPDLALELIDRYEPSENGRLLHVLSKDGFLKYLCSKDGNIFNSDCLPIYQDMTQPLSHYYINSSHNTYLVGDQLCGQSSVEGYIRALKRGCRCVEVDTWDGPDGEPVVYHGHTLTSRILFKDVLATLAQYAFQSSDYPLILSLENHCTWEQQRTMAHHLTEILGEQLLRNTLEGLLVDSMPSPEQLRGKILVKGKKLRTIEVDKEEEEEEEEEELEKDEGPDLDPASPELDTQPQPETQGQAAGNKKERKKKVMKCPMSCLLICGHVMAQAPSSIPESILLSKQFLLLSSTTIMCPDLSALVVYLRTVPFCSFTHSKENYHIYDISSFSESKAKNLIKEAGNEFVQHNARQLCRVYPSGLRTDSSNFNPQEHWNVGCQMVAMNMQTAGSAMDICDGLFRQNGGSGYVLKPEFLRDTQSSFNPERPISLYKAQILVVQVISGQQLPKVDKTKETTVVDPLVKVELYGVPEDTKEQETSHVENNGINPYWGETFYFRLQVPELAMLRFVVKDYSRKSRNNFIGQYTLPWTCMKQGYRHVSLLSRDGTSLNPASIFVYTCMQEDLDMDEP | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005783 | IEA:UniProtKB-KW | C | endoplasmic reticulum |
| GO:0005622 | IDA:MGI | C | intracellular |
| GO:0016020 | IEA:UniProtKB-KW | C | membrane |
| GO:0005634 | IEA:UniProtKB-KW | C | nucleus |
| GO:0005509 | IEA:InterPro | F | calcium ion binding |
| GO:0004435 | IEA:UniProtKB-EC | F | phosphatidylinositol phospholipase C activity |
| GO:0004629 | TAS:MGI | F | phospholipase C activity |
| GO:0004871 | IEA:UniProtKB-KW | F | signal transducer activity |
| GO:0007340 | IMP:MGI | P | acrosome reaction |
| GO:0035556 | IEA:InterPro | P | intracellular signal transduction |
| GO:0016042 | IEA:UniProtKB-KW | P | lipid catabolic process |
| GO:0046488 | TAS:MGI | P | phosphatidylinositol metabolic process |
| GO:0007165 | TAS:MGI | P | signal transduction |
KEGG Pathway Links
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR028387 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 |
| IPR000008 | C2 domain |
| IPR002048 | EF-hand domain |
| IPR011992 | EF-hand domain pair |
| IPR017946 | PLC-like phosphodiesterase, TIM beta/alpha-barrel domain |
| IPR001192 | Phosphoinositide phospholipase C family |
| IPR000909 | Phospholipase C, phosphatidylinositol-specific , X domain |
| IPR001711 | Phospholipase C, phosphatidylinositol-specific, Y domain |
| IPR015359 | Phospholipase C, phosphoinositol-specific, EF-hand-like |
| IPR001849 | Pleckstrin homology domain |
| IPR011993 | Pleckstrin homology-like domain |
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8K3R3-1; Sequence=Displayed; Name=2; IsoId=Q8K3R3-2; Sequence=VSP_028503; Note=No experimental confirmation available.; Name=3; IsoId=Q8K3R3-3; Sequence=VSP_028503, VSP_028506; Note=No experimental confirmation available.; Name=4; IsoId=Q8K3R3-4; Sequence=VSP_028504, VSP_028505; Note=No experimental confirmation available.; |
| Catalytic Activity | 1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol. |
| Cofactor | Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250}; Note=Binds 3 Ca(2+) ions per subunit. Two of the Ca(2+) ions are bound to the C2 domain. {ECO:0000250}; |
| Disruption Phenotype | Mice are either sterile or produce few small litters. In these mice, fewer eggs become activated and the Ca(2+) transients associated with fertilization are absent or delayed. Sperm are unable to initiate the acrosome reaction. {ECO:0000269|PubMed:11340203}. |
| Domain | The C2 domain mediates pre-localization to the membrane prior to Ca(2+) import and non-selective Ca(2+)-mediated targeting to various cellular membranes. {ECO:0000250}. |
| Domain | The PDZ-binding motif mediates the interaction with GRIP1. |
| Domain | The PH domain is not a critical determinant of the membrane localization. {ECO:0000250}. |
| Function | Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida- induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation. {ECO:0000269|PubMed:11340203, ECO:0000269|PubMed:12695499, ECO:0000269|PubMed:16998201}. |
| Induction | By treatment with growth factors such as bradykinin, lysophosphatidic acid, and Ca(2+) ionophore in addition to serum. {ECO:0000269|PubMed:10601847}. |
| Similarity | Contains 1 C2 domain. {ECO:0000255|PROSITE- ProRule:PRU00041}. |
| Similarity | Contains 1 PH domain. {ECO:0000255|PROSITE- ProRule:PRU00145}. |
| Similarity | Contains 1 PI-PLC X-box domain. {ECO:0000255|PROSITE- ProRule:PRU00270}. |
| Similarity | Contains 1 PI-PLC Y-box domain. {ECO:0000255|PROSITE- ProRule:PRU00271}. |
| Similarity | Contains 3 EF-hand domains. {ECO:0000255|PROSITE- ProRule:PRU00448}. |
| Subcellular Location | Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Note=Localizes primarily to intracellular membranes mostly to the endoplasmic reticulum. {ECO:0000250}. |
| Subunit | Interacts with GRIP1. {ECO:0000269|PubMed:16272139}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP002075 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 125347158 | RefSeq | NP_001074925 | 775 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform 1 |
| 125347171 | RefSeq | NP_683739 | 807 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform 2 |
Identical Sequences to LMP002075 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:125347171 | RefSeq | XP_006495851.1 | 807 | PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X6 [Mus musculus] |
| GI:125347171 | SwissProt | Q8K3R3.2 | 807 | RecName: Full=1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4; AltName: Full=Phosphoinositide phospholipase C-delta-4; AltName: Full=Phospholipase C-delta-4; Short=PLC-delta-4 [Mus musculus] |
Related Sequences to LMP002075 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:125347158 | GenBank | AAK61537.1 | 807 | phospholipase C delta 4 [Mus musculus] |
| GI:125347171 | GenBank | AAK61537.1 | 807 | phospholipase C delta 4 [Mus musculus] |
| GI:125347158 | GenBank | AAH66156.1 | 775 | Phospholipase C, delta 4 [Mus musculus] |
| GI:125347171 | GenBank | EDL00331.1 | 809 | phospholipase C, delta 4, isoform CRA_a [Mus musculus] |
| GI:125347158 | RefSeq | NP_683739.2 | 807 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform 2 [Mus musculus] |
| GI:125347171 | RefSeq | XP_006495846.1 | 833 | PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1 [Mus musculus] |
| GI:125347171 | RefSeq | XP_006495847.1 | 833 | PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X2 [Mus musculus] |
| GI:125347171 | RefSeq | XP_006495848.1 | 833 | PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X3 [Mus musculus] |
| GI:125347171 | RefSeq | XP_006495849.1 | 833 | PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X4 [Mus musculus] |
| GI:125347158 | RefSeq | XP_006495851.1 | 807 | PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X6 [Mus musculus] |
| GI:125347158 | RefSeq | XP_006495852.1 | 801 | PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X7 [Mus musculus] |
| GI:125347158 | SwissProt | Q8K3R3.2 | 807 | RecName: Full=1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4; AltName: Full=Phosphoinositide phospholipase C-delta-4; AltName: Full=Phospholipase C-delta-4; Short=PLC-delta-4 [Mus musculus] |