Gene/Proteome Database (LMPD)

LMPD ID
LMP001990
Gene ID
226861
Species
Mus musculus (Mouse)
Gene Name
hedgehog acyltransferase
Gene Symbol
Hhat
Synonyms
2810432O22Rik; AI462858; AP-2CRE; Skn; Tg(TFAP2A-cre)1Will
Alternate Names
protein-cysteine N-palmitoyltransferase HHAT; skinny hedgehog protein
Chromosome
1
Map Location
1 H6|1
EC Number
2.3.1.-

Proteins

protein-cysteine N-palmitoyltransferase HHAT precursor
Refseq ID NP_659130
Protein GI 31559954
UniProt ID Q8BMT9
mRNA ID NM_144881
Length 499
RefSeq Status VALIDATED
MLPGWELTLCLLVSLGFHFRSFYEVYKVSREHEEELDQEFELEMDTLFGGLKKDPTDFEWNFWMEWGKRRLVWLFIGHMAVSQLATLLTKKHRPWIVMVYGMWACWCVLGAPGVVMVLLHSTIAFCVAQFRSVLLSWLCSLLLLSTLRLQSVEEVKRRWYKTENEYYLLQFTLTVRCLYYTSFSLELCRQPPSAQPTPSAQGASHSYPWLLTYVFYYPVFHNGPILNFPEFFRQMQQPELNSLQHSLCIVAKGLGRLLCWWWLAELMVHLMYMHALYSSAPLLESVSCWTLGGLALAQVLFFYVKYLVLFGVPALLMRLDGLTPPPLPRCVSTMFSFTGMWRYFDVGLHNFLIRYVYIPLGGSQHGLLGTLLSTATTFAFVSYWHGSYEDLWCWAALNWLGVTVESGVRRLLETPCVRETLARHLSPQAHHRLHALLAACSTSMLILFNLVFLGGIQVGKTYWNRIFLQGWPWVTLSVLGFLYCYSHVDIAWAQTYTVL
sig_peptide: 1..16 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1745 peptide sequence: MLPGWELTLCLLVSLG

Gene Information

Entrez Gene ID
226861
Gene Name
hedgehog acyltransferase
Gene Symbol
Hhat
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005525 IEA:UniProtKB-KW F GTP binding
GO:0016409 IMP:MGI F palmitoyltransferase activity
GO:0007275 IEA:UniProtKB-KW P multicellular organismal development
GO:0018345 IMP:MGI P protein palmitoylation
GO:0007224 IMP:MGI P smoothened signaling pathway

REACTOME Pathway Links

REACTOME Pathway ID Description
5894154 Hedgehog ligand biogenesis
5894157 Hh ligand biogenesis disease
5894156 Processing-defective Hh variants abrogate ligand secretion
5894155 Signaling by Hedgehog

Domain Information

InterPro Annotations

Accession Description
IPR004299 Membrane bound O-acyl transferase, MBOAT

UniProt Annotations

Entry Information

Gene Name
hedgehog acyltransferase
Protein Entry
HHAT_MOUSE
UniProt ID
Q8BMT9
Species
Mouse

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BMT9-1; Sequence=Displayed; Name=2; IsoId=Q8BMT9-2; Sequence=VSP_016690, VSP_016691; Note=No experimental confirmation available.;
Developmental Stage Broadly expressed from E7. At E10.5, strongly expressed in anterior ectoderm, pharyngeal arches, and distal part of the limb. {ECO:0000269|PubMed:15075292}.
Disruption Phenotype Mice are characterized by a smaller size and holoprosencephaly at E10.5, shortening of limbs at E13.5, and severe short-limb dwarfism at birth. They die soon after birth. {ECO:0000269|PubMed:15075292}.
Function Catalyzes N-terminal palmitoylation of SHH; which is required for SHH signaling during limb development. May bind GTP. {ECO:0000269|PubMed:15075292}.
Similarity Belongs to the membrane-bound acyltransferase family. HHAT subfamily. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:15075292, ECO:0000269|PubMed:18081866}; Multi- pass membrane protein {ECO:0000269|PubMed:15075292, ECO:0000269|PubMed:18081866}.

Identical and Related Proteins

Unique RefSeq proteins for LMP001990 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
31559954 RefSeq NP_659130 499 protein-cysteine N-palmitoyltransferase HHAT precursor

Identical Sequences to LMP001990 proteins

Reference Database Accession Length Protein Name
GI:31559954 DBBJ BAC25829.1 499 unnamed protein product [Mus musculus]
GI:31559954 SwissProt Q8BMT9.1 499 RecName: Full=Protein-cysteine N-palmitoyltransferase HHAT; AltName: Full=Hedgehog acyltransferase; AltName: Full=Skinny hedgehog protein [Mus musculus]

Related Sequences to LMP001990 proteins

Reference Database Accession Length Protein Name
GI:31559954 DBBJ BAE42837.1 499 unnamed protein product [Mus musculus]
GI:31559954 GenBank AAH08159.1 473 Hhat protein [Mus musculus]
GI:31559954 GenBank EDL12965.1 499 hedgehog acyltransferase, isoform CRA_a [Mus musculus]
GI:31559954 GenBank EDL12966.1 473 hedgehog acyltransferase, isoform CRA_b [Mus musculus]
GI:31559954 RefSeq XP_006497314.1 530 PREDICTED: protein-cysteine N-palmitoyltransferase HHAT isoform X1 [Mus musculus]
GI:31559954 RefSeq XP_008768116.1 570 PREDICTED: LOW QUALITY PROTEIN: protein-cysteine N-palmitoyltransferase HHAT isoform X2 [Rattus norvegicus]