Gene/Proteome Database (LMPD)

LMPD ID
LMP001859
Gene ID
329502
Species
Mus musculus (Mouse)
Gene Name
phospholipase A2, group IVE
Gene Symbol
Pla2g4e
Synonyms
2310026J01Rik; C230096D22; Pla2epsilon
Alternate Names
cytosolic phospholipase A2 epsilon; cPLA2-epsilon; phospholipase A2, group 4E
Chromosome
2
Map Location
2 E5|2
EC Number
3.1.1.4

Proteins

cytosolic phospholipase A2 epsilon
Refseq ID NP_808513
Protein GI 63999319
UniProt ID Q50L42
mRNA ID NM_177845
Length 875
RefSeq Status VALIDATED
MQSIPHSDEADVAGMTHASEGHHGLGTSMLVPKNPQGEEDSKLGRNCSGFEDAQDPQTAVPSSPLLSMASCSSQEGSSPCHLLTVRIIGMKNVRQADILSQTDCFVTLWLPTASQKKLKTRTISNCLHPEWDESFTFQIQTQVKNVLELSVCDEDTLTQNDHLLTVLYDLSKLCLRNKTHVKFPLNPEGMEELEVEFLLEENFSSSETLITNGVLVSRQVSCLEVHAESRRPRKRKKNKDLLVMVTDSFENTQRVPPCQEPCYPNSACFHYPKYSQPQLYAEAPKSHCNFRLCCCGTHRNDPVCQPLNCLSDGQVTTLPVGENYELHMKSSPCSDTLDVRLGFSLCQEEVEFVQKRKMVVAKTLSQMLQLEEGLHEDEVPIIAIMATGGGTRSMVSLYGHLLGLQKLNFLDASTYITGLSGATWTMATLYSDPEWSSKNLETVVFEARRHVVKDKMPALFPDQLYKWREDLQKHSQEGYKTTFTDFWGKLIEYSLGDKKNECKLSDQRAALCRGQNPLPIYLTINVKDDVSNQDFREWFEFSPYEVGMQKYGAFIPSELFGSEFFMGRLMKRIPEPEMCYMLGLWSSIFSLNLLDAWNLSHTSEEFFYRWTRERLHDIEDDPILPEIPRCDDNPLETTVVIPTTWLSNTFREILTRRPFVSEFHNFLYGMQLHTDYLQNRQFSMWKDTVLDTFPNQLTQFAKHLNLLDTAFFVNSSYAPLLRPERKVDLIIHLNYCAGSQTKPLKQTCEYCTEQKIPFPSFSILEDDNSLKECYVMENPQEPDAPIVAYFPLISDTFQKYKAPGVERSPDELELGQLNIYGPKSPYATKELTYTEAAFDKLVKLSEYNILNNRDKLIQALRLAMEKKRMRSQCPS

Gene Information

Entrez Gene ID
329502
Gene Name
phospholipase A2, group IVE
Gene Symbol
Pla2g4e
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IDA:MGI C cytoplasm
GO:0005764 IEA:UniProtKB-KW C lysosome
GO:0016020 IEA:UniProtKB-KW C membrane
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0004623 IDA:MGI F phospholipase A2 activity
GO:0009395 IEA:InterPro P phospholipid catabolic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu04750 Inflammatory mediator regulation of TRP channels
mmu04921 Oxytocin signaling pathway
mmu04611 Platelet activation
mmu04014 Ras signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase
IPR000008 C2 domain
IPR002642 Lysophospholipase, catalytic domain

UniProt Annotations

Entry Information

Gene Name
phospholipase A2, group IVE
Protein Entry
PA24E_MOUSE
UniProt ID
Q50L42
Species
Mouse

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q50L42-1; Sequence=Displayed; Name=2; IsoId=Q50L42-2; Sequence=VSP_019884, VSP_019885, VSP_019886; Note=No experimental confirmation available.;
Catalytic Activity Phosphatidylcholine + H(2)O = 1- acylglycerophosphocholine + a carboxylate.
Domain The N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic Ca(2+) (By similarity). {ECO:0000250}.
Enzyme Regulation Stimulated by cytosolic Ca(2+). {ECO:0000250}.
Function Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position. {ECO:0000269|PubMed:15866882}.
Similarity Contains 1 C2 domain. {ECO:0000255|PROSITE- ProRule:PRU00041}.
Similarity Contains 1 PLA2c domain. {ECO:0000255|PROSITE- ProRule:PRU00555}.
Subcellular Location Cytoplasm, cytosol {ECO:0000269|PubMed:15866882}. Lysosome membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=Translocates to lysosomal membranes in a calcium-dependent fashion.
Tissue Specificity Predominantly expressed in heart, skeletal muscle, testis and thyroid. Expressed at lower level in brain and stomach. {ECO:0000269|PubMed:15866882}.

Identical and Related Proteins

Unique RefSeq proteins for LMP001859 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
63999319 RefSeq NP_808513 875 cytosolic phospholipase A2 epsilon

Identical Sequences to LMP001859 proteins

Reference Database Accession Length Protein Name
GI:63999319 DBBJ BAD98153.1 875 cytosolic phospholipase A2 epsilon [Mus musculus]
GI:63999319 GenBank AEU43304.1 875 Sequence 53 from patent US 8052970
GI:63999319 SwissProt Q50L42.1 875 RecName: Full=Cytosolic phospholipase A2 epsilon; Short=cPLA2-epsilon; AltName: Full=Phospholipase A2 group IVE [Mus musculus]

Related Sequences to LMP001859 proteins

Reference Database Accession Length Protein Name
GI:63999319 GenBank AAI37900.1 874 Pla2g4e protein [Mus musculus]
GI:63999319 RefSeq XP_006499832.1 859 PREDICTED: cytosolic phospholipase A2 epsilon isoform X1 [Mus musculus]
GI:63999319 RefSeq XP_006499833.1 835 PREDICTED: cytosolic phospholipase A2 epsilon isoform X2 [Mus musculus]
GI:63999319 RefSeq XP_006499834.1 831 PREDICTED: cytosolic phospholipase A2 epsilon isoform X3 [Mus musculus]
GI:63999319 RefSeq XP_006499835.1 831 PREDICTED: cytosolic phospholipase A2 epsilon isoform X4 [Mus musculus]
GI:63999319 RefSeq XP_006499836.1 786 PREDICTED: cytosolic phospholipase A2 epsilon isoform X5 [Mus musculus]