Gene/Proteome Database (LMPD)

LMPD ID
LMP002068
Gene ID
4540
Species
Homo sapiens (Human)
Gene Name
NADH dehydrogenase, subunit 5 (complex I)
Gene Symbol
ND5
Synonyms
MTND5
Chromosome
MT
Map Location
-
EC Number
1.6.5.3 ;

Proteins

NADH dehydrogenase subunit 5 (mitochondrion)
Refseq ID YP_003024036
Protein GI 251831117
UniProt ID U5ZC31
Length 603
MTMHTTMTTLTLTSLIPPILTTLVNPNKKNSYPHYVKSIVASTFIISLFPTTMFMCLDQEVIISNWHWATTQTTQLSLSFKLDYFSMMFIPVALFVTWSIMEFSLWYMNSDPNINQFFKYLLIFLITMLILVTANNLFQLFIGWEGVGIMSFLLISWWYARADANTAAIQAILYNRIGDIGFILALAWFILHSNSWDPQQMALLNANPSLTPLLGLLLAAAGKSAQLGLHPWLPSAMEGPTPVSALLHSSTMVVAGIFLLIRFHPLAENSPLIQTLTLCLGAITTLFAAVCALTQNDIKKIVAFSTSSQLGLMMVTIGINQPHLAFLHICTHAFFKAMLFMCSGSIIHNLNNEQDIRKMGGLLKTMPLTSTSLTIGSLALAGMPFLTGFYSKDHIIETANMSYTNAWALSITLIATSLTSAYSTRMILLTLTGQPRFPTLTNINENNPTLLNPIKRLAAGSLFAGFLITNNISPASPFQTTIPLYLKLTALAVTFLGLLTALDLNYLTNKLKMKSPLCTFYFSNMLGFYPSITHRTIPYLGLLTSQNLPLLLLDLTWLEKLLPKTISQHQISTSIITSTQKGMIKLYFLSFFFPLILTLLLIT

Gene Information

Entrez Gene ID
4540
Gene Name
NADH dehydrogenase, subunit 5 (complex I)
Gene Symbol
ND5
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005743 IEA:UniProtKB-SubCell C mitochondrial inner membrane
GO:0070469 IEA:UniProtKB-KW C respiratory chain
GO:0008137 IEA:UniProtKB-EC F NADH dehydrogenase (ubiquinone) activity
GO:0042773 IEA:InterPro P ATP synthesis coupled electron transport

KEGG Pathway Links

KEGG Pathway ID Description
hsa05012 Parkinson's disease

Domain Information

InterPro Annotations

Accession Description
IPR010934 NADH dehydrogenase subunit 5, C-terminal
IPR003945 NADH-plastoquinone oxidoreductase, chain 5
IPR001750 NADH:quinone oxidoreductase/Mrp antiporter, membrane subunit
IPR001516 NADH:ubiquinone oxidoreductase, chain 5/L, N-terminal

UniProt Annotations

Entry Information

Gene Name
NADH dehydrogenase, subunit 5 (complex I)
Protein Entry
U5ZC31_HUMAN
UniProt ID
U5ZC31
Species
Human

Comments

Comment Type Description
Catalytic Activity NADH + ubiquinone + 5 H(+)(In) = NAD(+) + ubiquinol + 4 H(+)(Out). {ECO:0000256|RuleBase:RU003404, ECO:0000256|SAAS:SAAS00061104}.
Function Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Similarity Belongs to the complex I subunit 5 family
Subcellular Location Mitochondrion inner membrane ; Multi-pass membrane protein {ECO:0000256|RuleBase:RU003404, ECO:0000256|SAAS:SAAS00061113}.

Identical and Related Proteins

Unique RefSeq proteins for LMP002068 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
251831117 RefSeq YP_003024036 603 NADH dehydrogenase subunit 5 (mitochondrion)

Identical Sequences to LMP002068 proteins

Reference Database Accession Length Protein Name

Related Sequences to LMP002068 proteins

Reference Database Accession Length Protein Name