Gene/Proteome Database (LMPD)

LMPD ID
LMP001788
Gene ID
123
Species
Homo sapiens (Human)
Gene Name
perilipin 2
Gene Symbol
PLIN2
Synonyms
ADFP; ADRP
Chromosome
9
Map Location
9p22.1
Summary
The protein encoded by this gene belongs to the perilipin family, members of which coat intracellular lipid storage droplets. This protein is associated with the lipid globule surface membrane material, and maybe involved in development and maintenance of adipose tissue. However, it is not restricted to adipocytes as previously thought, but is found in a wide range of cultured cell lines, including fibroblasts, endothelial and epithelial cells, and tissues, such as lactating mammary gland, adrenal cortex, Sertoli and Leydig cells, and hepatocytes in alcoholic liver cirrhosis, suggesting that it may serve as a marker of lipid accumulation in diverse cell types and diseases. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2011]
Orthologs
View orthologs and multiple alignments for PLIN2

Proteins

perilipin-2
Refseq ID NP_001113
Protein GI 34577059
UniProt ID Q6FHZ7
mRNA ID NM_001122
Length 437
RefSeq Status REVIEWED
MASVAVDPQPSVVTRVVNLPLVSSTYDLMSSAYLSTKDQYPYLKSVCEMAENGVKTITSVAMTSALPIIQKLEPQIAVANTYACKGLDRIEERLPILNQPSTQIVANAKGAVTGAKDAVTTTVTGAKDSVASTITGVMDKTKGAVTGSVEKTKSVVSGSINTVLGSRMMQLVSSGVENALTKSELLVEQYLPLTEEELEKEAKKVEGFDLVQKPSYYVRLGSLSTKLHSRAYQQALSRVKEAKQKSQQTISQLHSTVHLIEFARKNVYSANQKIQDAQDKLYLSWVEWKRSIGYDDTDESHCAEHIESRTLAIARNLTQQLQTTCHTLLSNIQGVPQNIQDQAKHMGVMAGDIYSVFRNAASFKEVSDSLLTSSKGQLQKMKESLDDVMDYLVNNTPLNWLVGPFYPQLTESQNAQDQGAEMDKSSQETQRSEHKTH

Gene Information

Entrez Gene ID
123
Gene Name
perilipin 2
Gene Symbol
PLIN2
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 IEA:Ensembl C cytosol
GO:0005811 IEA:Ensembl C lipid particle
GO:0005634 IEA:Ensembl C nucleus
GO:0005886 IEA:Ensembl C plasma membrane
GO:0019915 IEA:Ensembl P lipid storage
GO:0015909 IEA:Ensembl P long-chain fatty acid transport
GO:0042493 IEA:Ensembl P response to drug
GO:0014070 IEA:Ensembl P response to organic cyclic compound

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_116145 PPARA activates gene expression
REACT_19241 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)

Domain Information

InterPro Annotations

Accession Description
IPR004279 Perilipin

UniProt Annotations

Entry Information

Gene Name
perilipin 2
Protein Entry
PLIN2_HUMAN
UniProt ID
Q6FHZ7
Species
Human

Identical and Related Proteins

Unique RefSeq proteins for LMP001788 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
34577059 RefSeq NP_001113 437 perilipin-2

Identical Sequences to LMP001788 proteins

Reference Database Accession Length Protein Name
GI:34577059 GenBank AEN35552.1 437 Sequence 1480 from patent US 7998689
GI:34577059 GenBank AEN35553.1 437 Sequence 1481 from patent US 7998689
GI:34577059 GenBank AEN35554.1 437 Sequence 1482 from patent US 7998689
GI:34577059 GenBank AEU55602.1 437 Sequence 12 from patent US 8066971
GI:34577059 GenBank AEU55603.1 437 Sequence 14 from patent US 8066971
GI:34577059 GenBank AHD77478.1 437 Sequence 23607 from patent US 8586006

Related Sequences to LMP001788 proteins

Reference Database Accession Length Protein Name
GI:34577059 EMBL CAA65989.1 437 adipophilin, partial [Homo sapiens]
GI:34577059 EMBL CAC09025.1 437 unnamed protein product [Homo sapiens]
GI:34577059 GenBank AAE37398.1 437 Sequence 3 from patent US 5989820
GI:34577059 GenBank AIC53958.1 437 PLIN2, partial [synthetic construct]
GI:34577059 pat US 437 Sequence 1 from patent US 5739009
GI:34577059 RefSeq XP_004047889.1 437 PREDICTED: perilipin-2 [Gorilla gorilla gorilla]