Gene/Proteome Database (LMPD)

LMPD ID
LMP001715
Gene ID
231871
Species
Mus musculus (Mouse)
Gene Name
diacylglycerol lipase, beta
Gene Symbol
Daglb
Synonyms
E330036I19Rik
Alternate Names
sn1-specific diacylglycerol lipase beta; DGL-beta
Chromosome
5
Map Location
5 G2|5
EC Number
3.1.1.-

Proteins

sn1-specific diacylglycerol lipase beta
Refseq ID NP_659164
Protein GI 31559956
UniProt ID Q91WC9
mRNA ID NM_144915
Length 669
RefSeq Status VALIDATED
MPGMVLFGRRWSLASDDLVFPGSFELFLRVLWWIVSLTLYLTHRRRLDCPGGVLLSTYLIVLLVLLAVIICTVLAIVCVSMRGTICNPGPRKSMSKLLYIRLALFLPEMVWASLGAAWVAKGIQCDRTVVIGIIATVIVSWIVIAATMVTIIFVFDPLGGKMAPYPPCIPEHLDSNSSNRLLTGLKTAAKSVWETRVQFCCCCVGQDDNTRVAFSSTADLFSTYFSDTDLVPSDIAAGFTLLHQQQDNISHSREPPEVVTHTPGQPQETELDAEVENCHHYMPFAAAAYGWPLYIYRNPFTGLCRIGGDCCRARDIEYDAVEGDQHNCHFASILKTTGLQYRDFIHISFHDKVYELPFIVVLDHRKESVVVAVRGTMSLQDVLTDLSAESETLELGIELQDCVAHKGIAQAARYIHRRLVNDGILSQAFSVAPEYQLVLVGHSLGAGAAALLAIMLRGAYPQVRAYAFSPPRGLLSKSLYEYSKDFVVSLILGMDVIPRLSVTNMEDLKRRILRVIANCNKPKYKILLHGCWYGLFGGSPDNFPTELDEGTQGALTQPLLGEQTLLTRYSPGYCSSDSPLDSPTKYPTLYPPGRIIHLEEEGGSGRFGCCSAAQYRARWAHEAEFSKILIGPKMLIDHMPDVMIRALDRVLADRTACVSCPGQGGSSVP

Gene Information

Entrez Gene ID
231871
Gene Name
diacylglycerol lipase, beta
Gene Symbol
Daglb
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005765 IEA:Ensembl C lysosomal membrane
GO:0005886 IEA:UniProtKB-KW C plasma membrane
GO:0016787 IEA:UniProtKB-KW F hydrolase activity
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0019369 IMP:MGI P arachidonic acid metabolic process
GO:0016042 IEA:UniProtKB-KW P lipid catabolic process
GO:0007405 IMP:MGI P neuroblast proliferation
GO:0022008 IMP:MGI P neurogenesis
GO:0042136 IMP:MGI P neurotransmitter biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
ko04723 Retrograde endocannabinoid signaling
mmu04723 Retrograde endocannabinoid signaling

REACTOME Pathway Links

REACTOME Pathway ID Description
5893767 Arachidonate production from DAG
5893154 Platelet activation, signaling and aggregation

Domain Information

InterPro Annotations

Accession Description
IPR029058 Alpha/Beta hydrolase fold
IPR002921 Fungal lipase-like domain

UniProt Annotations

Entry Information

Gene Name
diacylglycerol lipase, beta
Protein Entry
DGLB_MOUSE
UniProt ID
Q91WC9
Species
Mouse

Comments

Comment Type Description
Cofactor Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250};
Function Catalyzes the hydrolysis of diacylglycerol (DAG) to 2- arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses (By similarity). {ECO:0000250}.
Sequence Caution Sequence=BAC39734.1; Type=Frameshift; Positions=102; Evidence={ECO:0000305};
Similarity Belongs to the AB hydrolase superfamily. Lipase family. {ECO:0000305}.
Subcellular Location Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Tissue Specificity In embryonic brains, it is present in axonal tracts, while in adults it localizes to dendritic fields, correlating with the developmental change in requirement for 2-AG synthesis from the pre- to the postsynaptic compartment (at protein level). {ECO:0000269|PubMed:14610053}.

Identical and Related Proteins

Unique RefSeq proteins for LMP001715 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
31559956 RefSeq NP_659164 669 sn1-specific diacylglycerol lipase beta

Identical Sequences to LMP001715 proteins

Reference Database Accession Length Protein Name
GI:31559956 DBBJ BAC40033.1 669 unnamed protein product [Mus musculus]
GI:31559956 DBBJ BAE22951.1 669 unnamed protein product [Mus musculus]
GI:31559956 GenBank AAH16105.2 669 Diacylglycerol lipase, beta [Mus musculus]
GI:31559956 SwissProt Q91WC9.2 669 RecName: Full=Sn1-specific diacylglycerol lipase beta; Short=DGL-beta [Mus musculus]

Related Sequences to LMP001715 proteins

Reference Database Accession Length Protein Name
GI:31559956 GenBank EDL89667.1 668 similar to KCCR13L (predicted) [Rattus norvegicus]
GI:31559956 RefSeq NP_001100590.1 668 sn1-specific diacylglycerol lipase beta [Rattus norvegicus]
GI:31559956 RefSeq XP_005080082.1 718 PREDICTED: sn1-specific diacylglycerol lipase beta [Mesocricetus auratus]
GI:31559956 RefSeq XP_007615067.1 671 PREDICTED: sn1-specific diacylglycerol lipase beta isoform X1 [Cricetulus griseus]
GI:31559956 RefSeq XP_008767183.1 669 PREDICTED: sn1-specific diacylglycerol lipase beta isoform X1 [Rattus norvegicus]
GI:31559956 SwissProt P0C1S9.1 668 RecName: Full=Sn1-specific diacylglycerol lipase beta; Short=DGL-beta [Rattus norvegicus]