Gene/Proteome Database (LMPD)

LMPD ID
LMP001743
Gene ID
17855
Species
Mus musculus (Mouse)
Gene Name
mevalonate kinase
Gene Symbol
Mvk
Synonyms
2310010A05Rik; AI256848; AI414037; MK
Alternate Names
mevalonate kinase
Chromosome
5
Map Location
5 F|5 55.99 cM
EC Number
2.7.1.36

Proteins

mevalonate kinase
Refseq ID NP_076045
Protein GI 12963731
UniProt ID Q9R008
mRNA ID NM_023556
Length 395
RefSeq Status PROVISIONAL
MLSEALLVSAPGKVILHGEHAVVHGKVALAAALNLRTFLLLRPQSNGKVSVNLPNIGIKQVWDVGMLQRLDTSFLEQGDVSVPTLEQLEKLKKMGDLPRDRAGNEGMALLAFLYLYLAICRKQRTLPSLDMVVWSELPPGAGLGSSAAYSVCLAAALLTACEEVSNPLKDGVSVSRWPEEDLKSINKWAFEGERVIHGNPSGVDNAVSTWGGALRFQQGTMSSLKSLPSLQILLTNTKVPRSTKALVAAVRSRLTKFPEIVAPLLTSIDAISLECERVLGEMVAAPVPEQYLVLEELIDMNQHHLNALGVGHNSLDQLCQVTAAHGLHSKLTGAGGGGCGITLLKPGLEQATVEAAKQALTSCGFDCWETSIGAPGVSTHSAAAVGDPVRQALGL

Gene Information

Entrez Gene ID
17855
Gene Name
mevalonate kinase
Gene Symbol
Mvk
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 IEA:Ensembl C cytosol
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0004496 IDA:MGI F mevalonate kinase activity
GO:0006695 IEA:UniProtKB-KW P cholesterol biosynthetic process
GO:0019287 IEA:UniProtKB-UniPathway P isopentenyl diphosphate biosynthetic process, mevalonate pathway
GO:0050728 IEA:Ensembl P negative regulation of inflammatory response

KEGG Pathway Links

KEGG Pathway ID Description
mmu04146 Peroxisome
mmu00900 Terpenoid backbone biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR006204 GHMP kinase N-terminal domain
IPR006203 GHMP kinase, ATP-binding, conserved site
IPR013750 GHMP kinase, C-terminal domain
IPR006205 Mevalonate kinase
IPR006206 Mevalonate/galactokinase
IPR020568 Ribosomal protein S5 domain 2-type fold
IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup

UniProt Annotations

Entry Information

Gene Name
mevalonate kinase
Protein Entry
KIME_MOUSE
UniProt ID
Q9R008
Species
Mouse

Comments

Comment Type Description
Catalytic Activity ATP + (R)-mevalonate = ADP + (R)-5- phosphomevalonate.
Enzyme Regulation Farnesyl- and geranyl-pyrophosphates are competitive inhibitors. {ECO:0000250}.
Function May be a regulatory site in cholesterol biosynthetic pathway.
Pathway Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.
Similarity Belongs to the GHMP kinase family. Mevalonate kinase subfamily. {ECO:0000305}.
Subcellular Location Cytoplasm {ECO:0000250}.
Subunit Homodimer. {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP001743 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
12963731 RefSeq NP_076045 395 mevalonate kinase

Identical Sequences to LMP001743 proteins

Reference Database Accession Length Protein Name
GI:12963731 GenBank AAF00700.1 395 mevalonate kinase [Mus musculus]
GI:12963731 GenBank AAH05606.1 395 Mevalonate kinase [Mus musculus]
GI:12963731 GenBank ADI53345.1 395 Sequence 3 from patent US 7422884
GI:12963731 GenBank AGD02018.1 395 Sequence 31 from patent US 8338155
GI:12963731 RefSeq XP_006530248.1 395 PREDICTED: mevalonate kinase isoform X3 [Mus musculus]
GI:12963731 SwissProt Q9R008.1 395 RecName: Full=Mevalonate kinase; Short=MK [Mus musculus]

Related Sequences to LMP001743 proteins

Reference Database Accession Length Protein Name
GI:12963731 DBBJ BAE28997.1 407 unnamed protein product [Mus musculus]
GI:12963731 GenBank EDM13937.1 395 mevalonate kinase, isoform CRA_a [Rattus norvegicus]
GI:12963731 GenBank ADI53346.1 395 Sequence 4 from patent US 7422884
GI:12963731 PDB 1KVK 395 Chain A, The Structure Of Binary Complex Between A Mammalian Mevalonate Kinase And Atp: Insights Into The Reaction Mechanism And Human Inherited Disease
GI:12963731 RefSeq XP_006530246.1 407 PREDICTED: mevalonate kinase isoform X1 [Mus musculus]
GI:12963731 RefSeq XP_006530247.1 407 PREDICTED: mevalonate kinase isoform X2 [Mus musculus]