Gene/Proteome Database (LMPD)

LMPD ID
LMP001710
Gene ID
139189
Species
Homo sapiens (Human)
Gene Name
diacylglycerol kinase, kappa
Gene Symbol
DGKK
Synonyms
-
Alternate Names
diacylglycerol kinase kappa; DGK-kappa; DAG kinase kappa; diglyceride kinase kappa; 142 kDa diacylglycerol kinase
Chromosome
X
Map Location
Xp11.22
EC Number
2.7.1.107
Summary
The protein encoded by this gene is an enzyme that phosphorylates diacylglycerol, converting it to phosphatidic acid. The encoded protein is a membrane protein and is inhibited by hydrogen peroxide. Variations in this gene have been associated with hypospadias. [provided by RefSeq, Mar 2011]
Orthologs
View orthologs and multiple alignments for DGKK

Proteins

diacylglycerol kinase kappa
Refseq ID NP_001013764
Protein GI 62000702
UniProt ID Q5KSL6
mRNA ID NM_001013742
Length 1271
RefSeq Status REVIEWED
MDRGAAAAQGTAPPQDGEQPAESPEPPPPWPPPPPPPAPPPAPPLLSEASPEPIPEPCPELAPGPCPEATSESATELYTEPTPEPATEPASEPAPEPATEPAPEPATEPAPEPAPEPATESAPEPTPEPALESVPEPAPELTPEVAPELAPEPTPEPVTELAPEFCPEAAPEFRPSPAPCLLQCPVDTRERGLKTSPSPSPSPSPRTPMSWSRIKKILKEGPMLKNCNSFKRWKLRYFLVQGQKLYFAHHPAFAHFETIDLSQATVAESSCRNLCHSFCVITPQRKITLAAPNRKDMEEWINIIKTIQQGEIYKIPAAENNPFLVGMHCWYSSYSHRTQHCNVCRESIPALSRDAIICEVCKVKSHRLCALRASKDCKWNTLSITDDLLLPADEVNMPHQWVEGNMPVSSQCAVCHESCGSYQRLQDFRCLWCNSTVHDDCRRRFSKECCFRSHRSSVIPPTALSDPKGDGQLVVSSDFWNLDWSSACSCPLLIFINSKSGDHQGIVFLRKFKQYLNPSQVFDLLKGGPEAGLSMFKNFARFRILVCGGDGSVSWVLSLIDAFGLHEKCQLAVIPLGTGNDLARVLGWGAFWNKSKSPLDILNRVEQASVRILDRWSVMIRETPRQTPLLKGQVEMDVPRFEAAAIQHLESAATELNKILKAKYPTEMIIATRFLCSAVEDFVVDIVKAWGQIKQNNTAIVSVILKSDLMYDRLSVLIDVLAEEAAATSAEKSATEYADSSKADRKPFIPQIDHIAKCKLELATKAQSLQKSLKLIIFQVEQALDEESRQTISVKNFSSTFFLEDDPEDINQTSPRRRSRRGTLSSISSLKSEDLDNLNLDHLHFTPESIRFKEKCVMNNYFGIGLDAKISLDFNTRRDEHPGQYNSRLKNKMWYGLLGTKELLQRSYRKLEERVHLECDGETISLPNLQGIVVLNITSYAGGINFWGSNTATTEYEAPAIDDGKLEVVAIFGSVQMAMSRIINLHHHRIAQCHEVMITIDGEEGIPVQVDGEAWIQRPGLIKIRYKNAAQMLTRDRDFENSMKMWEYKHTEIQAAPQPQLDFQDSQESLSDEEYAQMQHLARLAENLISKLNDLSKIHQHVSVLMGSVNASANILNDIFYGQDSGNEMGAASCIPIETLSRNDAVDVTFSLKGLYDDTTAFLDEKLLRSAEDETALQSALDAMNKEFKKLSEIDWMNPIFVPEEKSSDTDSRSLRLKIKFPKLGKKKVEEERKPKSGQSVQSFIGNLWHRRHREDEAEGDDPLTPSRSQL

Gene Information

Entrez Gene ID
139189
Gene Name
diacylglycerol kinase, kappa
Gene Symbol
DGKK
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0005886 IDA:HGNC C plasma membrane
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0003951 IEA:InterPro F NAD+ kinase activity
GO:0004143 IDA:HGNC F diacylglycerol kinase activity
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0007596 TAS:Reactome P blood coagulation
GO:0046339 IDA:HGNC P diacylglycerol metabolic process
GO:0035556 IDA:HGNC P intracellular signal transduction
GO:0030168 TAS:Reactome P platelet activation
GO:0007205 IEA:InterPro P protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0006979 IDA:HGNC P response to oxidative stress

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_2202 Effects of PIP2 hydrolysis
REACT_19184 GPCR downstream signaling
REACT_604 Hemostasis
REACT_798 Platelet activation, signaling and aggregation

Domain Information

InterPro Annotations

Accession Description
IPR016064 ATP-NAD kinase-like domain
IPR000756 Diacylglycerol kinase, accessory domain
IPR001206 Diacylglycerol kinase, catalytic domain
IPR001849 Pleckstrin homology domain
IPR011993 Pleckstrin homology-like domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain

UniProt Annotations

Entry Information

Gene Name
diacylglycerol kinase, kappa
Protein Entry
DGKK_HUMAN
UniProt ID
Q5KSL6
Species
Human

Comments

Comment Type Description
Catalytic Activity ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2- diacyl-sn-glycerol 3-phosphate.
Enzyme Regulation Inhibited in response to H(2)O(2).
Function Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA).
Ptm Phosphorylated at Tyr-78 by some member of the SRC family in response to H(2)O(2).
Similarity Belongs to the eukaryotic diacylglycerol kinase family.
Similarity Contains 1 DAGKc domain. {ECO
Similarity Contains 1 PH domain. {ECO
Similarity Contains 2 phorbol-ester/DAG-type zinc fingers.
Subcellular Location Cytoplasm . Membrane ; Peripheral membrane protein .
Subunit Does not form homooligomers.
Tissue Specificity Expressed in testis, and to a lesser extent in placenta.

Identical and Related Proteins

Unique RefSeq proteins for LMP001710 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
62000702 RefSeq NP_001013764 1271 diacylglycerol kinase kappa

Identical Sequences to LMP001710 proteins

Reference Database Accession Length Protein Name
GI:62000702 DBBJ BAD86792.1 1271 diacylglycerol kinase kappa [Homo sapiens]
GI:62000702 GenBank AAI37320.1 1271 Diacylglycerol kinase, kappa [Homo sapiens]
GI:62000702 GenBank AAI37321.1 1271 Diacylglycerol kinase, kappa [Homo sapiens]
GI:62000702 GenBank AIC62877.1 1271 DGKK, partial [synthetic construct]
GI:62000702 SwissProt Q5KSL6.1 1271 RecName: Full=Diacylglycerol kinase kappa; Short=DAG kinase kappa; AltName: Full=142 kDa diacylglycerol kinase; AltName: Full=Diglyceride kinase kappa; Short=DGK-kappa [Homo sapiens]

Related Sequences to LMP001710 proteins

Reference Database Accession Length Protein Name
GI:62000702 RefSeq XP_001083870.1 1265 PREDICTED: diacylglycerol kinase kappa [Macaca mulatta]
GI:62000702 RefSeq XP_002831694.1 1257 PREDICTED: diacylglycerol kinase kappa [Pongo abelii]
GI:62000702 RefSeq XP_003806000.1 1275 PREDICTED: LOW QUALITY PROTEIN: diacylglycerol kinase kappa [Pan paniscus]
GI:62000702 RefSeq XP_004064213.1 1243 PREDICTED: diacylglycerol kinase kappa [Gorilla gorilla gorilla]
GI:62000702 RefSeq XP_005593642.1 1265 PREDICTED: diacylglycerol kinase kappa isoform X1 [Macaca fascicularis]
GI:62000702 RefSeq XP_009195877.1 1281 PREDICTED: diacylglycerol kinase kappa [Papio anubis]