Gene/Proteome Database (LMPD)

LMPD ID
LMP001858
Gene ID
271844
Species
Mus musculus (Mouse)
Gene Name
phospholipase A2, group IVF
Gene Symbol
Pla2g4f
Synonyms
4732472I07Rik; Gm647; Pla2zeta
Alternate Names
cytosolic phospholipase A2 zeta; cPLA2-zeta
Chromosome
2
Map Location
2 E5|2
EC Number
3.1.1.4

Proteins

cytosolic phospholipase A2 zeta
Refseq ID NP_001019316
Protein GI 67972423
UniProt ID Q50L41
mRNA ID NM_001024145
Length 855
RefSeq Status VALIDATED
MPWTLQPKWLAGKGLPLLGAILLRKTEKSEPQWKHRRQETHPYYDLQVKVLRARNIQHTDKLSKADCYVRLWLPTASVSPSQTRTVVNSSDPEWNETFPYQIHGAVKNVLELALYDEDVLDSDNVFSILFDTSTLQLGQPCTKNFTRQQDPKELEVEFTLEKSQTPASEVVTNGVLVAHPCLRIQGTVTGDKTASLGELGSRQIQLAVPGAYEKPQPLQPTSEPGLPVNFTFHVNPVLSPKLHIKLQEQLQVFHSGPSDELEAQTSKMDKASILLSSLPLNEELTKLVDLEEGQQVSLRMKADMSSSGDLDLRLGFDLCDGEQEFLDKRKQVASKALQRVMGLSEALHCDQVPVVAVLGSGGGTRAMTSLYGSLAGLQELGLLDAVTYLSGVSGSSWCISTLYRDPSWSQKALQGPIKYASERVCSSKIGMLSPKQFEYYSREKRAWESRGHSMSFTDLWGLIIEYFLNQEENPAKLSDQQETVSQGQNPYPIYASINVHKNISGDDFAEWCEFTPYEVGFPKYGAYVPTELFGSEFFMGRLLHFWPEPRICYLQGMWGSAFAASLYEIFLKLGGLSLSFLDWHRGSVSVTDDWPKLRKQDPTRLPTRLFTPMSSFSQAVLDIFTSRITCAQTFNFTRGLCMYKDYTARKDFVVSEDAWHSHNYGYPDACPNQLTPMKDFLSLVDGGFAINSPFPLVLQPQRAVDLIVSFDYSLEGPFEVLQVTEKYCRDRGIPFPRIEVDPKDSEDPRECYLFAEAEDPCSPIVLHFPLVNRTFRTHLAPGVERQTAEEKAFGDFIINGPDTAYGMMDFTYEPKEFDRLVTLSRYNVLNNKETIRHALQLALDRRRQAGGRVGG

Gene Information

Entrez Gene ID
271844
Gene Name
phospholipase A2, group IVF
Gene Symbol
Pla2g4f
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IDA:MGI C cytoplasm
GO:0005829 IDA:MGI C cytosol
GO:0005764 IEA:UniProtKB-KW C lysosome
GO:0032587 IDA:MGI C ruffle membrane
GO:0031982 IDA:MGI C vesicle
GO:0047498 IDA:MGI F calcium-dependent phospholipase A2 activity
GO:0004622 IDA:MGI F lysophospholipase activity
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0004623 IDA:MGI F phospholipase A2 activity
GO:0050482 IDA:MGI P arachidonic acid secretion
GO:0071236 IDA:MGI P cellular response to antibiotic
GO:0071407 IDA:MGI P cellular response to organic cyclic compound
GO:0015908 IDA:MGI P fatty acid transport
GO:0009395 IEA:InterPro P phospholipid catabolic process
GO:0001516 IDA:MGI P prostaglandin biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu04750 Inflammatory mediator regulation of TRP channels
mmu04921 Oxytocin signaling pathway
mmu04611 Platelet activation
mmu04014 Ras signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase
IPR000008 C2 domain
IPR002642 Lysophospholipase, catalytic domain

UniProt Annotations

Entry Information

Gene Name
phospholipase A2, group IVF
Protein Entry
PA24F_MOUSE
UniProt ID
Q50L41
Species
Mouse

Comments

Comment Type Description
Catalytic Activity Phosphatidylcholine + H(2)O = 1- acylglycerophosphocholine + a carboxylate.
Domain The N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic Ca(2+) (By similarity). {ECO:0000250}.
Enzyme Regulation Stimulated by cytosolic Ca(2+). {ECO:0000269|PubMed:15866882}.
Function Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position. Has higher enzyme activity for phosphatidylethanolamine than phosphatidylcholine. {ECO:0000269|PubMed:15866882}.
Sequence Caution Sequence=AAH39947.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Similarity Contains 1 C2 domain. {ECO:0000255|PROSITE- ProRule:PRU00041}.
Similarity Contains 1 PLA2c domain. {ECO:0000255|PROSITE- ProRule:PRU00555}.
Subcellular Location Cytoplasm, cytosol {ECO:0000269|PubMed:15866882}. Lysosome membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=Translocates to lysosomal membranes in a calcium-dependent fashion.
Tissue Specificity Strongly expressed in thyroid, expressed at intermediate level in stomach and at very low level in large intestine and prostate. {ECO:0000269|PubMed:15866882}.

Identical and Related Proteins

Unique RefSeq proteins for LMP001858 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
67972423 RefSeq NP_001019316 855 cytosolic phospholipase A2 zeta

Identical Sequences to LMP001858 proteins

Reference Database Accession Length Protein Name
GI:67972423 DBBJ BAD98154.1 855 cytosolic phospholipase A2 zeta [Mus musculus]
GI:67972423 GenBank AEU43344.1 855 Sequence 93 from patent US 8052970
GI:67972423 SwissProt Q50L41.3 855 RecName: Full=Cytosolic phospholipase A2 zeta; Short=cPLA2-zeta; AltName: Full=Phospholipase A2 group IVF [Mus musculus]

Related Sequences to LMP001858 proteins

Reference Database Accession Length Protein Name
GI:67972423 GenBank ABW43864.1 854 Sequence 22 from patent US 7258855
GI:67972423 GenBank ABW43866.1 853 Sequence 38 from patent US 7258855
GI:67972423 GenBank AEU43286.1 855 Sequence 35 from patent US 8052970
GI:67972423 RefSeq XP_006499712.1 854 PREDICTED: cytosolic phospholipase A2 zeta isoform X1 [Mus musculus]
GI:67972423 RefSeq XP_006499713.1 854 PREDICTED: cytosolic phospholipase A2 zeta isoform X2 [Mus musculus]
GI:67972423 RefSeq XP_006499714.1 853 PREDICTED: cytosolic phospholipase A2 zeta isoform X3 [Mus musculus]