LIPID MAPS

LMPD ID

LMP001781

Gene ID

15494

Species

Mus musculus (Mouse)

Gene Name

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3

Gene Symbol

Hsd3b3

Synonyms

9030618K22Rik; AI790201

Alternate Names

3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 3; 3-beta-HSD III; progesterone reductase; steroid delta-isomerase; delta-5-3-ketosteroid isomerase; 3 beta-hydroxysteroid dehydrogenase 3; 3-beta-hydroxy-5-ene steroid dehydrogenase; hydroxysteroid dehydrogenase-2, delta<5>-3-beta; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type III

Chromosome

3

Map Location

3 F2.2|3 42.86 cM

EC Number

1.1.1.145

3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 3 isoform 1
Refseq ID	NP_001155214
Protein GI	240120134
UniProt ID	P26150
mRNA ID	NM_001161742
Length	373
RefSeq Status	VALIDATED
MPGWSCLVTGAGGFLGQRIIQLLVQEKDLEEIRVLDKVFKPETREQFFNLGTSIKVTVLEGDILDTQYLRRACQGISVVIHTAAIIDVTGVIPRQTILDVNLKGTQNLLEACIQASVPAFIFSSSVDVAGPNSYKDIVLNGHEDEHRESTWSDPYPYSKKMAEKAVLAANGSMLKNGGTLQTCALRPMCIYGERSQFLSNTIIKALKNKFILRGGGKFSTANPVYVGNVAWAHILAARGLRNPKKSPNIQGEFYYISDDTPHQSYDDLNYTLSKEWGFCLNSRWYLPVPILYWLAFLLETVSFLLSPIYRYIPPFNRHLVTLTASTFTFSYKKAQRDLGYEPLVSWEEAKQKTSEWIGTLVEQHRETLDTKSQ

3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 3 isoform 1
Refseq ID	NP_001155217
Protein GI	240120140
UniProt ID	P26150
mRNA ID	NM_001161745
Length	373
RefSeq Status	VALIDATED
Protein sequence is identical to GI:240120134 (mRNA isoform)

3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 3 isoform 1
Refseq ID	NP_001155215
Protein GI	240120136
UniProt ID	P26150
mRNA ID	NM_001161743
Length	373
RefSeq Status	VALIDATED
Protein sequence is identical to GI:240120134 (mRNA isoform)

3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 3 isoform 1
Refseq ID	NP_001155216
Protein GI	240120138
UniProt ID	P26150
mRNA ID	NM_001161744
Length	373
RefSeq Status	VALIDATED
Protein sequence is identical to GI:240120134 (mRNA isoform)

Entrez Gene ID

15494

Gene Name

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3

Gene Symbol

Hsd3b3

Species

Mus musculus

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005783	IEA:UniProtKB-KW	C	endoplasmic reticulum
GO:0016021	IEA:UniProtKB-KW	C	integral component of membrane
GO:0005743	IDA:MGI	C	mitochondrial inner membrane
GO:0003854	IEA:UniProtKB-EC	F	3-beta-hydroxy-delta5-steroid dehydrogenase activity
GO:0004769	IEA:UniProtKB-EC	F	steroid delta-isomerase activity
GO:0006694	IEA:UniProtKB-UniPathway	P	steroid biosynthetic process

REACTOME Pathway Links

REACTOME Pathway ID	Description
5893451	Androgen biosynthesis
5893452	Glucocorticoid biosynthesis
5893446	Mineralocorticoid biosynthesis

InterPro Annotations

Accession	Description
IPR002225	3-beta hydroxysteroid dehydrogenase/isomerase
IPR016040	NAD(P)-binding domain

Entry Information

Gene Name

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3

Protein Entry

3BHS3_MOUSE

UniProt ID

P26150

Species

Mouse

Comments

Comment Type	Description
Catalytic Activity	A 3-beta-hydroxy-Delta(5)-steroid + NAD(+) = a 3-oxo-Delta(5)-steroid + NADH.
Catalytic Activity	A 3-oxo-Delta(5)-steroid = a 3-oxo-Delta(4)- steroid.
Function	3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids.
Pathway	Lipid metabolism; steroid biosynthesis.
Similarity	Belongs to the 3-beta-HSD family. {ECO:0000305}.
Subcellular Location	Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein.
Tissue Specificity	Liver and kidney. Greater expression in liver.

Unique RefSeq proteins for LMP001781 (as displayed in Record Overview)

Protein GI	Database	Accession	Length	Protein Name
240120134	RefSeq	NP_001155214	373	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 3 isoform 1

Identical Sequences to LMP001781 proteins

Reference	Database	Accession	Length	Protein Name
GI:240120134	GenBank	EDL38969.1	373	mCG140534, isoform CRA_a [Mus musculus]
GI:240120134	RefSeq	NP_001155215.1	373	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 3 isoform 1 [Mus musculus]
GI:240120134	RefSeq	NP_001155216.1	373	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 3 isoform 1 [Mus musculus]
GI:240120134	RefSeq	NP_001155217.1	373	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 3 isoform 1 [Mus musculus]
GI:240120134	RefSeq	XP_006501104.1	373	PREDICTED: 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 3 isoform X3 [Mus musculus]
GI:240120134	RefSeq	XP_006501105.1	373	PREDICTED: 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 3 isoform X4 [Mus musculus]

Related Sequences to LMP001781 proteins

Reference	Database	Accession	Length	Protein Name
GI:240120134	GenBank	EDL38970.1	390	mCG140534, isoform CRA_b, partial [Mus musculus]
GI:240120134	RefSeq	NP_694873.2	373	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 [Mus musculus]
GI:240120134	RefSeq	XP_006501101.1	373	PREDICTED: 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 isoform X1 [Mus musculus]
GI:240120134	RefSeq	XP_006501102.1	403	PREDICTED: 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 3 isoform X1 [Mus musculus]
GI:240120134	RefSeq	XP_006501103.1	376	PREDICTED: 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 3 isoform X2 [Mus musculus]
GI:240120134	SwissProt	P26149.4	373	RecName: Full=3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2; AltName: Full=3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II; Short=3-beta-HSD II; Includes: RecName: Full=3-beta-hydroxy-Delta(5)-steroid dehydrogenase; AltName: Full=3-beta-hydroxy-5-ene steroid dehydrogenase; AltName: Full=Progesterone reductase; Includes: RecName: Full=Steroid Delta-isomerase; AltName: Full=Delta-5-3-ketosteroid isomerase [Mus musculus]