Gene/Proteome Database (LMPD)

LMPD ID
LMP001681
Gene ID
320150
Species
Mus musculus (Mouse)
Gene Name
zinc finger, DHHC domain containing 17
Gene Symbol
Zdhhc17
Synonyms
A230053P19Rik; BB187739; D130071N24Rik; Hip14
Alternate Names
palmitoyltransferase ZDHHC17; DHHC-17; huntingtin interacting protein 14; huntingtin-interacting protein 14; zinc finger DHHC domain-containing protein 17
Chromosome
10
Map Location
10 D1|10
EC Number
2.3.1.225

Proteins

palmitoyltransferase ZDHHC17
Refseq ID NP_766142
Protein GI 283837767
UniProt ID Q80TN5
mRNA ID NM_172554
Length 632
RefSeq Status VALIDATED
MQREEGFNTKMADGPDEYETETGCVPLLHPEEIKPQSHYNHGYGEPLGRKTHIDDYSTWDIVKATQYGIYERCRELVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDLNSTPLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMDQNGMTPLMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLAGNTTVISLLLEAGGNVDAQNVKGESALDLAKQRKNVWMINHLQEARQAKGYDNPSFLRKLKADKEFRQKVMLGTPFLVIWLVGFIADLDIDSWLIKGLMYGGVWATVQFLSKSFFDHSMHSALPLGIYLATKFWMYVTWFFWFWNDLNFLFIHLPFLANSVALFYNFGKSWKSDPGIIKATEEQKKKTIVELAETGSLDLSIFCSTCLIRKPVRSKHCGVCNRCIAKFDHHCPWVGNCVGAGNHRYFMGYLFFLLFMICWMIYGCVSYWGLHCETTYTKDGFWTYITQIATCSPWMFWMFLNSVFHFLWVAVLLMCQLYQITCLGITTNERMNARRYKHFKVTTTSIESPFNHGCVRNIIDFFEFRCCGLFRPVIVDWTRQYTIEYDQISGSGYQLV

Gene Information

Entrez Gene ID
320150
Gene Name
zinc finger, DHHC domain containing 17
Gene Symbol
Zdhhc17
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0000139 ISS:UniProtKB C Golgi membrane
GO:0030660 ISS:UniProtKB C Golgi-associated vesicle membrane
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0015095 ISS:UniProtKB F magnesium ion transmembrane transporter activity
GO:0016409 IDA:MGI F palmitoyltransferase activity
GO:0019706 ISS:UniProtKB F protein-cysteine S-palmitoyltransferase activity
GO:0004871 IEA:Ensembl F signal transducer activity
GO:0008270 IEA:InterPro F zinc ion binding
GO:0042953 IEA:Ensembl P lipoprotein transport
GO:0043123 IEA:Ensembl P positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0018345 IDA:MGI P protein palmitoylation

Domain Information

InterPro Annotations

Accession Description
IPR002110 Ankyrin repeat
IPR020683 Ankyrin repeat-containing domain
IPR001594 Zinc finger, DHHC-type, palmitoyltransferase

UniProt Annotations

Entry Information

Gene Name
zinc finger, DHHC domain containing 17
Protein Entry
ZDH17_MOUSE
UniProt ID
Q80TN5
Species
Mouse

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q80TN5-1; Sequence=Displayed; Name=2; IsoId=Q80TN5-2; Sequence=VSP_010026, VSP_010027;
Catalytic Activity Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.
Domain The DHHC domain is required for palmitoyltransferase activity. {ECO:0000250}.
Function Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HD. Palmitoylates MPP1 in erythrocytes. May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane. Has transforming activity. Mediates Mg(2+) transport. {ECO:0000269|PubMed:15489887, ECO:0000269|PubMed:15603741}.
Induction Up-regulated by low extracellular Mg(2+). {ECO:0000269|PubMed:18794299}.
Ptm Autopalmitoylated. Autopalmitoylation has a regulatory role in ZDHHC17-mediated Mg(2+) transport (By similarity). {ECO:0000250}.
Sequence Caution Sequence=AAH58772.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAC30090.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC30097.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC32912.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC65688.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Similarity Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily. {ECO:0000305}.
Similarity Contains 1 DHHC-type zinc finger. {ECO:0000255|PROSITE-ProRule:PRU00067}.
Similarity Contains 5 ANK repeats. {ECO:0000255|PROSITE- ProRule:PRU00023}.
Subcellular Location Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasmic vesicle membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Localized predominantly in the perinuclear regions of neurons from the cortex, striatum and hippocampus. Colocalized with HD in the medium spiny neurons of the striatum and the spiny neurons that project into the globus pallidus. {ECO:0000269|PubMed:12393793}.
Subunit Interacts (via ANK repeats) with HD. {ECO:0000250}.
Tissue Specificity Expressed in liver, testis, kidney, heart, pancreas and brain. Highest expression was seen in the brain. {ECO:0000269|PubMed:12393793}.

Identical and Related Proteins

Unique RefSeq proteins for LMP001681 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
283837767 RefSeq NP_766142 632 palmitoyltransferase ZDHHC17

Identical Sequences to LMP001681 proteins

Reference Database Accession Length Protein Name
GI:283837767 SwissProt Q80TN5.2 632 RecName: Full=Palmitoyltransferase ZDHHC17; AltName: Full=Huntingtin-interacting protein 14; AltName: Full=Zinc finger DHHC domain-containing protein 17; Short=DHHC-17 [Mus musculus]

Related Sequences to LMP001681 proteins

Reference Database Accession Length Protein Name
GI:283837767 DBBJ BAA76790.1 667 KIAA0946 protein, partial [Homo sapiens]
GI:283837767 GenBank EDM16743.1 632 rCG48691, isoform CRA_b [Rattus norvegicus]
GI:283837767 GenBank JAA18769.1 632 zinc finger, DHHC-type containing 17 [Pan troglodytes]
GI:283837767 RefSeq XP_005068117.1 632 PREDICTED: palmitoyltransferase ZDHHC17 [Mesocricetus auratus]
GI:283837767 RefSeq XP_005358134.1 632 PREDICTED: palmitoyltransferase ZDHHC17 [Microtus ochrogaster]
GI:283837767 RefSeq XP_006142915.1 632 PREDICTED: palmitoyltransferase ZDHHC17 [Tupaia chinensis]