Gene/Proteome Database (LMPD)

LMPD ID
LMP002016
Gene ID
5406
Species
Homo sapiens (Human)
Gene Name
pancreatic lipase
Gene Symbol
PNLIP
Synonyms
PL; PNLIPD; PTL
Alternate Names
pancreatic triacylglycerol lipase; triacylglycerol acylhydrolase
Chromosome
10
Map Location
10q26.1
EC Number
3.1.1.3
Summary
This gene is a member of the lipase gene family. It encodes a carboxyl esterase that hydrolyzes insoluble, emulsified triglycerides, and is essential for the efficient digestion of dietary fats. This gene is expressed specifically in the pancreas. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for PNLIP

Proteins

pancreatic triacylglycerol lipase precursor
Refseq ID NP_000927
Protein GI 10835000
UniProt ID P16233
mRNA ID NM_000936
Length 465
RefSeq Status REVIEWED
MLPLWTLSLLLGAVAGKEVCYERLGCFSDDSPWSGITERPLHILPWSPKDVNTRFLLYTNENPNNFQEVAADSSSISGSNFKTNRKTRFIIHGFIDKGEENWLANVCKNLFKVESVNCICVDWKGGSRTGYTQASQNIRIVGAEVAYFVEFLQSAFGYSPSNVHVIGHSLGAHAAGEAGRRTNGTIGRITGLDPAEPCFQGTPELVRLDPSDAKFVDVIHTDGAPIVPNLGFGMSQVVGHLDFFPNGGVEMPGCKKNILSQIVDIDGIWEGTRDFAACNHLRSYKYYTDSIVNPDGFAGFPCASYNVFTANKCFPCPSGGCPQMGHYADRYPGKTNDVGQKFYLDTGDASNFARWRYKVSVTLSGKKVTGHILVSLFGNKGNSKQYEIFKGTLKPDSTHSNEFDSDVDVGDLQMVKFIWYNNVINPTLPRVGASKIIVETNVGKQFNFCSPETVREEVLLTLTPC
sig_peptide: 1..16 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1655 peptide sequence: MLPLWTLSLLLGAVAG mat_peptide: 17..465 product: pancreatic triacylglycerol lipase calculated_mol_wt: 49520 peptide sequence: KEVCYERLGCFSDDSPWSGITERPLHILPWSPKDVNTRFLLYTNENPNNFQEVAADSSSISGSNFKTNRKTRFIIHGFIDKGEENWLANVCKNLFKVESVNCICVDWKGGSRTGYTQASQNIRIVGAEVAYFVEFLQSAFGYSPSNVHVIGHSLGAHAAGEAGRRTNGTIGRITGLDPAEPCFQGTPELVRLDPSDAKFVDVIHTDGAPIVPNLGFGMSQVVGHLDFFPNGGVEMPGCKKNILSQIVDIDGIWEGTRDFAACNHLRSYKYYTDSIVNPDGFAGFPCASYNVFTANKCFPCPSGGCPQMGHYADRYPGKTNDVGQKFYLDTGDASNFARWRYKVSVTLSGKKVTGHILVSLFGNKGNSKQYEIFKGTLKPDSTHSNEFDSDVDVGDLQMVKFIWYNNVINPTLPRVGASKIIVETNVGKQFNFCSPETVREEVLLTLTPC

Gene Information

Entrez Gene ID
5406
Gene Name
pancreatic lipase
Gene Symbol
PNLIP
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005576 TAS:Reactome C extracellular region
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0004806 TAS:ProtInc F triglyceride lipase activity
GO:0030299 IEA:Ensembl P intestinal cholesterol absorption
GO:0016042 IEA:UniProtKB-KW P lipid catabolic process
GO:0044241 TAS:Reactome P lipid digestion
GO:0007603 TAS:Reactome P phototransduction, visible light
GO:0001523 TAS:Reactome P retinoid metabolic process
GO:0044281 TAS:Reactome P small molecule metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa04975 Fat digestion and absorption
hsa04972 Pancreatic secretion
hsa04977 Vitamin digestion and absorption

Domain Information

InterPro Annotations

Accession Description
IPR029058 Alpha/Beta hydrolase fold
IPR013818 Lipase, N-terminal
IPR008976 Lipase/lipooxygenase, PLAT/LH2
IPR016272 Lipoprotein_lipase_LIPH
IPR001024 PLAT/LH2 domain
IPR002331 Pancreatic lipase
IPR000734 Triacylglycerol lipase family

UniProt Annotations

Entry Information

Gene Name
pancreatic lipase
Protein Entry
LIPP_HUMAN
UniProt ID
P16233
Species
Human

Comments

Comment Type Description
Catalytic Activity Triacylglycerol + H(2)O = diacylglycerol + a carboxylate.
Induction By colipase/CLPS in the presence of bile salts.
Similarity Belongs to the AB hydrolase superfamily. Lipase family.
Similarity Contains 1 PLAT domain. {ECO
Subcellular Location Secreted.
Web Resource Name=Wikipedia; Note=Pancreatic lipase entry; URL="http://en.wikipedia.org/wiki/Pancreatic_lipase";

Identical and Related Proteins

Unique RefSeq proteins for LMP002016 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
10835000 RefSeq NP_000927 465 pancreatic triacylglycerol lipase precursor

Identical Sequences to LMP002016 proteins

Reference Database Accession Length Protein Name
GI:10835000 GenBank ADS21271.1 465 Sequence 14 from patent US 7771960
GI:10835000 GenBank ADZ15379.1 465 pancreatic lipase, partial [synthetic construct]
GI:10835000 GenBank AFG81084.1 465 Sequence 14 from patent US 8138316
GI:10835000 GenBank AGN45444.1 465 Sequence 15 from patent US 8343494
GI:10835000 GenBank AHD76068.1 465 Sequence 18892 from patent US 8586006
GI:10835000 GenBank AIC49423.1 465 PNLIP, partial [synthetic construct]

Related Sequences to LMP002016 proteins

Reference Database Accession Length Protein Name
GI:10835000 EMBL CAA01714.1 450 pancreatic lipase [Homo sapiens]
GI:10835000 PDB 1LPA 449 Chain B, Interfacial Activation Of The Lipase-Procolipase Complex By Mixed Micelles Revealed By X-Ray Crystallography
GI:10835000 RefSeq XP_001151144.1 465 PREDICTED: pancreatic triacylglycerol lipase [Pan troglodytes]
GI:10835000 RefSeq XP_002821218.1 465 PREDICTED: pancreatic triacylglycerol lipase [Pongo abelii]
GI:10835000 RefSeq XP_003825668.1 465 PREDICTED: pancreatic triacylglycerol lipase [Pan paniscus]
GI:10835000 RefSeq XP_004050194.1 465 PREDICTED: pancreatic triacylglycerol lipase [Gorilla gorilla gorilla]