Gene/Proteome Database (LMPD)
LMPD ID
LMP001758
Gene ID
Species
Mus musculus (Mouse)
Gene Name
beta-carotene oxygenase 1
Gene Symbol
Synonyms
Bcdo; Bcdo1; Bcmo1; CMO1; Cmoi; beta-CD; betaCMOOX
Chromosome
8
Map Location
8 E1|8
Summary
Vitamin A metabolism is important for vital processes such as vision, embryonic development, cell differentiation, and membrane and skin protection. The protein encoded by this gene is a key enzyme in beta-carotene metabolism to vitamin A. It catalyzes the oxidative cleavage of beta,beta-carotene into two retinal molecules. Two alternatively spliced variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]
Orthologs
Proteins
| beta,beta-carotene 15,15'-monooxygenase isoform 1 | |
|---|---|
| Refseq ID | NP_067461 |
| Protein GI | 11993946 |
| UniProt ID | Q9JJS6 |
| mRNA ID | NM_021486 |
| Length | 566 |
| RefSeq Status | REVIEWED |
| MEIIFGQNKKEQLEPVQAKVTGSIPAWLQGTLLRNGPGMHTVGESKYNHWFDGLALLHSFSIRDGEVFYRSKYLQSDTYIANIEANRIVVSEFGTMAYPDPCKNIFSKAFSYLSHTIPDFTDNCLINIMKCGEDFYATTETNYIRKIDPQTLETLEKVDYRKYVAVNLATSHPHYDEAGNVLNMGTSVVDKGRTKYVIFKIPATVPDSKKKGKSPVKHAEVFCSISSRSLLSPSYYHSFGVTENYVVFLEQPFKLDILKMATAYMRGVSWASCMSFDREDKTYIHIIDQRTRKPVPTKFYTDPMVVFHHVNAYEEDGCVLFDVIAYEDSSLYQLFYLANLNKDFEEKSRLTSVPTLRRFAVPLHVDKDAEVGSNLVKVSSTTATALKEKDGHVYCQPEVLYEGLELPRINYAYNGKPYRYIFAAEVQWSPVPTKILKYDILTKSSLKWSEESCWPAEPLFVPTPGAKDEDDGVILSAIVSTDPQKLPFLLILDAKSFTELARASVDADMHLDLHGLFIPDADWNAVKQTPAETQEVENSDHPTDPTAPELSHSENDFTAGHGGSSL | |
| beta,beta-carotene 15,15'-monooxygenase isoform 2 | |
|---|---|
| Refseq ID | NP_001156500 |
| Protein GI | 253314530 |
| UniProt ID | E9Q321 |
| mRNA ID | NM_001163028 |
| Length | 526 |
| RefSeq Status | REVIEWED |
| MEIIFGQNKKEQLEPVQAKVTGSIPAWLQGTLLRNGPGMHTVGESKYNHWFDGLALLHSFSIRDGEVFYRSKYLQSDTYIANIEANRIVVSEFGTMAYPDPCKNIFSKAFSYLSHTIPDFTDNCLINIMKCGEDFYATTETNYIRKIDPQTLETLEKVDYRKYVAVNLATSHPHYDEAGNVLNMGTSVVDKGRTKYVIFKIPATVPDSKKKGKSPVKHAEVFCSISSRSLLSPSYYHSFGVTENYVVFLEQPFKLDILKMATAYMRGVSWASCMSFDREDKTYIHIIDQRTRKPVPTKFYTDPMVVFHHVNAYEEDGCVLFDVIAYEDSSLYQLFYLANLNKDFEEKSRLTSVPTLRRFAVPLHVDKDAEVGSNLVKVSSTTATALKEKDGHVYCQPEVLYEGLELPRINYAYNGKPYRYIFAAEVQWSPVPTKILKYDILTKSSLKWSEESCWPAEPLFVPTPGAKDEDDVPCRPSRDCGVQGPHRKSHCQLSIACVPEISAFGRQTEDNQGSTVILRYTENLNY | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0003834 | ISS:MGI | F | beta-carotene 15,15'-monooxygenase activity |
| GO:0055114 | ISS:GOC | P | oxidation-reduction process |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR004294 | Carotenoid oxygenase |
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Caution | The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. |
| Similarity | Belongs to the carotenoid oxygenase family. |
Identical and Related Proteins
Unique RefSeq proteins for LMP001758 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 11993946 | RefSeq | NP_067461 | 566 | beta,beta-carotene 15,15'-monooxygenase isoform 1 |
| 253314530 | RefSeq | NP_001156500 | 526 | beta,beta-carotene 15,15'-monooxygenase isoform 2 |
Identical Sequences to LMP001758 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:11993946 | EMBL | CAB92531.2 | 566 | beta,beta-carotene 15,15'-dioxygenase [Mus musculus] |
| GI:11993946 | GenBank | AAM76677.1 | 566 | beta-carotene 15,15'-monooxygenase [Mus musculus] |
| GI:11993946 | GenBank | AAI25329.1 | 566 | Beta-carotene 15,15'-monooxygenase [Mus musculus] |
| GI:11993946 | GenBank | AAI25331.1 | 566 | Beta-carotene 15,15'-monooxygenase [Mus musculus] |
| GI:11993946 | GenBank | EDL11579.1 | 566 | beta-carotene 15,15'-monooxygenase [Mus musculus] |
| GI:11993946 | SwissProt | Q9JJS6.2 | 566 | RecName: Full=Beta,beta-carotene 15,15'-monooxygenase; AltName: Full=Beta-carotene dioxygenase 1; AltName: Full=Beta-carotene oxygenase 1 [Mus musculus] |
Related Sequences to LMP001758 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:11993946 | DBBJ | BAB60807.1 | 566 | beta-carotene 15,15'-dioxygenase [Rattus norvegicus] |
| GI:253314530 | EMBL | CAB92531.2 | 566 | beta,beta-carotene 15,15'-dioxygenase [Mus musculus] |
| GI:11993946 | GenBank | AAG15381.1 | 566 | beta, beta-carotene 15,15'-dioxygenase [Mus musculus] |
| GI:253314530 | GenBank | AAG33982.1 | 566 | beta-carotene 15,15'-dioxygenase [Mus musculus] |
| GI:253314530 | GenBank | AAI25331.1 | 566 | Beta-carotene 15,15'-monooxygenase [Mus musculus] |
| GI:253314530 | GenBank | EDL11579.1 | 566 | beta-carotene 15,15'-monooxygenase [Mus musculus] |
| GI:11993946 | GenBank | EDL92648.1 | 566 | beta-carotene 15,15'-monooxygenase [Rattus norvegicus] |
| GI:11993946 | GenBank | AIJ28580.1 | 570 | beta-carotene 15,15'-dioxygenase, partial [synthetic construct] |
| GI:11993946 | RefSeq | NP_446100.2 | 566 | beta,beta-carotene 15,15'-monooxygenase [Rattus norvegicus] |
| GI:253314530 | RefSeq | XP_005372561.1 | 526 | PREDICTED: LOW QUALITY PROTEIN: beta-carotene 15,15'-monooxygenase 1 [Microtus ochrogaster] |
| GI:253314530 | SwissProt | Q9JJS6.2 | 566 | RecName: Full=Beta,beta-carotene 15,15'-monooxygenase; AltName: Full=Beta-carotene dioxygenase 1; AltName: Full=Beta-carotene oxygenase 1 [Mus musculus] |
| GI:11993946 | SwissProt | Q91XT5.1 | 566 | RecName: Full=Beta,beta-carotene 15,15'-monooxygenase; AltName: Full=Beta-carotene dioxygenase 1; AltName: Full=Beta-carotene oxygenase 1 [Rattus norvegicus] |